Abstract: The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. Metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or glyco groups. The sample preparation method can be used for several types of biological samples, including HeLa cells, food, and human cerebrospinal fluid. The proteins are isolated, recovered and ready for analysis by mass spectrometry or other analytical methods allowing detection limits down to the femtomole level. The method and apparatus are valuable tools in the field of protein analysis and diagnostics.

Abstract: The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. Metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or glyco groups. The sample preparation method can be used for several types of biological samples, including HeLa cells, food, and human cerebrospinal fluid. The proteins are isolated, recovered and ready for analysis by mass spectrometry or other analytical methods allowing detection limits down to the femtomole level. The method and apparatus are valuable tools in the field of protein analysis and diagnostics.

Abstract: The present invention relates to a pipette tip which is fitted with a porous organic monolith which is doped with active particles. Due to a unique polymerization method, the extraction tips stay highly permeable which allows sample to pass through the monolithic bed. The extraction tip represents an ideal tool for solid phase extraction, especially for desalting, isolating and purifying biomolecules such as peptides and proteins.

Abstract: The present invention relates to a pipette tip which is fitted with a porous organic monolith which is doped with active particles. Due to a unique polymerization method, the extraction tips stay highly permeable which allows sample to pass through the monolithic bed. The extraction tip represents an ideal tool for solid phase extraction, especially for desalting, isolating and purifying biomolecules such as peptides and proteins.

Abstract: A frame for a vehicle sliding sunroof or tilt-slide sunroof is proposed, comprising at least one single-piece frame base element (22), that is embodied as a plastic injection-molded piece and comprises at least one front frame piece (24) and two side stringers (26, 28) that are directed in the vehicle's longitudinal direction. For formation of a light and stiff frame, the frame base element (22) according to the invention is embodied as a composite component, and provided with at least one profile- or cup-shaped inserted piece (38, 40) that serves as a reinforcing element.

Abstract: A frame for a vehicle sliding sunroof or tilt-slide sunroof is proposed, comprising at least one single-piece frame base element (22), that is embodied as a plastic injection-molded piece and comprises at least one front frame piece (24) and two side stringers (26, 28) that are directed in the vehicle's longitudinal direction. For formation of a light and stiff frame, the frame base element (22) according to the invention is embodied as a composite component, and provided with at least one profile- or cup-shaped inserted piece (38, 40) that serves as a reinforcing element.