Patents by Inventor Mathias D. Viard

Mathias D. Viard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Functionally-interdependent shape switching nucleic acid nanoparticles
    Patent number: 11512313
    Abstract: The description provides a molecular switch comprising at least two nanoparticles, wherein a first nanoparticle comprises DNA and/or RNA oligonucleotides, and a second nanoparticle which is complementary to the first nanoparticle comprises reverse complementary DNA and/or RNA oligonucleotides of the first nanoparticle; wherein the complementary nanoparticles interact under physiological conditions leading to thermodynamically driven conformational changes in the first and second nanoparticles leading to their re-association to release one or more duplexes comprising said DNA and/or RNA oligonucleotides and the reverse complementary DNA and/or RNA oligonucleotides, and wherein the nanoparticles are not rings and have no single stranded toeholds.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: November 29, 2022
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The University of North Carolina at Charlote
    Inventors: Bruce Allen Shapiro, Kirill Andreevich Afonin, Eckart H. U. Bindewald, Mathias D. Viard, Wojciech Kasprzak, Marina A. Dobrovolskaia, Justin R. Halman
  • RNA/DNA HYBRID NANOPARTICLES MODIFIED WITH SINGLE STRANDED RNA TOEHOLDS AND USES THEREOF
    Publication number: 20210162066
    Abstract: The invention discloses the use of single-stranded RNA toeholds of different lengths to promote the re-association of various RNA-DNA hybrids, which results in activation of multiple split functionalities inside human cells. Previously designed RNA/DNA nanoparticles employed single-stranded DNA toeholds to initiate re-association. The use of RNA toeholds is advantageous because of the simpler design rules, the shorter toeholds, and the smaller size of the resulting nanoparticles compared to the same hybrid nanoparticles with single-stranded DNA toeholds. Moreover, the co-transcriptional assemblies result in higher yields for hybrid nanoparticles with ssRNA toeholds.
    Type: Application
    Filed: November 24, 2020
    Publication date: June 3, 2021
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Bruce Allen Shapiro, Kirill Andreevich Afonin, Mathias D. Viard, Eckart H.U. Bindewald, Lorena Parlea
  • FUNCTIONALLY-INTERDEPENDENT SHAPE SWITCHING NUCLEIC ACID NANOPARTICLES
    Publication number: 20200199587
    Abstract: The description provides a molecular switch comprising at least two nanoparticles, wherein a first nanoparticle comprises DNA and/or RNA oligonucleotides, and a second nanoparticle which is complementary to the first nanoparticle comprises reverse complementary DNA and/or RNA oligonucleotides of the first nanoparticle; wherein the complementary nanoparticles interact under physiological conditions leading to thermodynamically driven conformational changes in the first and second nanoparticles leading to their re-association to release one or more duplexes comprising said DNA and/or RNA oligonucleotides and the reverse complementary DNA and/or RNA oligonucleotides, and wherein the nanoparticles are not rings and have no single stranded toeholds.
    Type: Application
    Filed: April 3, 2018
    Publication date: June 25, 2020
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, The University of North Carolina at Charlotte
    Inventors: Bruce Allen Shapiro, Kirill Andreevich Afonin, Eckart H.U. Bindewald, Mathias D. Viard, Wojciech Kasprzak, Marina A. Dobrovolskaia, Justin R. Halman
  • Triggering RNA interference with RNA-DNA and DNA-RNA nanoparticles
    Patent number: 10517890
    Abstract: The instant invention provides RNA nanocubes, DNA nanocubes and R/DNA chimeric nanocubes comprising one or more functionalities. The multifunctional RNA nanocubes are suitable for therapeutic or diagnostic use in a number of diseases or disorders.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: December 31, 2019
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard
  • RNA/DNA HYBRID NANOPARTICLES MODIFIED WITH SINGLE STRANDED RNA TOEHOLDS AND USES THEREOF
    Publication number: 20190192687
    Abstract: The invention discloses the use of single-stranded RNA toeholds of different lengths to promote the re-association of various RNA-DNA hybrids, which results in activation of multiple split functionalities inside human cells. Previously designed RNA/DNA nanoparticles employed single-stranded DNA toeholds to initiate re-association. The use of RNA toeholds is advantageous because of the simpler design rules, the shorter toeholds, and the smaller size of the resulting nanoparticles compared to the same hybrid nanoparticles with single-stranded DNA toeholds. Moreover, the co-transcriptional assemblies result in higher yields for hybrid nanoparticles with ssRNA toeholds.
    Type: Application
    Filed: February 13, 2017
    Publication date: June 27, 2019
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Service
    Inventors: Bruce Allen Shapiro, Kirill Andreevich Afonin, Mathias D. Viard, Eckart H.U. Bindewald, Lorena Parlea
  • Multifunctional RNA nanoparticles and methods of use
    Patent number: 10301621
    Abstract: The instant invention provides RNA nanoparticles and R/DNA chimeric nanoparticles comprising one or more functionalities. The multifunctional RNA nanoparticles are suitable for therapeutic or diagnostic use in a number of diseases or disorders.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: May 28, 2019
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard, Angelica N. Martins
  • TRIGGERING RNA INTERFERENCE WITH RNA-DNA AND DNA-RNA NANOPARTICLES
    Publication number: 20170274000
    Abstract: The instant invention provides RNA nanocubes, DNA nanocubes and R/DNA chimeric nanocubes comprising one or more functionalities. The multifunctional RNA nanocubes are suitable for therapeutic or diagnostic use in a number of diseases or disorders.
    Type: Application
    Filed: May 6, 2015
    Publication date: September 28, 2017
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard
  • MULTIFUNCTIONAL RNA NANOPARTICLES AND METHODS OF USE
    Publication number: 20170121708
    Abstract: The instant invention provides RNA nanoparticles and R/DNA chimeric nanoparticles comprising one or more functionalities. The multifunctional RNA nanoparticles are suitable for therapeutic or diagnostic use in a number of diseases or disorders.
    Type: Application
    Filed: September 17, 2014
    Publication date: May 4, 2017
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard, Angelica N. Martins
  • Auto-recognizing therapeutic RNA/DNA chimeric nanoparticles (NP)
    Patent number: 9631192
    Abstract: Auto-recognizing therapeutic R/DNA chimeric nanoparticles (R/DNA NP) are described that are pairs of DNA/RNA hybrids where the DNA molecules have complementary toehold sequences that promote the re-association of the R/DNA NPs when mixed resulting in the formation of RNA/RNA duplexes that act as siRNAs.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: April 25, 2017
    Assignees: The United States of America, as represented by the Secretary, Department of Health & Human Services, The Regents of the University of California
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard, Eckart H. Bindewald, Luc Jaeger, Arti N. Santhanam
  • AUTO-RECOGNIZING THERAPEUTIC RNA/DNA CHIMERIC NANOPARTICLES (NP)
    Publication number: 20140303237
    Abstract: Auto-recognizing therapeutic R/DNA chimeric nanoparticles (R/DNA NP) are described that are pairs of DNA/RNA hybrids where the DNA molecules have complementary toehold sequences that promote the re-association of the R/DNA NPs when mixed resulting in the formation of RNA/RNA duplexes that act as siRNAs.
    Type: Application
    Filed: November 19, 2012
    Publication date: October 9, 2014
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard, Eckart H. Bindewald