Abstract: A support system configured to support the lower extremities of a patient, for example during radiotherapy and imaging procedures, and methods for employing the same is provided. The support system includes a knee support apparatus and a foot support apparatus, each of which may be used together or independently in order to customize the support needed for the particular procedure. When used on the patient table of an appropriate imaging or treatment modality, the support system is configured to allow the clinician to independently adjust the knee support and foot support's positioning in the superior-inferior axis of the patient table in both a gross and fine manner for optimal positioning of the patient for the target procedure. The robust adjustment capabilities of the support system enable enhanced patient comfort, setup reproducibility, and workflow efficiency.