Patents by Inventor Masuo Murakami
Masuo Murakami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4058665Abstract: 3,15-Dilower alkyl prostaglandin E.sub.2 derivatives and 3,15-dilower alkyl prostaglandin D.sub.2 derivatives are disclosed. These compounds have antigastric ulcer activity without undesirable side effects to intestinal organs.Type: GrantFiled: November 6, 1975Date of Patent: November 15, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Noriyoshi Inukai, Masuo Murakami, Hidenori Iwamoto, Isao Yanagisawa, Toshinari Tamura, Yoshio Ishii, Tetsuya Shizaoki, Kenichi Tomioka, Tokuichi Takagi
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Patent number: 4055589Abstract: A 20-alkoxy-16-alkyl-prostadienoic acid derivative shown by the formula ##STR1## wherein A represents ##STR2## R and R.sup.5, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group,And the pharmacologically acceptable nontoxic salts thereof.The compounds have excellent effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.alpha..Type: GrantFiled: December 15, 1975Date of Patent: October 25, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Noriyoshi Inukai, Masuo Murakami, Hidenori Iwamoto, Isao Yanagisawa, Toshinari Tamura, Yoshio Ishii, Kenichi Tomioka, Tetsuya Shiozaki, deceased
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Patent number: 4051126Abstract: An improved process of preparing a 6-alkoxy-substituted penicillin or penicillin sulfoxide is disclosed. This process comprises adding a halogenating agent to penicillin or penicillin sulfoxide while cooling, and then adding an alkali metal alcoholate to the hydrogenation product in the presence of an alcohol corresponding to the alcoholate.Type: GrantFiled: July 13, 1976Date of Patent: September 27, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Ichiro Isaka, Teruya Kashiwagi
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Patent number: 4045482Abstract: Novel indene derivatives represented by the general formula ##STR1## wherein R represents lower alkyl, phenylloweralkyl or lower cycloalkyl, and acid addition salts thereof useful as .beta.-receptor antagonists.Type: GrantFiled: April 14, 1975Date of Patent: August 30, 1977Assignee: Yamanouchi Pharmaceutical Co. Ltd.Inventors: Masuo Murakami, Kiyoshi Murase, Kunihiro Niigata, Shiro Tachikawa, Toichi Takenaka
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Patent number: 4041032Abstract: Pyrazine derivatives by the formula ##STR1## are disclosed. In the above formula, R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, a halogen atom, a hydroxy group, a lower alkoxy group, a phenyl lower alkoxy group, a phenoxy group, a mercapto group, a lower alkylthio group, a phenyl lower alkylthio group, a phenylthio group, an amino group, a substituted amino group, a lower alkyl group, a carbamoyl group or a sulfamoyl group; R.sup.3 represents a lower alkoxy group; R.sup.4, R.sup.5, and R.sup.6, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl lower alkyl group, or a phenyl group; and A represents a lower alkylene group; said R.sup.4 and A, said R.sup.5 and A, said R.sup.4 and R.sup.5, or said R.sup.5 and R.sup.Type: GrantFiled: December 19, 1974Date of Patent: August 9, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Kozo Takahashi, Yasuhumi Hirata, Mutsuo Takashima, Masaaki Takeda, Hiroyoshi Ino, Sumio Iwanami
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Patent number: 4036954Abstract: There is provided a process of preparing a prostaglandin E group-containing formulation by adding to a prostaglandin E group at least one additive selected from the group consisting of a thiol compound, a water soluble high molecular weight compound and a water-soluble salt of deoxycholic acid and then subjecting the mixture to lyophilization.Type: GrantFiled: October 21, 1974Date of Patent: July 19, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Shigemi Kawahara, Hiroitsu Kawata, Kiyoshi Okazaki, Jun Sekino, Hidemi Shimizu
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Patent number: 4036834Abstract: Novel 7-(.alpha.-hydroxy-substituted pyridylcarboxamido-.alpha.-phenylacetamido)-3-substituted thiomethyl-.DELTA..sup.3 -cephem-4-carboxylic acid derivatives are disclosed. The compounds of this invention have high water solubility and show excellent antibacterial activities against various strains of Pseudomonas and Proteus.Type: GrantFiled: October 8, 1975Date of Patent: July 19, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Masaru Iwanami, Ichiro Isaka, Yoshinobu Nagano, Masaharu Fujimoto, Tetsuya Maeda
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Patent number: 4026927Abstract: Novel prostaglandin derivatives are provided having the formula: ##STR1## wherein A represents ##STR2## one of R.sub.3 and R.sub.4 represents a hydrogen atom and the other of them represents a lower alkyl group; one of R.sub.5 and R.sub.6 represents a hydrogen atom and the other of them represents a hydroxyl group; and one of R.sub.7 and R.sub.8 represents a hydrogen atom and the other of them represents a lower alkyl group.The compounds of this invention have excellent effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.sub..alpha..Type: GrantFiled: September 23, 1974Date of Patent: May 31, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Noriyoshi Inukai, Hidenori Iwamoto, Toshinari Tamura, Isao Yanagisawa, Osamu Hasegawa, Yoshio Ishii, Hideya Matsuda, Tetsuya Shiozaki, Kenichi Tomioka
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Patent number: 4021434Abstract: Novel 1-substituted-1, 4-dihydropyridine derivatives, particularly diethyl 1-ethoxymethyl-4-(3-nitrophenyl)-2, 6-dimethyl-1, 4-dihydropyridine-3,5-dicarboxylate are provided. The novel derivatives have cerebral vascular dilator activity with low toxicity.Type: GrantFiled: August 21, 1975Date of Patent: May 3, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Kozo Takahashi, Teruaki Ozasa, Kazuharu Tamazawa, Ryutaro Kawai, Toichi Takenaka, Norio Sato
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Patent number: 4013773Abstract: A single phase solid composition wherein one part of a non-aqueous liquid and 0.5-6 parts of calcium lactate hydrate are mixed and heated. The product according to this invention is very stable and can be formed into various kinds of moldings by a simple operation so that it may be applied to many uses.Type: GrantFiled: February 4, 1975Date of Patent: March 22, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Hiroitsu Kawada, Tadayoshi Ohmura, Hiroshi Sugiura
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Patent number: 3994974Abstract: Novel .alpha.-aminomethylbenzyl alcohol derivatives, particularly .alpha.-aminoethyl-3-substituted amino-4-hydroxybenzyl alcohol derivatives. The compounds of this invention are useful as bronchodilating agents.Type: GrantFiled: May 7, 1974Date of Patent: November 30, 1976Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Kozo Takahashi, Toshiyasu Mase, Kiyoshi Murase, Hisashi Ida
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Patent number: 3991111Abstract: N-alkenyltetracycline derivatives, for example, N-(1-methyl-2-.alpha.-naphthylethenyl)tetracycline represented by the formula ##SPC1##The compounds have excellent antibacterial action as compared with tetracycline.Type: GrantFiled: May 6, 1975Date of Patent: November 9, 1976Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Masaru Iwanami, Tadao Shibanuma, Masaharu Fujimoto, Norio Sato, Ryutaro Kawai, Kuniichiro Yano
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Patent number: 3985758Abstract: There are provided novel 1,4-dihydropyridine derivatives, particularly 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-.beta.-(N-benzyl-N-methylamino)ethyl ester and 5-methyl ester. The 1,4-dihydropyridine derivatives are characterized by cerebral vascular dilator activity.Type: GrantFiled: June 6, 1975Date of Patent: October 12, 1976Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Kozo Takahashi, Masaru Iwanami, Masaharu Fujimoto, Tadao Shibanuma, Ryutaro Kawai, Toichi Takenaka
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Patent number: 3953437Abstract: A process of preparing a .DELTA..sup.3 -cephalosporanic acid ester derivative which comrises reacting a cephalosporanic acid sulfoxide ester derivative with thionyl halide or a phosphorous halide.The compounds prepared by the process of this invention are useful as intermediate compounds for preparing cephalosporin antibiotics and the compounds themselves are also potential antibacterials.Type: GrantFiled: March 8, 1974Date of Patent: April 27, 1976Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Kozo Takahashi, Teruaki Ozasa
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Patent number: 3953428Abstract: The ampicillin derivatives represented by the general formula ##SPC1##Wherein R represents ##SPC2##Wherein R' represents a hydrogen atom, a methyl group, or an ethyl group and A and B each represents a hydrogen atom, a hydroxyl group, a methyl group, a methoxy group, a nitro group, or a halogen atom and further said B may combine with A on the carbon atom at the position to form ##SPC3##Group (where in Z represents --CH=N-- or --CH=CH-- and an R.sup.2 represents a hydrogen atom, a hydroxyl group, a phenyl group, a methyl group, an ethyl group, a methoxy group, an ethoxyl group, a methylthio group, a trifluoromethyl group, a halogen atom, a nitro group, an acetyl group, an acetamido group, a ethoxycarbonyloxy group, or a methylsulfonyl group and further R.sub.2 and ##SPC4##May form a thiazole, isothiazolo, pyrrolo, furo, or benzo fused ring which may be substituted by an oxo group, a methyl group, or an acetyl group) and the dotted line means an arbitrary double bond, ##SPC5##Wherein R.sup.3 and R.sup.Type: GrantFiled: May 1, 1973Date of Patent: April 27, 1976Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Ichiro Isaka, Akio Koda, Norio Kawahara, Teruya Ashiwagi, Yukiyasu Murakami, Kuniichiro Yano, Kohzi Nakano, Isao Souzo
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Patent number: 3951962Abstract: N-alkenyltetracycline derivatives, for example, N-[1-methyl-2(2-thienyl)-1-butenyl]tetracycline represented by the formula ##SPC1##The compounds have excellent antibacterial action as compared with tetracycline.Type: GrantFiled: March 19, 1975Date of Patent: April 20, 1976Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Masaru Iwanami, Tadao Shibanuma, Masaharu Fujimoto, Norio Sato, Ryutaro Kawai, Kuniichiro Yano
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Patent number: 3951954Abstract: The oxofuryl ester derivatives of 6-(.alpha.-amino-phenylacetamido)penicillanic acid, 7-(.alpha.-aminophenylacetamido)-cephalosporanic acid, or 7-(.alpha. -aminophenylacetamide)desacetoxycephalosporanic acid represented by the general formula ##SPC1##Wherein A represents ##SPC2##Wherein R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, said R.sup.1 and R.sup.2 may form together a 1,3-butadienylene group, R.sup.3 represents a hydrogen atom or an acetoxy group, andMeans a single bond or a double bond, and acid addition salts of them. When those compounds are orally administered, they are readily absorbed by the intestines and show antibacterial activity by splitting their ester bonds. The rate of absorption of the compounds by the intestines are higher and the toxic property of them is less than those of known compounds similar to the above compounds.Type: GrantFiled: February 18, 1975Date of Patent: April 20, 1976Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Ichiro Isaka, Teruya Kashiwagi, Hidefumi Matsui, Kohzi Nakano, Kozo Takahashi, Hiroshi Horiguchi, Akio Koda
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Patent number: 3939150Abstract: The penicillin derivatives represented by the formula ##SPC1##Wherein ring A represents a 5- or 6-membered single or fused ring which may contain one or more nitrogen atoms, an oxygen atom, or a sulfur atom; R.sup.1, R.sup.2, and R.sup.3, which may be the same or different, each represents a hydrogen atom, a hydroxy group, a lower alkyl group, a nitro group, a halogen atom, or an oxo group; and B represents a p-hydroxyphenyl group or a 1,4-cyclohexadien -1-yl group, and their nontoxic pharmaceutically acceptable salts.The compounds are antibiotics having excellent antibacterial activity in particular with respect to the Pseudomonas genus.Type: GrantFiled: October 15, 1974Date of Patent: February 17, 1976Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Ichiro Isaka, Khozi Nakano, Isao Souzu, Akio Koda, Teruaki Ozasa, Teruya Kashiwagi, Yukiyasu Murakami
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Patent number: 3935198Abstract: A process for the preparation of cephalosporanic acid derivatives represented by the formula ##SPC1##Wherein R.sub.1 and R.sub.2, which may be the same or different, each represents a univalent group other than a hydrogen atom, said R.sub.1 and R.sub.2 may be combined to form a divalent group and A represents a divalent group represented by the formulae ##SPC2##Wherein R.sub.3 represents a hydrogen atom or a group which does not contribute to the reaction, which comprises heating a penicillin sulfoxide derivative represented by the formula ##SPC3##Wherein R.sub.1, R.sub.2 and R.sub.3 are as defined above.The cephalosporanic acid derivatives prepared by the process of this invention are useful as a starting material for the preparation of antibacterials.Type: GrantFiled: December 19, 1973Date of Patent: January 27, 1976Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Kozo Takahashi, Ichiro Isaka, Teruaki Ozasa, Teruya Kashiwagi