Patents by Inventor Mathews Brown

Mathews Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11090509
    Abstract: A cancer treatment apparatus has a neutron source generating neutrons exiting through a surface of a moderator block and an elongated beam-shaping apparatus (BSA) having a length and a circular cross section of a diameter less than the length, the BSA joined at one end to and projecting orthogonally from the surface of the moderator block of the neutron source, the BSA having a conically shaped element at an end away from the moderator block, the conically shaped element declining in diameter in a direction away from the moderator block. Neutrons produced by the neutron source enter the BSA at the surface of the moderator block, travel the length of the BSA, and exit the BSA through an aperture at the end of the BSA away from the moderator block.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: August 17, 2021
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Jay Theodore Cremer, Jr., Charles Kevin Gary, David Lowndes Williams, Allan Xi Chen, Glenn Emerson Jones, Jr., Yao Zong Guan, Randall Scott Urdahl, Adam Nathaniel Amoroso
  • Patent number: 10955365
    Abstract: A neutron generator has a neutron source generating an ion beam bombarding a Titanium target having a first diameter, the target embedded in a pre-moderator, emitting fast neutrons isotropically, a portion of the fast neutrons moderated in passing through the pre-moderator and exiting through a lowermost surface of the pre-moderator, and a plate of moderating material abutting the lowermost surface of the pre-moderator, the plate having an opening therethrough in a shape of a truncated cone with an axis aligning with direction of the ion beam, a depth, a major diameter of at the upper surface of the plate and a minor diameter at the lower surface of the plate, the opening forming a funnel through which neutrons pass. Neutrons enter the funnel and are to exit through the minor diameter of the funnel, providing a neutron beam with a spot size useful for neutron radiography.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: March 23, 2021
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Jay Theodore Cremer, Jr., Charles Kevin Gary, David Lowndes Williams, Allan Xi Chen, Glenn Emerson Jones, Jr., Yao Zong Guan, Randall Scott Urdahl, Adam Nathaniel Amoroso
  • Patent number: 10874881
    Abstract: A treatment system for evaluating boron sources for boron neutron cancer therapy (BNCT) has a substantially square secondary moderator having a central treatment chamber for a subject; and four substantially identical neutron generators positioned around the substantially square secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: December 29, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 10870020
    Abstract: A Boron neutron cancer treatment system has a secondary moderator having a central treatment chamber for a subject, and eight substantially identical neutron generators, each comprising a pre-moderator block. The eight neutron generators are positioned around the secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber, and with the angled sides of the neutron generators fully adjacent.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: December 22, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 10850130
    Abstract: A Boron neutron cancer treatment system has a central treatment chamber for a subject, with six substantially identical neutron generators each having an acceleration chamber, the generators positioned around a secondary moderator with the axis of each acceleration chamber passing through center of the treatment chamber, and with angled sides of the neutron generators fully adjacent.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: December 1, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 10850131
    Abstract: A Boron neutron cancer treatment system has a moderator chamber filled with liquid or granular moderator material except for a central treatment chamber, the moderator chamber having parallel upper and lower surfaces, and a plurality of modular neutron generators fully immersed in the liquid or granular moderator material of the moderator chamber.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: December 1, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Publication number: 20200324145
    Abstract: A Boron neutron cancer treatment system has a secondary moderator having a central treatment chamber for a subject, and eight substantially identical neutron generators, each comprising a pre-moderator block. The eight neutron generators are positioned around the secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber, and with the angled sides of the neutron generators fully adjacent.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 15, 2020
    Applicant: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 10799722
    Abstract: A Boron neutron cancer treatment system has a secondary moderator having a central treatment chamber, and several generators, each comprising a pre-moderator block, an acceleration chamber, a vacuum pump engaging the acceleration chamber at a right angle, a plasma ion chamber opening into the acceleration chamber, a gas source providing deuterium gas to the plasma ion chamber, a microwave energy source ionizing the gas in the plasma ion chamber, a cylindrical primary isolation well extending into the pre-moderator block, a secondary isolation well surrounding the primary isolation well, and a water-cooled titanium target disk at a lower extremity of the isolation well. The neutron generators are positioned around the secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber, and with the angled sides of the neutron generators fully adjacent.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: October 13, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Publication number: 20200316406
    Abstract: A treatment system for evaluating boron sources for boron neutron cancer therapy (BNCT) has a substantially square secondary moderator having a central treatment chamber for a subject; and four substantially identical neutron generators positioned around the substantially square secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 8, 2020
    Applicant: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, JR., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Publication number: 20200316407
    Abstract: A Boron neutron cancer treatment system has a moderator chamber filled with liquid or granular moderator material except for a central treatment chamber, the moderator chamber having parallel upper and lower surfaces, and a plurality of modular neutron generators fully immersed in the liquid or granular moderator material of the moderator chamber.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 8, 2020
    Applicant: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, JR., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Publication number: 20200316405
    Abstract: A Boron neutron cancer treatment system has a central treatment chamber for a subject, with six substantially identical neutron generators each having an acceleration chamber, the generators positioned around a secondary moderator with the axis of each acceleration chamber passing through center of the treatment chamber, and with angled sides of the neutron generators fully adjacent.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 8, 2020
    Applicant: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, JR., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 10737121
    Abstract: A neutron generator has a pre-moderator block of moderating material, an acceleration chamber, a vacuum pump evacuating the acceleration chamber to a moderately high vacuum, a plasma ion chamber opening into the acceleration chamber through an ion extraction iris, a gas source providing deuterium gas to the plasma ion chamber, a microwave energy source ionizing the gas in the plasma ion chamber, a primary and a secondary isolation well extending into the pre-moderator block, a water-cooled titanium target disk positioned at a lower extremity of the primary isolation well, the target disk biased to a substantial negative DC voltage, and electrically grounded metal cladding covering surfaces of the pre-moderator block. Ions extracted through the ion extraction iris are accelerated to bombard the titanium target producing energetic neutrons that pass through and are moderated by the pre-moderator block.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: August 11, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Publication number: 20200246638
    Abstract: A Boron neutron cancer treatment system has a secondary moderator having a central treatment chamber, and several generators, each comprising a pre-moderator block, an acceleration chamber, a vacuum pump engaging the acceleration chamber at a right angle, a plasma ion chamber opening into the acceleration chamber, a gas source providing deuterium gas to the plasma ion chamber, a microwave energy source ionizing the gas in the plasma ion chamber, a cylindrical primary isolation well extending into the pre-moderator block, a secondary isolation well surrounding the primary isolation well, and a water-cooled titanium target disk at a lower extremity of the isolation well. The neutron generators are positioned around the secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber, and with the angled sides of the neutron generators fully adjacent.
    Type: Application
    Filed: February 26, 2020
    Publication date: August 6, 2020
    Applicant: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, JR., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Publication number: 20200069974
    Abstract: A neutron generator has a pre-moderator block of moderating material, an acceleration chamber, a vacuum pump evacuating the acceleration chamber to a moderately high vacuum, a plasma ion chamber opening into the acceleration chamber through an ion extraction iris, a gas source providing deuterium gas to the plasma ion chamber, a microwave energy source ionizing the gas in the plasma ion chamber, a primary and a secondary isolation well extending into the pre-moderator block, a water-cooled titanium target disk positioned at a lower extremity of the primary isolation well, the target disk biased to a substantial negative DC voltage, and electrically grounded metal cladding covering surfaces of the pre-moderator block. Ions extracted through the ion extraction iris are accelerated to bombard the titanium target producing energetic neutrons that pass through and are moderated by the pre-moderator block.
    Type: Application
    Filed: October 24, 2019
    Publication date: March 5, 2020
    Applicant: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, JR., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 8750454
    Abstract: The application discloses systems and methods for X-ray scanning for identifying material composition of an object being scanned. The system includes at least one X-ray source for projecting an X-ray beam on the object, where at least a portion of the projected X-ray beam is transmitted through the object, and an array of detectors for measuring energy spectra of the transmitted X-rays. The measured energy spectra are used to determine atomic number of the object for identifying the material composition of the object. The X-ray scanning system may also have an array of collimated high energy backscattered X-ray detectors for measuring the energy spectrum of X-rays scattered by the object at an angle greater than 90 degrees, where the measured energy spectrum is used in conjunction with the transmission energy spectrum to determine atomic numbers of the object for identifying the material composition of the object.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: June 10, 2014
    Assignee: Rapiscan Systems, Inc.
    Inventors: Tsahi Gozani, Joseph Bendahan, Craig Mathew Brown, Willem Gerhardus Johannes Langeveld, John David Stevenson
  • Publication number: 20110235777
    Abstract: The application discloses systems and methods for X-ray scanning for identifying material composition of an object being scanned. The system includes at least one X-ray source for projecting an X-ray beam on the object, where at least a portion of the projected X-ray beam is transmitted through the object, and an array of detectors for measuring energy spectra of the transmitted X-rays. The measured energy spectra are used to determine atomic number of the object for identifying the material composition of the object. The X-ray scanning system may also have an array of collimated high energy backscattered X-ray detectors for measuring the energy spectrum of X-rays scattered by the object at an angle greater than 90 degrees, where the measured energy spectrum is used in conjunction with the transmission energy spectrum to determine atomic numbers of the object for identifying the material composition of the object.
    Type: Application
    Filed: February 23, 2011
    Publication date: September 29, 2011
    Inventors: Tsahi Gozani, Joseph Bendahan, Craig Mathew Brown, Willem Gerhardus Johannes Langeveld, John David Stevenson
  • Publication number: 20100130598
    Abstract: The present invention relates to methods for inducing or promoting caspase-independent apoptosis in a cell, the method comprising exposing to the cell an effective amount of a compound of formula I as described herein. The invention also relates to methods for treating or preventing diseases and disorders by administering to subjects in need thereof an effective amount of a compound of formula I, wherein the compound induces or promotes caspase-independent apoptosis in at least one cell of the subject.
    Type: Application
    Filed: October 19, 2009
    Publication date: May 27, 2010
    Applicant: Novogen Research Pty Ltd.
    Inventors: David Mathew Brown, Alan James Husband, Gil Mor, Ewan M. Tytler
  • Patent number: 7562300
    Abstract: Automated facilities are provided for uploading media program information through a network connection to an automated encoding system. An encoding request is received from a client which requests that the media program information be encoded in one or more encoding formats to produce publication-ready-media information. Automated facilities also provide ancillary services associated with the publication-ready-media information such as organization control, design control and publication control of the publication-ready-media information.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: July 14, 2009
    Assignee: Loudeye Technologies, Inc.
    Inventors: Martin Tobias, Beverly Kite, Mathews Brown
  • Patent number: 6981050
    Abstract: A method and system for recording and publishing traditional media source programs over a network is disclosed. According to the method, a request for publication of one or more traditional media source programs in one or more encoding formats is received from a network client that is connected to the network. In response to receiving the request, the one or more traditional media source programs are captured from a traditional media source that broadcasts the one or more traditional media source programs at a particular broadcast time. The one or more traditional media source programs are encoded in one or more encoding formats to produce one or more encoded media programs and then published to the network client over the network at a time that is different from the actual broadcast time.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: December 27, 2005
    Assignee: Loudeye Corp.
    Inventors: Martin Tobias, Beverley Kite, Mathews Brown
  • Patent number: 6941802
    Abstract: A vehicle spare tire pressure detection assembly includes a tire support and hoisting unit that performs the function of hoisting and storing a spare tire, and a spare tire pressure detection unit that performs the function of monitoring tire pressure in the spare tire when the spare tire is in a stored state. The tire support and hoisting unit is configured to maintain an initial compression force on a side wall of the spare tire to deflect the side wall of the spare tire. The spare tire pressure detection unit monitors the adjustments made by the tire support and hoisting unit to maintain the initial compression force on the spare tire to determine if the spare tire has lost tire pressure below a predetermined threshold amount. A human detectable signal is produced when the spare tire pressure falls below the predetermined threshold amount.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: September 13, 2005
    Assignee: Nissan Technical Center North America, Inc.
    Inventor: Mathew Brown