Patents by Inventor Mathias Osswald

Mathias Osswald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of endothelin receptor antogonists for the treatment of tumour diseases
    Publication number: 20050014769
    Abstract: Use of endothelin receptor antagonists for the preparation of a medicament for the treatment of tumour diseases.
    Type: Application
    Filed: October 10, 2002
    Publication date: January 20, 2005
    Inventors: Mathias Osswald, Dieter Dorsch, Werner Mederski, Christiane Amendt, Matthias Grell
  • Benzothia(oxa)diazol derivatives and their use as endothelin-receptor antagonists
    Patent number: 6197800
    Abstract: Novel compounds of the formula I in which R is X is O or S, and R1, R2, R3, R4, R5 and R6 have the meaning indicated in patent claim 1, or a tautomeric ring-closed form, and the (E) isomers and their salts exhibit endothelin receptor-antagonistic properties.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: March 6, 2001
    Assignee: Merck Patent Gesellschaft mi beschraenkter Haftung
    Inventors: Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Maria Christadler, Claus Jochen Schmitges
  • 2,1,3-benzothia(OXA)diazole derivatives having an endothelin receptor antagonistic effect
    Patent number: 6017939
    Abstract: The invention concerns compounds of formula (I),in which R is (i), (ii) or (iii); n is 0, 1 or 2; X means O or S; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have different meanings, or a cyclized tautomeric shape. The invention also concerns the (E) isomers and salts of these compounds which display endothelin receptor antagonistic properties.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: January 25, 2000
    Assignee: Merck Patent Gesellschaft
    Inventors: Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Claus Schmitges, Maria Christadler, Soheila Anzali
  • Endothelin receptor antagonists
    Patent number: 5883090
    Abstract: This invention relates to pyridizinone derivatives of formula I ##STR1## wherein the various substituents are defined in the specification, and salts thereof, which have useful pharmacological properties, in particular endothelin receptor-antagonistic properties. The compounds are thus useful for the treatment of illnesses associated with endothelin activities, such as hypertension, cardiac insufficiency, coronary heart disease, renal, cerebral and myocardial ischaemia, renal insufficiency, cerebral infarct, subarachnoid haemorrhage, arteriosclerosis pulmonary high blood pressure, inflammations, asthma, prostate hyperplasia, endotoxic shock and in complications after the administration of immunosuppressants which produce renal vasoconstriction.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: March 16, 1999
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Claus Jochen Schmitges, Maria Christadler
  • Endothelin receptor antagonists
    Patent number: 5821256
    Abstract: Novel compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and X have the meaning indicated in claim 1, and their salts exhibit endothelin receptor-antagonistic properties.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: October 13, 1998
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Claus J. Schmitges, Maria Christadler
  • Endothelin receptor antagonists
    Patent number: 5731321
    Abstract: Novel compounds of the formula I ##STR1## in which --Y--Z--, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings as stated in the specification, and their salts show endothelin receptor antagonist properties.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: March 24, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Mathias Osswald, Dieter Dorsch, Claudia Wilm, Claus J. Schmitges, Maria Christadler
  • Endothelin receptor antagonists
    Patent number: 5726194
    Abstract: Novel compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, --A.dbd.B--C.dbd.D--, Ar and X have the meaning indicated in claim 1, and their salts show endothelin receptor-antagonistic properties.
    Type: Grant
    Filed: March 18, 1996
    Date of Patent: March 10, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Mathias Osswald, Werner Mederski, Dieter Dorsch, Claudia Wilm, Claus Schmitges, Maria Christadler
  • Endothelin receptor antagonists
    Patent number: 5700807
    Abstract: Novel compounds of the formula ##STR1## in which --Y--Z--, R.sup.1 R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X have the meaning indicated and their salts show endothelin receptor-antagonistic properties.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: December 23, 1997
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Mathias Osswald, Dieter Dorsch, Werner Mederski, Claudia Wilm, Claus J. Schmitges, Maria Christadler
  • Imidazopyridines
    Patent number: 5532276
    Abstract: Novel imidazopyridine derivatives of the formula ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, Ar.sup.1, X and Y are as defined in the specification, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: July 2, 1996
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Mathias Osswald, Norbert Beier, Pierre Schelling, Klaus-Otto Minck, Ingeborg Lues
  • Imidazopyridines
    Patent number: 5476857
    Abstract: Novel imidazopyridine derivatives of formula I: ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: December 19, 1995
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck, Mathias Osswald
  • Imidazopyridines as angiotensin II antagonists
    Patent number: 5438063
    Abstract: Novel imidazopyridine derivatives of formula I ##STR1## wherein ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: August 1, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Mathias Osswald, Werner Mederski, Dieter Dorsch, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
  • Imidazopyridines
    Patent number: 5405964
    Abstract: Novel imidazopyridine derivatives of formula I ##STR1## and X, --Y.dbd.Z--, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 as defined herein, and their salts, exhibit antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: April 11, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Andreas Bathe, Thorsten Hartig, Mathias Osswald, Norbert Beier, Pierre Schelling, Klaus-Otto Minck, Ingeborg Lues
  • Benzimidazole compounds
    Patent number: 5401738
    Abstract: Benzimidazole compounds of the formula I ##STR1## and salts thereof, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and an increased intraocular pressure, as well as disturbances of the central nervous system.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: March 28, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter
    Inventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck, Mathias Osswald
  • Imidazopyridines
    Patent number: 5389642
    Abstract: Novel imidazopyridine derivatives of the formula I ##STR1## in which R is ##STR2## and R.sup.1 to R.sup.4, X and Y are as defined herein, and their salts have antagonistic properties towards angiotensin(II) and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure and also disorders of the central nervous system.
    Type: Grant
    Filed: December 16, 1993
    Date of Patent: February 14, 1995
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Werner Mederski, Mathias Osswald, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck