Patents by Inventor Matías Ávila Zaragoza

Matías Ávila Zaragoza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of 5?-methylthioadenosine (MTA) in the prevention and/or treatment of autoimmune diseases and/or transplant rejection
    Patent number: 7820637
    Abstract: 5?-methylthioadenosine (MTA), its pharmaceutically acceptable salts and/or prodrugs may be used in the prevention and/or treatment of autoimmune diseases, such as, for example, Multiple Sclerosis (MS), as well as in the prevention and/or treatment of transplant rejection.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: October 26, 2010
    Assignee: Proyecto de Biomedicina Cima, S.L.
    Inventors: Pablo Villoslada Díaz, Matías Ávila Zaragoza, Beatriz Moreno Bruna, Fernando Corrales Izquierdo, Carmen Berasain Lasarte, Elena Ruiz García-Trevijano
  • MOLECULAR MARKERS OF HEPATOCELLULAR CARCINOMA AND THEIR APPLICATIONS
    Publication number: 20090181379
    Abstract: By means of a proteomic approach, the markers of hepatocellular carcinoma (HCC) in the liver of a knockout mouse (MAT1A?/?) have been identified for the MAT1A gene (deficient in the synthesis of S-adenosylmethionine). 27 proteins have been detected the expression thereof is altered in, at least, 50% of the analysed tumours. Amongst them, 13 proteins have been validated in biopsies of patients with HCC of different etiology, and 7 of them have been validated in biopsies of patients with liver cirrhosis, a stage prior to the development of HCC, which makes it possible to differentiate between prior stages of the disease and even between different etiologies (viral and alcoholic). Having a panel of markers available may contribute to more accurately defining the alterations associated with the development of HCC and thus facilitate prognosis and diagnosis of this disease.
    Type: Application
    Filed: September 28, 2006
    Publication date: July 16, 2009
    Applicant: PROYECTO DE BIOMEDICINA CIMA, S.L.
    Inventors: Fernando Corrales Izquierdo, Enrique Santamaria Martinez, Javier Munoz Peralta, Jesus Prieto Valtuena, Matias Avila Zaragoza
  • Fibrosis Markers
    Publication number: 20090117591
    Abstract: The invention relates to the use of a combination of at least two markers that are selected from among Uromodulin, MAC2BP, AGP1 and Cathepsin A, for the in vitro detection of fibrotic alterations. In addition, the invention relates to a kit for determining the levels of said markers in a biological sample.
    Type: Application
    Filed: June 22, 2006
    Publication date: May 7, 2009
    Applicant: PROYECTO DE BIOMEDICINA CIMA, S.L.
    Inventors: Fernando Corrales Izquierdo, Laura Sesma Aguirre, Joaquin Fernandez Irigoyen, Jesus Prieto Valtuena, Matias Avila Zaragoza
  • USE OF 5'-METHYLTHIOADENOSINE (MTA) IN THE PREVENTION AND/OR TREATMENT OF AUTOIMMUNE DISEASES AND/OR TRANSPLANT REJECTION
    Publication number: 20090042831
    Abstract: 5?-methylthioadenosine (MTA), its pharmaceutically acceptable salts and/or prodrugs may be used in the prevention and/or treatment of autoimmune diseases, such as, for example, Multiple Sclerosis (MS), as well as in the prevention and/or treatment of transplant rejection.
    Type: Application
    Filed: March 17, 2005
    Publication date: February 12, 2009
    Applicant: Proyecto de Biomedicina Cima, S.L.
    Inventors: Pablo Villoslada Diaz, Matias Avila Zaragoza, Beatriz Moreno Bruna, Fernando Corrales Izquierdo, Carmen Berasain Lasarte, Elena Ruiz Garcia-Trevijano
  • Method for Diagnosing Hepatic Diseases
    Publication number: 20080090223
    Abstract: The invention concerns a method for early diagnosis of hepatic diseases, which consists in determining in the samples of the diseased subjects, the presence of a apolipoprotein AI (Apo-AI) isoform, having oxidised W50, W108, and M112 residues. The inventive method is useful for diagnosing hepatocellular carcinoma and hepatitis B.
    Type: Application
    Filed: February 15, 2005
    Publication date: April 17, 2008
    Inventors: Fernando Corrales Izquierdo, Joaquin Fernandez Irigoyen, Enrique Santamaria Martinez, Javier Munoz Peralta, Laura Sesma Aguirre, Jesur Prieto Valtuena, Matias Avila Zaragoza