Patents by Inventor Mathias Trau
Mathias Trau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7754646Abstract: Highly functionalized, porous organosilica particles and methods of their synthesis are described that employ high amounts of functional silane such as 3-mercaptopropyl trimethoxysilane. Silane particle diameters are controlled from less than 1 ?m to over 100 ?m. The particles have a high surface area due to their advantageous internal structures, which consist of large pores, typically up to 10 ?m that are linked by small channels of typically about 20 nm diameter. Isothiocyanate modified fluorescent dyes can enter and react with thiol groups inside the pores. The invention also provides clear silica shells of controlled thicknesses to protect fluorescent signals and provide an independent parameter for distinguishing particle types based on light scattering off different sized particles. The particles are stable and useful for many purposes, particularly for optical bar coding in combinatorial synthesis of polymers such as nucleic acid, polypeptide, and other synthesized molecules.Type: GrantFiled: July 1, 2002Date of Patent: July 13, 2010Assignee: Nanomics Biosystems Pty LtdInventors: Mathias Trau, Angus Johnston
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Patent number: 7338768Abstract: An assembly of a carrier having one or more reporter beads non-covalently attached thereto which may be used in relation to oligomer libraries. The oligomer libraries may be formed by a combinatorial split-process-recombine procedure. The oligomer library comprises a plurality of molecules comprising a multiplicity of different chemical groups. Each reporter bead has a different marker associated therewith to identify the chemical group attached to the carrier as well as to identify the position in sequence of the chemical group relative to other chemical groups in each molecule of the library. The markers are selected from fluorophores, chromophores, bar codes or radioactive or luminescent labels.Type: GrantFiled: November 12, 1998Date of Patent: March 4, 2008Assignee: Nanomics Biosystems Pty. Ltd.Inventors: Mathias Trau, Darryn Edward Bryant
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Patent number: 7179356Abstract: A process directed to preparing surfactant-polycrystalline inorganic nanostructured materials having designed microscopic patterns. The process includes forming a polycrystalline inorganic substrate having a flat surface and placing in contact with the flat surface of the substrate a surface having a predetermined microscopic pattern. An acidified aqueous reacting solution is then placed in contact with an edge of the surface having the predetermined microscopic pattern. The solution wicks into the microscopic pattern by capillary action. The reacting solution has an effective amount of a silica source and an effective amount of a surfactant to produce a mesoscopic silica film upon contact of the reacting solution with the flat surface of the polycrystalline inorganic substrate and absorption of the surfactant into the surface. Subsequently an electric field is applied tangentially directed to the surface within the microscopic pattern.Type: GrantFiled: April 11, 2003Date of Patent: February 20, 2007Assignee: The Trustees of Princeton UniversityInventors: Ilhan A. Aksay, Mathias Trau, Srinivas Manne, Itaru Honma, George Whitesides
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Publication number: 20040020774Abstract: A process directed to preparing surfactant-polycrystalline inorganic nanostructured materials having designed microscopic patterns. The process includes forming a polycrystalline inorganic substrate having a flat surface and placing in contact with the flat surface of the substrate a surface having a predetermined microscopic pattern. An acidified aqueous reacting solution is then placed in contact with an edge of the surface having the predetermined microscopic pattern. The solution wicks into the microscopic pattern by capillary action. The reacting solution has an effective amount of a silica source and an effective amount of a surfactant to produce a mesoscopic silica film upon contact of the reacting solution with the flat surface of the polycrystalline inorganic substrate and absorption of the surfactant into the surface. Subsequently an electric field is applied tangentially directed to the surface within the microscopic pattern.Type: ApplicationFiled: April 11, 2003Publication date: February 5, 2004Inventors: Ilhan A. Aksay, Mathias Trau, Srinivas Manne, Itaru Honma, George Whitesides
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Publication number: 20030182068Abstract: The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods allow the synthesis of libraries that are sufficiently large to permit complex genomic analyses to be carried out. New methods of using the encoded libraries also are described.Type: ApplicationFiled: October 30, 2002Publication date: September 25, 2003Inventors: Bronwyn J. Battersby, Christopher R. Miller, Mathias Trau, Jeffery C. Way, Angus Johnston
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Publication number: 20030124564Abstract: Highly functionalized, porous organosilica particles and methods of their synthesis are described that employ high amounts of functional silane such as 3-mercaptopropyl trimethoxysilane. Silane particle diameters are controlled from less than 1 &mgr;m to over 100 &mgr;m. The particles have a high surface area due to their advantageous internal structures, which consist of large pores, typically up to 10 &mgr;m that are linked by small channels of typically about 20 nm diameter. Isothiocyanate modified fluorescent dyes can enter and react with thiol groups inside the pores. The invention also provides clear silica shells of controlled thicknesses to protect fluorescent signals and provide an independent parameter for distinguishing particle types based on light scattering off different sized particles. The particles are stable and useful for many purposes, particularly for optical bar coding in combinatorial synthesis of polymers such as nucleic acid, polypeptide, and other synthesized molecules.Type: ApplicationFiled: July 1, 2002Publication date: July 3, 2003Inventors: Mathias Trau, Angus Johnston
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Patent number: 6547940Abstract: A process directed to preparing surfactant-polycrystalline inorganic nanostructured materials having designed microscopic patterns. The process includes forming a polycrystalline inorganic substrate having a flat surface and placing in contact with the flat surface of the substrate a surface having a predetermined microscopic pattern. An acidified aqueous reacting solution is then placed in contact with an edge of the surface having the predetermined microscopic pattern. The solution wicks into the microscopic pattern by capillary action. The reacting solution has an effective amount of a silica source and an effective amount of a surfactant to produce a mesoscopic silica film upon contact of the reacting solution with the flat surface of the polycrystalline inorganic substrate and absorption of the surfactant into the surface. Subsequently an electric field is applied tangentially directed to the surface within the microscopic pattern.Type: GrantFiled: May 7, 2001Date of Patent: April 15, 2003Assignee: The Trustees of Princeton UniversityInventors: Ilhan A. Aksay, Mathias Trau, Srinivas Manne, Itaru Honma, George Whitesides
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Publication number: 20010023024Abstract: A process directed to preparing surfactant-polycrystalline inorganic nanostructured materials having designed microscopic patterns. The process includes forming a polycrystalline inorganic substrate having a flat surface and placing in contact with the flat surface of the substrate a surface having a predetermined microscopic pattern. An acidified aqueous reacting solution is then placed in contact with an edge of the surface having the predetermined microscopic pattern. The solution wicks into the microscopic pattern by capillary action. The reacting solution has an effective amount of a silica source and an effective amount of a surfactant to produce a mesoscopic silica film upon contact of the reacting solution with the flat surface of the polycrystalline inorganic substrate and absorption of the surfactant into the surface. Subsequently an electric field is applied tangentially directed to the surface within the microscopic pattern.Type: ApplicationFiled: May 7, 2001Publication date: September 20, 2001Inventors: Ilhan A. Aksay, Mathias Trau, Srinivas Manne, Itaru Honma, George Whitesides
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Patent number: 6228248Abstract: A process directed to preparing surfactant-polycrystalline inorganic nanostructured materials having designed microscopic patterns. The process includes forming a polycrystalline inorganic substrate having a flat surface and placing in contact with the flat surface of the substrate a surface having a predetermined microscopic pattern. An acidified aqueous reacting solution is then placed in contact with an edge of the surface having the predetermined microscopic pattern. The solution wicks into the microscopic pattern by capillary action. The reacting solution has an effective amount of a silica source and an effective amount of a surfactant to produce a mesoscopic silica film upon contact of the reacting solution with the flat surface of the polycrystalline inorganic substrate and absorption of the surfactant into the surface. Subsequently an electric field is applied tangentially directed to the surface within the microscopic pattern.Type: GrantFiled: April 14, 1999Date of Patent: May 8, 2001Assignee: The Trustees of Princeton UniversityInventors: Ilhan A. Aksay, Mathias Trau, Srinivas Manne, Itaru Honma, George Whitesides
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Patent number: 6033547Abstract: A method apparatus is provided for electrophoretically depositing particles onto an electrode, and electrohydrodynamically assembling the particles into crystalline structures. Specifically, the present method and apparatus creates a current flowing through a solution to cause identically charged electrophoretically deposited colloidal particles to attract each other over very large distances (<5 particle diameters) on the surface of electrodes to form two-dimensional colloidal crystals. The attractive force can be created with both DC and AC fields and can modulated by adjusting either the field strength or frequency of the current. Modulating this "lateral attraction" between the particles causes the reversible formation of two-dimensional fluid and crystalline colloidal states on the electrode surface. Further manipulation allows for the formation of two or three-dimensional colloidal crystals, as well as more complex "designed" structures.Type: GrantFiled: January 4, 1999Date of Patent: March 7, 2000Assignee: The Trustees of Princeton UniversityInventors: Mathias Trau, Ilhan A. Aksay, Dudley A. Saville
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Patent number: 6004444Abstract: A process directed to preparing surfactant-polycrystalline inorganic nanostructured materials having designed microscopic patterns. The process includes forming a polycrystalline inorganic substrate having a flat surface and placing in contact with the flat surface of the substrate a surface having a predetermined microscopic pattern. An acidified aqueous reacting solution is then placed in contact with an edge of the surface having the predetermined microscopic pattern. The solution wicks into the microscopic pattern by capillary action. The reacting solution has an effective amount of a silica source and an effective amount of a surfactant to produce a mesoscopic silica film upon contact of the reacting solution with the flat surface of the polycrystalline inorganic substrate and absorption of the surfactant into the surface. Subsequently an electric field is applied tangentially directed to the surface within the microscopic pattern.Type: GrantFiled: November 5, 1997Date of Patent: December 21, 1999Assignee: The Trustees of Princeton UniversityInventors: Ilhan A. Aksay, Mathias Trau, Srinivas Manne, Itaru Honma, George Whitesides
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Patent number: 5855753Abstract: A method apparatus is provided for electrophoretically depositing particles onto an electrode, and electrohydrodynamically assembling the particles into crystalline structures. Specifically, the present method and apparatus creates a current flowing through a solution to cause identically charged electrophoretically deposited colloidal particles to attract each other over very large distances (<5 particle diameters) on the surface of electrodes to form two-dimensional colloidal crystals. The attractive force can be created with both DC and AC fields and can modulated by adjusting either the field strength or frequency of the current. Modulating this "lateral attraction" between the particles causes the reversible formation of two-dimensional fluid and crystalline colloidal states on the electrode surface. Further manipulation allows for the formation of two or three-dimensional colloidal crystals, as well as more complex "designed" structures.Type: GrantFiled: November 26, 1996Date of Patent: January 5, 1999Assignee: The Trustees of Princeton UniversityInventors: Mathias Trau, Ilhan A. Aksay, Dudley A. Saville