Patents by Inventor Matej Oslaj

Matej Oslaj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENZYMATIC SYNTHESIS OF ACTIVE PHARMACEUTICAL INGREDIENT AND INTERMEDIATES THEREOF
    Publication number: 20130337485
    Abstract: The present invention discloses a process for preparing an active pharmaceutical ingredient (API) or intermediates thereof, notably particular step in the synthesis of an intermediate useful for example in the preparation of statins, by using an enzyme capable of catalyzing oxidation or dehydrogenation. The invention further provides an expression system effectively translating said enzyme. In addition, the invention relates to a specific use of such enzyme for preparing API or intermediate thereof, and in particular for preparing statin or intermediate thereof.
    Type: Application
    Filed: December 20, 2011
    Publication date: December 19, 2013
    Applicant: LEK PHARMACEUTICALS D.D
    Inventors: Peter Mrak, Tadeja Zohar, Matej Oslaj, Gregor Kopitar
  • Synthesis of statins
    Patent number: 8471045
    Abstract: The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: June 25, 2013
    Assignee: Lek Pharmaceuticals D.D.
    Inventors: Zdenko Casar, Tomaz Mesar, Gregor Kopitar, Peter Mrak, Matej Oslaj
  • ((2,4)-4,6-dihydroxytetrahydro-2-pyran-2-yl)methyl carboxylate and process for the production thereof
    Patent number: 8404870
    Abstract: The present invention relates to ((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)methyl carboxylates and a process for the production thereof. Furthermore, the present invention relates to a process for the production of statins and in particular of Rosuvastatin and derivates thereof, wherein the above mentioned compounds are used as intermediates.
    Type: Grant
    Filed: January 20, 2009
    Date of Patent: March 26, 2013
    Assignee: LEK Pharmaceuticals D.D.
    Inventors: Jerome Cluzeau, Zdenko Casar, Peter Mrak, Matej Oslaj, Gregor Kopitar
  • SYNTHESIS OF STATINS
    Publication number: 20120196333
    Abstract: The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.
    Type: Application
    Filed: March 12, 2012
    Publication date: August 2, 2012
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventors: ZDENKO CASAR, TOMAZ MESAR, GREGOR KOPITAR, PETER MRAK, MATEJ OSLAJ
  • Synthesis of statins
    Patent number: 8183397
    Abstract: The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: May 22, 2012
    Assignee: Lek Pharmaceuticals D.D.
    Inventors: Zdenko Casar, Tomaz Mesar, Gregor Kopitar, Peter Mrak, Matej Oslaj
  • SYNTHESIS OF STATINS
    Publication number: 20110178295
    Abstract: The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.
    Type: Application
    Filed: April 2, 2008
    Publication date: July 21, 2011
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventors: Zdenko Casar, Tomaz Mesar, Gregor Kopitar, Peter Mrak, Matej Oslaj
  • ((2S,4R)-4,6-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL)METHYL CARBOXYLATE AND PROCESS FOR THE PRODUCTION THEREOF
    Publication number: 20110046375
    Abstract: The present invention relates to ((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)methyl carboxylates and a process for the production thereof. Furthermore, the present invention relates to a process for the production of statins and in particular of Rosuvastatin and derivates thereof, wherein the above mentioned compounds are used as intermediates.
    Type: Application
    Filed: January 20, 2009
    Publication date: February 24, 2011
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventors: Jerome Cluzeau, Zdenko Casar, Peter Mrak, Matej Oslaj, Gregor Kopitar