Patents by Inventor Matheus Esteves Ferreira
Matheus Esteves Ferreira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11906515Abstract: A multiplexed lateral flow device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir. The fluid distributor pad includes a paper based microfluidic element having a pattern of a hydrophobic material to distribute a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays.Type: GrantFiled: April 9, 2020Date of Patent: February 20, 2024Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, FUNDACAO OSWALDO CRUZInventors: Jaione Tirapu Azpiroz, Ademir Ferreira da Silva, Matheus Esteves Ferreira, Ricardo Luis Ohta, Mathias B. Steiner, Antonio Gomes Pinto Ferreira, Edimilson Domingos da Silva, Nara Mazarakis Rubim, Pedro Paulo Ferreira Ribeiro
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Patent number: 11709819Abstract: A validation method applied to sensor data prior to submitting to a blockchain, a computer program product, and a system for validating chemical data. One embodiment may comprise receiving a sensor captured result at an application, applying the sensor captured result to a domain-specific statistical model of expected range of variability of measured results to extract a distribution of expected sensor values, computing a confidence value in the sensor captured result using the domain-specific statistical model, validating the confidence value against a required threshold of confidence, and submitting the sensor captured result for appending to the blockchain if the confidence level is validated against the threshold of confidence.Type: GrantFiled: September 30, 2020Date of Patent: July 25, 2023Assignee: International Business Machines CorporationInventors: Jaione Tirapu Azpiroz, Ademir Ferreira da Silva, Percival Silva de Lucena, Matheus Esteves Ferreira, Ricardo Luis Ohta, Mathias B Steiner
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Patent number: 11648562Abstract: Method, apparatus, and computer program product are provided for anonymized diagnosis using lateral flow assays. In some embodiments, a test card includes one or more lateral flow assay (LFA) with one or more test patterns (e.g., full line, partial line, dot), one or more dummy patterns, and one or more control patterns. To visually encode LFA results, at manufacture, one or more lines/dots containing true results of the LFA(s) each has a position mixed with other “dummy” lines/dots, in randomized position patterns selected from among a plurality of possible position patterns. An optical machine-readable representation of data (e.g., QR code) is attached to the test card and encodes test card identification information (e.g., lot number, serial number, test type) associated with the test card. In some embodiments, a passcode card having a scrapeable coating that conceals a passcode associated with the test card is removably attached to the test card.Type: GrantFiled: November 1, 2019Date of Patent: May 16, 2023Assignee: International Business Machines CorporationInventors: Ricardo L. Ohta, Jaione Tirapu Azpiroz, Ademir F. Silva, Matheus Esteves Ferreira, Mathias B. Steiner
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Patent number: 11618032Abstract: A multiplexed testing strip testing device includes a hydrophobic paper-based strip housing element configured for placement of one or more testing strips. One or more alignment markers on the hydrophobic paper-based housing element are marked to facilitate placement of the one or more testing strips. A cover element is arranged above the strip housing element and includes a machine-readable test identifier on an upper surface. A removably attached filtering element is arranged on the hydrophobic paper-based strip housing element.Type: GrantFiled: August 31, 2020Date of Patent: April 4, 2023Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Jaione Tirapu Azpiroz, Matheus Esteves Ferreira, Ademir Ferreira da Silva, Daniel Vitor Lopes Marcondes Marçal, Ricardo Luis Ohta, Mathias B. Steiner
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Publication number: 20230030730Abstract: An embodiment includes a sample receiving region, a first diagnostic element that includes one or more colorimetric analysis regions, and a second diagnostic element that includes one or more lateral flow assay analysis regions. The embodiment also includes a first flow path that allows a portion of a liquid deposited at the sample receiving region to flow to the first diagnostic element. The embodiment also includes a second flow path that allows a portion of the liquid deposited at the sample receiving region to flow to the second diagnostic element.Type: ApplicationFiled: October 7, 2022Publication date: February 2, 2023Applicant: International Business Machines CorporationInventors: Ademir Ferreira da Silva, JAIONE TIRAPU AZPIROZ, Matheus Esteves Ferreira, Mathias B. Steiner, Daniel Vitor Lopes Marcondes Marçal
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Patent number: 11554371Abstract: Devices and methods for controlling collection of liquid sample are described. In an example, a microfluidic device can include an analytical device and an actuator. The actuator can be connected to the analytical device. The actuator can be operable to absorb fluid. The actuator can guide the absorbed fluid to an input layer of the analytical device. The actuator can deform in response to an occurrence of an absorption condition. A degree of deformation of the actuator indicates a volume of fluid collected by the analytical device.Type: GrantFiled: December 30, 2020Date of Patent: January 17, 2023Assignee: International Business Machines CorporationInventors: Ricardo Luis Ohta, Jaione Tirapu Azpiroz, Matheus Esteves Ferreira, Daniel Vitor Lopes Marcondes Marçal, Ademir Ferreira Da Silva, Mathias B Steiner
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Patent number: 11549943Abstract: A multiplexed lateral flow assay device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir and divides a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable paper top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays. The housing element includes an impermeable bottom cover and a spacer element arranged between the top and bottom covers and, provides a gap between the lateral flow assays and the impermeable paper top cover.Type: GrantFiled: May 31, 2019Date of Patent: January 10, 2023Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, FUNDACAO OSWALDO CRUZInventors: Jaione Tirapu Azpiroz, Ademir Ferreira da Silva, Matheus Esteves Ferreira, Ricardo Luis Ohta, Mathias B. Steiner, Nara Mazarakis Rubim, Pedro Paulo Ferreira Ribeiro, Edimilson Domingos da Silva, Antonio Gomez Pinto Ferreira
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Patent number: 11534752Abstract: An embodiment includes a sample receiving region, a first diagnostic element that includes one or more colorimetric analysis regions, and a second diagnostic element that includes one or more lateral flow assay analysis regions. The embodiment also includes a first flow path that allows a portion of a liquid deposited at the sample receiving region to flow to the first diagnostic element. The embodiment also includes a second flow path that allows a portion of the liquid deposited at the sample receiving region to flow to the second diagnostic element.Type: GrantFiled: December 30, 2020Date of Patent: December 27, 2022Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Ademir Ferreira da Silva, Jaione Tirapu Azpiroz, Matheus Esteves Ferreira, Mathias B Steiner, Daniel Vitor Lopes Marcondes Marçal
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Patent number: 11498069Abstract: A rapid test device includes a micropad chip configured for a multi-parameter chemical testing of an input sample. A plurality of paper layers of the micropad chip are in fluid communication, including a sample absorption element, a filtering element configured to filter the input sample, and a sample distribution element configured to distribute the input sample received from the filtering element to a remainder of the plurality of paper layers. One or more reacting elements associated with the multi-parameter chemical testing of the input sample have one or more colorimetric reagents in fluid communication with the sample distribution element. A colorimetric result displaying element in fluid communication with the one or more reacting elements is configured to display a colorimetric result of the testing of the input sample with the at least one reacting element for a respective chemical test of the multi-parameter chemical testing.Type: GrantFiled: August 31, 2020Date of Patent: November 15, 2022Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Ademir Ferreira da Silva, Daniel Vitor Lopes Marcondes Marçal, Jaione Tirapu Azpiroz, Matheus Esteves Ferreira, Mathias B. Steiner, Ricardo Luis Ohta
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Patent number: 11376582Abstract: Fabricating a fluid testing device includes receiving a substrate, and applying a pattern of hydrophobic material to the substrate. The substrate is positioned between layers of a thermally reflective material. Heat and pressure is applied to the substrate and thermally reflective material to reflow the pattern of hydrophobic material. A protective coating is applied over a portion of the substrate to form the fluid testing device.Type: GrantFiled: March 5, 2019Date of Patent: July 5, 2022Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Jaione Tirapu Azpiroz, Matheus Esteves Ferreira, Ademir Ferreira da Silva, Ricardo Luis Ohta, Mathias Steiner
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Publication number: 20220203353Abstract: An embodiment includes a sample receiving region, a first diagnostic element that includes one or more colorimetric analysis regions, and a second diagnostic element that includes one or more lateral flow assay analysis regions. The embodiment also includes a first flow path that allows a portion of a liquid deposited at the sample receiving region to flow to the first diagnostic element. The embodiment also includes a second flow path that allows a portion of the liquid deposited at the sample receiving region to flow to the second diagnostic element.Type: ApplicationFiled: December 30, 2020Publication date: June 30, 2022Applicant: International Business Machines CorporationInventors: Ademir Ferreira da Silva, JAIONE TIRAPU AZPIROZ, Matheus Esteves Ferreira, Mathias B. Steiner, Daniel Vitor Lopes Marcondes Marçal
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Publication number: 20220203358Abstract: Devices and methods for controlling collection of liquid sample are described. In an example, a microfluidic device can include an analytical device and an actuator. The actuator can be connected to the analytical device. The actuator can be operable to absorb fluid. The actuator can guide the absorbed fluid to an input layer of the analytical device. The actuator can deform in response to an occurrence of an absorption condition. A degree of deformation of the actuator indicates a volume of fluid collected by the analytical device.Type: ApplicationFiled: December 30, 2020Publication date: June 30, 2022Inventors: Ricardo Luis Ohta, Jaione Tirapu Azpiroz, Matheus Esteves Ferreira, Daniel Vitor Lopes Marcondes Marçal, Ademir Ferreira da Silva, Mathias B. Steiner
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Patent number: 11366943Abstract: A computer-implemented method, computer program product and prototyping platform creates a design blueprint for a substrate-based microfluidic device. A design and prototyping platform receives at least one blueprint parameter and at least one constraint associated with a proposed substrate-based microfluidic device including a hydrophilic material and arrangement of a pattern of a hydrophobic material. The platform determines an arrangement of a plurality of microfluidic device elements as candidates for implementation of the proposed substrate-based microfluidic device and outputs a design blueprint of the proposed substrate-based microfluidic device.Type: GrantFiled: June 18, 2019Date of Patent: June 21, 2022Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Jaione Tirapu Azpiroz, Ademir Ferreira da Silva, Matheus Esteves Ferreira, Ricardo Luis Ohta, Mathias B. Steiner
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Publication number: 20220100731Abstract: A validation method applied to sensor data prior to submitting to a blockchain, a computer program product, and a system for validating chemical data. One embodiment may comprise receiving a sensor captured result at an application, applying the sensor captured result to a domain-specific statistical model of expected range of variability of measured results to extract a distribution of expected sensor values, computing a confidence value in the sensor captured result using the domain-specific statistical model, validating the confidence value against a required threshold of confidence, and submitting the sensor captured result for appending to the blockchain if the confidence level is validated against the threshold of confidence.Type: ApplicationFiled: September 30, 2020Publication date: March 31, 2022Inventors: JAIONE TIRAPU AZPIROZ, Ademir Ferreira da Silva, Percival Silva de Lucena, Matheus Esteves Ferreira, Ricardo Luis Ohta, Mathias B. Steiner
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Publication number: 20220062897Abstract: A rapid test device includes a micropad chip configured for a multi-parameter chemical testing of an input sample. A plurality of paper layers of the micropad chip are in fluid communication, including a sample absorption element, a filtering element configured to filter the input sample, and a sample distribution element configured to distribute the input sample received from the filtering element to a remainder of the plurality of paper layers. One or more reacting elements associated with the multi-parameter chemical testing of the input sample have one or more colorimetric reagents in fluid communication with the sample distribution element. A colorimetric result displaying element in fluid communication with the one or more reacting elements is configured to display a colorimetric result of the testing of the input sample with the at least one reacting element for a respective chemical test of the multi-parameter chemical testing.Type: ApplicationFiled: August 31, 2020Publication date: March 3, 2022Inventors: Ademir Ferreira da Silva, Daniel Vitor Lopes Marcondes Marçal, Jaione Tirapu Azpiroz, Matheus Esteves Ferreira, Mathias B. Steiner, Ricardo Luis Ohta
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Publication number: 20220062911Abstract: A multiplexed testing strip testing device includes a hydrophobic paper-based strip housing element configured for placement of one or more testing strips. One or more alignment markers on the hydrophobic paper-based housing element are marked to facilitate placement of the one or more testing strips. A cover element is arranged above the strip housing element and includes a machine-readable test identifier on an upper surface. A removably attached filtering element is arranged on the hydrophobic paper-based strip housing element.Type: ApplicationFiled: August 31, 2020Publication date: March 3, 2022Inventors: Jaione Tirapu Azpiroz, Matheus Esteves Ferreira, Ademir Ferreira da Silva, Daniel Vitor Lopes Marcondes Marçal, Ricardo Luis Ohta, Mathias B. Steiner
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Patent number: 11060968Abstract: A target sample to be chemically analyzed is received at a microfluidic device which is part of an analysis card. The microfluidic device includes at least one input layer configured to receive the target sample, at least one intermediary layer, and at least one readout layer configured to present one or more color attributes at one or more readout regions in response to one or more colorimetric reactions to the target sample. An image of the readout layer of the microfluidic device is obtained. A calibration file that corresponds to the analysis card is obtained. The calibration file includes a calibrated model of at least one color attribute based on data from at least one known chemical attribute of at least one standard sample processed by a calibration card.Type: GrantFiled: March 30, 2018Date of Patent: July 13, 2021Assignee: International Business Machines CorporationInventors: Ricardo Luis Ohta, Ademir Ferreira da Silva, Andre de Oliveira Botelho, Matheus Esteves Ferreira, Jaione Tirapu Azpiroz, Michael Engel, Mathias Steiner
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Publication number: 20210129133Abstract: Method, apparatus, and computer program product are provided for anonymized diagnosis using lateral flow assays. In some embodiments, a test card includes one or more lateral flow assay (LFA) with one or more test patterns (e.g., full line, partial line, dot), one or more dummy patterns, and one or more control patterns. To visually encode LFA results, at manufacture, one or more lines/dots containing true results of the LFA(s) each has a position mixed with other “dummy” lines/dots, in randomized position patterns selected from among a plurality of possible position patterns. An optical machine-readable representation of data (e.g., QR code) is attached to the test card and encodes test card identification information (e.g., lot number, serial number, test type) associated with the test card. In some embodiments, a passcode card having a scrapeable coating that conceals a passcode associated with the test card is removably attached to the test card.Type: ApplicationFiled: November 1, 2019Publication date: May 6, 2021Inventors: Ricardo L. Ohta, Jaione Tirapu Azpiroz, Ademir F. Silva, Matheus Esteves Ferreira, Mathias B. Steiner
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Publication number: 20200401670Abstract: A computer-implemented method, computer program product and prototyping platform creates a design blueprint for a substrate-based microfluidic device. A design and prototyping platform receives at least one blueprint parameter and at least one constraint associated with a proposed substrate-based microfluidic device including a hydrophilic material and arrangement of a pattern of a hydrophobic material. The platform determines an arrangement of a plurality of microfluidic device elements as candidates for implementation of the proposed substrate-based microfluidic device and outputs a design blueprint of the proposed substrate-based microfluidic device.Type: ApplicationFiled: June 18, 2019Publication date: December 24, 2020Inventors: Jaione Tirapu Azpiroz, Ademir Ferreira da Silva, Matheus Esteves Ferreira, Ricardo Luis Ohta, Mathias B. Steiner
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Publication number: 20200376485Abstract: A multiplexed lateral flow device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir. The fluid distributor pad includes a paper based microfluidic element having a pattern of a hydrophobic material to distribute a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays.Type: ApplicationFiled: April 9, 2020Publication date: December 3, 2020Inventors: Jaione Tirapu Azpiroz, Ademir Ferreira da Silva, Matheus Esteves Ferreira, Ricardo Luis Ohta, Mathias B. Steiner, Antonio Gomes Pinto Ferreira, Edimilson Domingos da Silva, Nara Mazarakis Rubim, Pedro Paulo Ferreira Ribeiro