Patents by Inventor Mathew H. Delano
Mathew H. Delano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230393104Abstract: A device for processing samples is disclosed. Interior surfaces of the device, which come in contact with fluids, define wetted surfaces. A portion of the wetted surfaces are coated with an alkylsilyl coating having the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20-, —(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.Type: ApplicationFiled: June 7, 2023Publication date: December 7, 2023Applicant: Waters Technologies CorporationInventors: Xiaoxiao Liu, Anna Boardman, Mathew H. DeLano, Matthew A. Lauber
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Publication number: 20230393103Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20, -(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or -(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.Type: ApplicationFiled: June 7, 2023Publication date: December 7, 2023Applicant: Waters Technologies CorporationInventors: Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan Belanger, Theodore A. Dourdeville, Kerri Smith, Paul Rainville, Dimple Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
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Patent number: 11709155Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.Type: GrantFiled: September 17, 2018Date of Patent: July 25, 2023Assignee: Waters Technologies CorporationInventors: Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan L. Belanger, Theodore A. Dourdeville, Kerri M. Smith, Paul D. Rainville, Dimple D. Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
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Patent number: 11709156Abstract: A device for processing samples is disclosed. Interior surfaces of the device, which come in contact with fluids, define wetted surfaces. A portion of the wetted surfaces are coated with an alkylsilyl coating having the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20—.Type: GrantFiled: January 17, 2020Date of Patent: July 25, 2023Assignee: Waters Technologies CorporationInventors: Xiaoxiao Liu, Anna Boardman, Mathew H. DeLano, Matthew A. Lauber
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Patent number: 11389747Abstract: The invention provides filters and methods of assembling filters. In an exemplary embodiment, the filter includes a porous element, a compression element, and a housing. The compression element can be configured to receive the porous element, thereby forming an assembly. For example, the compression element can receive the porous element in a slip-fit relationship. The housing can have an opening formed therein that is configured to receive the assembly. In some embodiments, the assembly can be retained within the opening when the assembly is received therein. For example, the opening can receive the assembly in a press-fit relationship.Type: GrantFiled: June 6, 2014Date of Patent: July 19, 2022Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Mathew H. Delano, Jonathan Belanger, Raymond P. Fisk
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Publication number: 20220118443Abstract: The present disclosure is directed to a coating process for chromatographic surfaces. Embodiments of the present disclosure feature a two-step, vapor-liquid phase organosilane deposition method for creating a hydrophilic, non-ionic surface in a chromatographic system.Type: ApplicationFiled: October 15, 2021Publication date: April 21, 2022Applicant: Waters Technologies CorporationInventors: Mathew H. DeLano, Matthew Lauber, Andrew Wyatt Schmudlach, Daniel P. Walsh, Yeliz Tunc Sarisozen, Jonathan Belanger, Darryl W. Brousmiche, Andrew Bates-Harrison, Nicole L. Lawrence
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Publication number: 20210325352Abstract: Chromatographic systems for size exclusion chromatography (SEC) are provided that comprise an inlet, an outlet, an analytic column having a first interior volume that has a first length and a first cross-sectional area normal to the first length, the first interior volume containing a first stationary phase, and a guard column having a second interior volume that has a second length and a second cross-sectional area normal to the second length, the second interior volume containing a second stationary phase. The inlet is in fluid communication with the guard column, the guard column is in fluid communication with the analytic column, and the analytic column is in fluid communication with the outlet. Moreover, the second length is smaller than the first length, and the second cross-sectional area is smaller than the first cross-sectional area.Type: ApplicationFiled: April 15, 2021Publication date: October 21, 2021Inventors: Stephen James Shiner, Frank J. Marszalkowski, Jr., Steven M. Byrd, Raymond P. Fisk, Mathew H. DeLano, Lavelay Kizekai
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Publication number: 20200406252Abstract: A sample preparation device is provided for enriching a component of a sample. The sample preparation device includes a surface in fluid communication with the sample, an alkylsilyl coating disposed on the surface, and an affinity ligand or an enzyme covalently bonded to the alkylsilyl coating.Type: ApplicationFiled: June 26, 2020Publication date: December 31, 2020Applicant: Waters Technologies CorporationInventors: Matthew A. Lauber, Mathew H. DeLano, Beatrice Muriithi, Xiaoxiao Liu, Anna Boardman
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Publication number: 20200269157Abstract: The present disclosure relates to a filter. The filter includes a porous element, a compression element and a housing. At least a portion of the porous element is coated with an alkylsilyl coating. The compression element is configured to receive the porous element thereby forming an assembly. The housing has an opening formed therein. The opening is configured to receive the assembly. The assembly is retained within the opening when the assembly is received therein.Type: ApplicationFiled: February 25, 2020Publication date: August 27, 2020Applicant: Waters Technologies CorporationInventors: Mathew H. DeLano, Matthew A. Lauber, Michael Donegan, Robert A. Jencks, Stephen J. Shiner
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Publication number: 20200271629Abstract: The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. The method includes introducing a sample comprising the analytes into a chromatographic system. The chromatographic system has a flow path disposed in an interior of the chromatographic system, at least a portion of the flow path having an active coating, and a chromatographic column having a stationary phase material in an interior of the chromatographic column that facilitates separation of the analytes in the sample through interaction with at least one analyte in the sample. The active coating is selected to interact with at least one analyte in the sample through (1) a repulsive force, (2) a secondary interaction, or (3) a retention mechanism distinct from the interaction with the stationary phase material.Type: ApplicationFiled: February 25, 2020Publication date: August 27, 2020Applicant: Waters Technologies CorporationInventors: Matthew A. Lauber, Martin Gilar, Mathew H. DeLano, Michael Donegan
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Publication number: 20200215457Abstract: A method of separating a sample is disclosed. The method includes introducing the sample to a fluidic system including a flow path disposed in an interior of the fluidic system, the flow path including an alkylsilyl coating covering wetted surfaces and deposited on the wetted surfaces by thermal decomposing a carbosilane followed by oxidizing the wetted surface, and the alkylsilyl coating is inert to at least one analyte in the sample.Type: ApplicationFiled: January 17, 2020Publication date: July 9, 2020Applicant: Waters Technologies CorporationInventors: Mathew H. DeLano, Michael Donegan, Matthew A. Lauber
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Publication number: 20200217827Abstract: A device for processing samples is disclosed. Interior surfaces of the device, which come in contact with fluids, define wetted surfaces. A portion of the wetted surfaces are coated with an alkylsilyl coating having the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20—.Type: ApplicationFiled: January 17, 2020Publication date: July 9, 2020Applicant: Waters Technologies CorporationInventors: Xiaoxiao Liu, Anna Boardman, Mathew H. DeLano, Matthew A. Lauber
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Patent number: 10386344Abstract: The invention relates to tubing assemblies and methods for forming a fluidic connection to make the same. The assemblies include an outer tube having disposed therein a first inner tube affixed to the outer tube, a second inner tube and a support tube disposed in the second inner tube. The second inner tube is abutted against the first inner tube. A radial crimp is made in the outer tube over the second inner tube a distance x from where the tubes abut; the distance x being such that the end of the second inner tube seals against the end of the first inner tube. Various embodiments provide assemblies suitable for use with high fluidic pressure (e.g., greater than an about 70 MPa, approximately about 10,000 psi) and formation of chromatographic column assemblies comprising a capillary tube predisposed within the first or second inner tube prior to formation of the seal.Type: GrantFiled: June 8, 2018Date of Patent: August 20, 2019Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Wade P. Leveille, Mathew H. DeLano
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Publication number: 20190086371Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.Type: ApplicationFiled: September 17, 2018Publication date: March 21, 2019Applicant: Waters Technologies CorporationInventors: Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan L. Belanger, Theodore A. Dourdeville, Kerri M. Smith, Paul D. Rainville, Dimple D. Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
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Publication number: 20180356376Abstract: The invention relates to tubing assemblies and methods for forming a fluidic connection to make the same. The assemblies include an outer tube having disposed therein a first inner tube affixed to the outer tube, a second inner tube and a support tube disposed in the second inner tube. The second inner tube is abutted against the first inner tube. A radial crimp is made in the outer tube over the second inner tube a distance x from where the tubes abut; the distance x being such that the end of the second inner tube seals against the end of the first inner tube. Various embodiments provide assemblies suitable for use with high fluidic pressure (e.g., greater than an about 70 MPa, approximately about 10,000 psi) and formation of chromatographic column assemblies comprising a capillary tube predisposed within the first or second inner tube prior to formation of the seal.Type: ApplicationFiled: June 8, 2018Publication date: December 13, 2018Inventors: Wade P. Leveille, Mathew H. DeLano
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Publication number: 20160114262Abstract: The invention provides filters and methods of assembling filters. In an exemplary embodiment, the filter includes a porous element, a compression element, and a housing. The compression element can be configured to receive the porous element, thereby forming an assembly. For example, the compression element can receive the porous element in a slip-fit relationship. The housing can have an opening formed therein that is configured to receive the assembly. In some embodiments, the assembly can be retained within the opening when the assembly is received therein. For example, the opening can receive the assembly in a press-fit relationship.Type: ApplicationFiled: June 6, 2014Publication date: April 28, 2016Applicant: Waters Technologies CorporationInventors: Mathew H. Delano, Jonathan Belanger, Raymond P. Fisk