Abstract: An injection device comprising a housing (1) and a cartridge holder (2, 20), the housing (1) being provided on the proximal side with a rotatable dose knob (4, 40) and an axially translatable button (5, 50). The housing (1) comprises: a dose setting sleeve (6, 60), a non-rotatable tubular driving element (7, 70) slidingly mounted in the housing (1) and engaged with the dose setting sleeve (6, 60) by a threaded connection, a non-rotatable axially sliding piston rod (15,150), a toothed gear (8, 80) comprising teeth (8.1, 80.1), a driving spring (13, 130). The dose setting sleeve (6, 60) is equipped with at least one ratchet arm (6.4, 60.4) cooperating with the toothed gear (8, 80); the piston rod (15, 150) has at least one row of ratchet teeth (15.1, 150.1) on its external surface; the driving element (7, 70) is on its distal side fixedly connected with at least one driving arm (14, 140) cooperating with the ratchet teeth (15.1, 150.1) of the piston rod (15, 150).

Abstract: A drive mechanism for an applicator for delivering a dose of a medicament, comprising: a dose setting assembly (N), a knob (1), a rotatable and axially non-translatable clutch element (2) coupled in rotation with the knob (1) and cooperating with the dose setting assembly (N), a rotatable piston rod (3) having an external thread (3.2), the piston rod (3) being located inside the clutch element (2), a drive element (4) and a drive spring (5), wherein when a dose is being set (1) by means of the knob (1), the clutch element (2) is rotated so that the drive spring (5) is loaded, while the drive element (4) and the piston rod (3) are immobilized, and when the dose is being delivered, the drive spring (5) is being released causing the drive element (4) to rotate together with the piston rod (3), the piston rod (3) being moved axially in a distal direction, wherein the piston rod (3) is hollow and has an internal thread (3.3) and a shaft (21) having an external thread (21.

Abstract: A drive-control system for an injection device for delivering settable doses of a pharmaceutical substance contained in a cartridge, including a tubular housing body having a longitudinal axis, a proximal end and a distal end connectable to the cartridge enclosure, a helical spring contained in the housing body and a piston rod moveable towards the distal end and blocked in translation towards the proximal end. The housing body includes a control sleeve on which the spring is mounted, which rotatable around the axis, and a setting sleeve translatable along the axis. Rotation of the control sleeve in a first direction combined with compression of the spring causes the setting sleeve to be translated towards the proximal end of the housing body, and extension of the spring causes the setting sleeve to be translated towards the distal end of the housing body and the control sleeve to be rotated in a second direction and the piston rod to be pushed towards the outside of the housing body.

Abstract: A drive mechanism for an applicator for delivering multiple doses of medicament, comprising an axially moveable piston rod (2) having a non-circular cross-section and an external thread, a mounting member (4) with one member of a pair of blocking means, said pair comprising a toothed rim (4a, 3b) and at least one ratchet arm (3a, 4b); a drive sleeve (3) having an internal thread coupled with the thread of the piston rod (2), the drive sleeve (3) provided on the distal end with the other member of said pair of blocking means. A method of assembling the drive mechanism of the invention, in which the drive sleeve (3) together with the piston rod (2) and the piston rod guide (5) into the mounting member (4) are inserted from the side of the distal end of the applicator.

Abstract: A drive-control system for an injection device for delivering settable doses of a pharmaceutical substance contained in a cartridge, including a tubular housing body having a longitudinal axis, a proximal end and a distal end connectable to the cartridge enclosure, a helical spring contained in the housing body and a piston rod moveable towards the distal end and blocked in translation towards the proximal end. The housing body includes a control sleeve on which the spring is mounted, which rotatable around the axis, and a setting sleeve translatable along the axis. Rotation of the control sleeve in a first direction combined with compression of the spring causes the setting sleeve to be translated towards the proximal end of the housing body, and extension of the spring causes the setting sleeve to be translated towards the distal end of the housing body and the control sleeve to be rotated in a second direction and the piston rod to be pushed towards the outside of the housing body.

Abstract: A drive-control system for an injection device for delivering settable doses of a pharmaceutical substance contained in a cartridge (3), the system comprising a tubular housing body (2) having a longitudinal axis (A-A), a proximal end (2a) and a distal end (2b) connectable to the cartridge enclosure (3), the system further comprising a helical spring (7) contained in the housing body and a piston rod (6) moveable towards said distal end (2b) and blocked in translation towards the proximal end (2a).

Abstract: A setting mechanism for a dosing device, in particular for a device for dosing pharmaceutical or therapeutic substances, the setting mechanism including: a controlling assembly for connecting the setting mechanism with a dose setting element of the dosing device; a driving assembly for connecting the setting mechanism with a driving element of the dosing device; a dosing assembly for connecting the setting mechanism with a dosing element of the dosing device. The controlling assembly is coupled with the dosing assembly by a spring element, which can deform from a coupled position to a decoupled position during rotation of the dose setting element. The spring element is configured to allow a displacement of the controlling assembly with respect to the dosing assembly. In the coupled position the spring element is configured to block a rotation of the controlling assembly with respect to the dosing assembly.

Abstract: A drive-control system for an injection device for delivering set-table doses of a pharmaceutical substance contained in a cartridge (3), the system comprising a tubular housing body (2) having a longitudinal axis (A-A), a proximal end (2a) and a distal end (2b) connectable to the cartridge enclosure (3), the system further comprising a helical spring (7) contained in the housing body and a piston rod (6) moveable towards said distal end (2b) and blocked in translation towards the proximal end (2a).

Abstract: A setting mechanism for a dosing device, in particular for a device for dosing pharmaceutical or therapeutic substances, the setting mechanism including: a controlling assembly for connecting the setting mechanism with a dose setting element of the dosing device; a driving assembly for connecting the setting mechanism with a driving element of the dosing device; a dosing assembly for connecting the setting mechanism with a dosing element of the dosing device. The controlling assembly is coupled with the dosing assembly by a spring element, which can deform from a coupled position to a decoupled position during rotation of the dose setting element. The spring element is configured to allow a displacement of the controlling assembly with respect to the dosing assembly. In the coupled position the spring element is configured to block a rotation of the controlling assembly with respect to the dosing assembly.