Patents by Inventor Mathew G. Miller

Mathew G. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T7 RNA POLYMERASE VARIANTS
    Publication number: 20190002850
    Abstract: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5?)ppp(5?)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.
    Type: Application
    Filed: June 19, 2018
    Publication date: January 3, 2019
    Inventors: Mathew G. Miller, Chinping Chng, Oscar Alvizo, Melissa Ann Mayo, James Nicholas Riggins, Xiang Yi, Jonathan S. Penfield, Gjalt W. Huisman, Jared Davis, Yasushi Saotome
  • T7 RNA POLYMERASE VARIANTS
    Publication number: 20190002851
    Abstract: The present invention provides engineered T7 RNA polymerase variants and compositions thereof. These variants have been evolved for selective incorporation of the symmetrical capped GTP analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for using the variants provided herein. The present invention further provides for the use of the compositions provided herein.
    Type: Application
    Filed: June 19, 2018
    Publication date: January 3, 2019
    Inventors: Mathew G. Miller, Chinping Chng, Oscar Alvizo, Melissa Ann Mayo, James Nicholas Riggins, Xiang Yi, Jonathan S. Penfield, Gjalt W. Huisman
  • ENGINEERED LIGASE VARIANTS
    Publication number: 20180320162
    Abstract: The present invention provides engineered ligase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered ligase polypeptides. The invention also provides methods for use of the compositions comprising the engineered ligase polypeptides for diagnostic and other purposes.
    Type: Application
    Filed: May 7, 2018
    Publication date: November 8, 2018
    Inventors: Mathew G. Miller, Jonathan Vroom, Nikki Dellas, Donald S. Baskerville, Sandy M. Gomes, David Elgart, Judy Victoria Antonio Viduya
  • HUMAN ALPHA-GALACTOSIDASE VARIANTS
    Publication number: 20170360900
    Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH <4.5) and basic (pH >7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
    Type: Application
    Filed: December 2, 2015
    Publication date: December 21, 2017
    Inventors: Nicholas J. Agard, Mathew G. Miller, Xiyun Zhang, Gjalt W. Huisman
  • Pentose fermentation by a recombinant microorganism
    Patent number: 9611515
    Abstract: The present invention provides methods and compositions suitable for use in the isomerization of xylose to xylulose, as well as methods and compositions suitable for use in the conversion of xylose to xylitol and xylulose, including nucleic acid constructs, recombinant fungal host cells, and related materials.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: April 4, 2017
    Assignee: Codexis, Inc.
    Inventors: Oscar Alvizo, Mathew G. Miller, Benjamin N. Mijts, Galit Meshulam-Simon, Robert McDaniel
  • PENTOSE FERMENTATION BY A RECOMBINANT MICROORGANISM
    Publication number: 20150337340
    Abstract: The present invention provides methods and compositions suitable for use in the isomerization of xylose to xylulose, as well as methods and compositions suitable for use in the conversion of xylose to xylitol and xylulose, including nucleic acid constructs, recombinant fungal host cells, and related materials.
    Type: Application
    Filed: November 14, 2013
    Publication date: November 26, 2015
    Inventors: Oscar Alvizo, Mathew G. Miller, Benjamin N. Mijts, Galit Meshulam-Simon, Robert McDaniel