Patents by Inventor Matej Smrkolj

Matej Smrkolj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF EZETIMIBE AND DERIVATIVES THEREOF
    Publication number: 20130190487
    Abstract: The present invention relates to the method of preparing of ezetimibe and in particular to novel intermediates for its synthesis and an improved process for preparing such intermediates. Said intermediates may be obtained in high yields and purity in a fast and cost efficient manner. The present invention relates to a novel crystalline form of ezetimibe as well.
    Type: Application
    Filed: January 24, 2008
    Publication date: July 25, 2013
    Applicant: KRKA
    Inventors: Anton Stimac, Barbara Mohar, Michel Stephan, Mojca Bevc, Rok Zupet, Andrej Gartner, Vesna Kroselj, Matej Smrkolj, Davor Kidemet, Gregor Sedmak, PRIMOZ BENKIC, ALEN KLJAJIC, MIHA PLEVNIK
  • Salts of perindopril
    Patent number: 8470869
    Abstract: The present invention relates to new salts of perindopril, particularly to a new calcium salt and new amine salts of perindopril, to a process for their preparation and to a pharmaceutical formulations containing the new salts.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: June 25, 2013
    Assignee: KRKA, Tovarna Zdravil D.D. Novo Mesto
    Inventors: Marjo Merslavic, Sergeja Bombek, Urska Gojak, Matej Smrkolj, Rok Zupet
  • Isopropanol water solvate of olanzapine
    Patent number: 7906642
    Abstract: The invention relates to a novel and well defined Oolvate form of olanzapine which contains 2 molecules of water and 1 molecule of isopropanol per 2 molecules of olanzapine, and which can be converted into other, forms of olanzapine, in particular form (I) of olanzapine, as well as processes for preparing form (I) olanzapine.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: March 15, 2011
    Assignee: KRKA, Tovarna Zdravil, D.D.
    Inventors: Berta Kotar-Jordan, Roman Lenarsic, Marija Grcman, Matej Smrkolj, Anton Meden, Igor Simonic, Rok Zupet, Joze Gnidovec, Primoz Benkic
  • Sesquihydrate hydrochloride salt of irbesartan
    Patent number: 7875641
    Abstract: The present invention relates to sesquihydrate hydrochloride salt of irbesartan and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: January 25, 2011
    Assignee: KRKA Tovarna Zdravil, D.D., Novo Mesto
    Inventors: Silvo Zupancic, Matej Smrkolj, Renata Jaske
  • Solid pharmaceutical composition comprising donepezil hydrochloride
    Publication number: 20100317694
    Abstract: The invention relates to a solid pharmaceutical composition comprising donepezil hydrochloride hydrate and a process for its preparation. In particular it relates to a composition and a process wherein the donepezil hydrochloride retains its polymorphic form and is therefore highly stable against conversion into other polymorphic forms.
    Type: Application
    Filed: January 20, 2010
    Publication date: December 16, 2010
    Applicant: KRKA, TOVARNA ZDRAVIL, D.D. , NOVO MESTO
    Inventors: Miha Vrbinc, Berta Kotar-Jordan, Rok Zupet, Matej Smrkolj
  • SALTS OF PERINDOPRIL
    Publication number: 20100298400
    Abstract: The present invention relates to new salts of perindopril, particularly to a new calcium salt and new amine salts of perindopril, to a process for their preparation and to a pharmaceutical formulations containing the new salts.
    Type: Application
    Filed: June 27, 2008
    Publication date: November 25, 2010
    Applicant: KRKA, TOVARNA ZDRAVIL D.D. NOVO MESTO
    Inventors: Marjo Merslavic, Sergeja Bombek, Urska Gojak, Matej Smrkolj, Rok Zupet
  • Solid Pharmaceutical Composition Comprising Donepezil Hydrochloride
    Publication number: 20090130205
    Abstract: The invention relates to a solid pharmaceutical composition comprising donepezil hydrochloride hydrate and a process for its preparation. In particular it relates to a composition and a process wherein the donepezil hydrochloride retains its polymorphic form and is therefore highly stable against conversion into other polymorphic forms.
    Type: Application
    Filed: October 19, 2005
    Publication date: May 21, 2009
    Applicant: KRKA, TOVARNA ZDRAVIL D.D., NOVO MESTO
    Inventors: Miha Vrbinc, Berta Kotar-Jordan, Rok Zupet, Matej Smrkolj
  • Preparation of Hydrochloride Salts of Tetrazole Derivative
    Publication number: 20080306128
    Abstract: The present invention relates to sesquihydrate hydrochloride salt of irbesartan and anhydrous hydrochloride salts of irbesartan. Irbesartan used as the starting material for the preparation of the described hydrochlorides of irbesartan can be in any form, e.g. it can be used when contained in a reaction solution, in crude form, in a filtrate containing several solvents, or in anhydrous or any solvated or hydrated form, in amorphous form or any known crystal form or in a mixture thereof.
    Type: Application
    Filed: July 29, 2005
    Publication date: December 11, 2008
    Inventors: Silvo Zupancic, Matej Smrkolj, Renata Jaske
  • Solid Pharmaceutical Composition Comprising Donepezil Hydrochloride
    Publication number: 20080063705
    Abstract: The invention relates to a solid pharmaceutical composition comprising donepezil hydrochloride hydrate and a process for its preparation. In particular it relates to a composition and a process wherein the donepezil hydrochloride retains its polymorphic form and is therefore highly stable against conversion into other polymorphic forms.
    Type: Application
    Filed: October 19, 2005
    Publication date: March 13, 2008
    Applicant: KRKA, TOVARNA ZDRAVIL D.D., NOVO MESTO
    Inventors: Miha Vrbinc, Berta Kotar-Jordan, Rok Zupet, Matej Smrkolj
  • Isopropanol water solvate of olanzapine
    Publication number: 20070191348
    Abstract: The invention relates to a novel and well defined Oolvate form of olanzapine which contains 2 molecules of water and 1 molecule of isopropanol per 2 molecules of olanzapine, and which can be converted into other, forms of olanzapine, in particular form (I) of olanzapine, as well as processes for preparing form (I) olanzapine.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 16, 2007
    Applicant: KRKA, Tovarna Zdravil, D.D.
    Inventors: Berta Kotar-Jordan, Roman Lenarsic, Marija Grcman, Matej Smrkolj, Anton Meden, Igor Simonic, Rok Zupet, Joze Gnidovec, Primoz Benkic