Patents by Inventor Mateusz PUTYRSKI

Mateusz PUTYRSKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PD-L1 variants with improved affinity towards PD-1
    Publication number: 20230174619
    Abstract: The present invention relates to a PD-L1 polypeptide comprising at least a first amino acid sequence at least 70% identical to SEQ ID NO:8, and at least a second sequence at least 70% identical to SEQ ID NO: 10, wherein the polypeptide carries amino acid substitutions at least at the amino acid positions Y56 and P76, wherein the amino acid positions are based on the murine PD-L1 amino acid sequence (SEQ ID NO:6). The present invention also relates to a polynucleotide encoding the aforesaid PD-L1 polypeptide, and to host cells, methods, and uses related thereto.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 8, 2023
    Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.
    Inventors: Mateusz PUTYRSKI, Andreas ERNST, Svenja WIECHMANN, Andreas VON KNETHEN, Michael John PARNHAM
  • Antibody inhibitors of IL-38 and methods of use thereof for treating or reducing the likelihood of cancer in a subject
    Patent number: 11427630
    Abstract: An inhibitor of IL-38 is useful for treating and/or preventing cancer in a subject. A pharmaceutical composition can include an inhibitor of IL-38. A method for treating and/or preventing cancer is carried out by administering an inhibitor of IL-38 in a therapeutically effective amount. Another method is useful for identifying an inhibitor of IL-38.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: August 30, 2022
    Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Andreas Weigert, Javier Mora, Bernhard Brüne, Mateusz Putyrski, Michael John Parnham, Andreas Ernst
  • INHIBITORS OF IL-38 FOR USE IN TREATING AND/OR PREVENTING CANCER IN A SUBJECT
    Publication number: 20200165334
    Abstract: An inhibitor of IL-38 is useful for treating and/or preventing cancer in a subject. A pharmaceutical composition can include an inhibitor of IL-38. A method for treating and/or preventing cancer is carried out by administering an inhibitor of IL-38 in a therapeutically effective amount. Another method is useful for identifying an inhibitor of IL-38.
    Type: Application
    Filed: May 7, 2018
    Publication date: May 28, 2020
    Inventors: Andreas WEIGERT, Javier MORA, Bernhard BRÜNE, Mateusz PUTYRSKI, Michael John PARNHAM, Andreas ERNST