Patents by Inventor Mathias Viard

Mathias Viard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Binary lipid bilayer-containing vesicles comprising embedded cytotoxic agents and methods of making and using the same
    Patent number: 12178907
    Abstract: Embodiments of vesicles comprising embedded cytotoxic agents are disclosed, as well as methods of making and using the vesicles. Pharmaceutical compositions including the vesicles also are disclosed. The vesicles include a binary lipid bilayer surrounding a cavity, wherein the vesicle binary lipid bilayer includes (i) a non-bilayer forming lipid (or combination of non-bilayer forming lipids) and a PEGylated lipid; and (i) a cytotoxic agent embedded within the vesicle wall.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: December 31, 2024
    Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Anu Puri, Mathias Viard
  • BINARY LIPID BILAYER-CONTAINING VESICLES COMPRISING EMBEDDED CYTOTOXIC AGENTS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20210236424
    Abstract: Embodiments of vesicles comprising embedded cytotoxic agents are disclosed, as well as methods of making and using the vesicles. Pharmaceutical compositions including the vesicles also are disclosed. The vesicles include a binary lipid bilayer surrounding a cavity, wherein the vesicle binary lipid bilayer includes (i) a non-bilayer forming lipid (or combination of non-bilayer forming lipids) and a PEGylated lipid; and (i) a cytotoxic agent embedded within the vesicle wall.
    Type: Application
    Filed: July 11, 2019
    Publication date: August 5, 2021
    Applicant: The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Anu Puri, Mathias Viard
  • Photoactivatable lipid-based nanoparticles as vehicles for dual agent delivery
    Patent number: 10117942
    Abstract: Embodiments of photoactivatable, lipid-based nanoparticles are disclosed, as well as methods of making and using the nanoparticles. Pharmaceutical compositions including the nanoparticles also are disclosed. The lipid-based nanoparticles include a vesicle wall surrounding a cavity, wherein the vesicle wall includes (i) a lipid bilayer comprising 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC), dipalmitoylphosphatidylcholine (DPPC), and (ii) 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) within the lipid bilayer. The nanoparticles may further include an agent within the cavity.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: November 6, 2018
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Baylor College of Medicine
    Inventors: Anu Puri, Robert P. Blumenthal, Amit Joshi, Darayash B. Tata, Mathias Viard
  • Cellular and viral inactivation
    Patent number: 8613934
    Abstract: The invention involves inactivation of viral populations by treating the viral populations with a compound to crosslink proteins in the viral membrane, UV irradiation and further inactivation of the viruses using detergent(s). According to the invention, this method preserves the native structure of viral epitopes so that the inactivated viral preparations can be used in immunological compositions that will inhibit and/or prevent viral infection when administered to an animal.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: December 24, 2013
    Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Yossef Raviv, Julie M. Belanger, Mathias Viard, Robert Blumenthal, Julian W. Bess, Jr.
  • Inactivated influenza virus compositions
    Patent number: 8278083
    Abstract: The invention provides compositions of inactivated influenza virus that can be used as vaccines and immunological compositions useful for inhibiting, preventing and treating influenza.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: October 2, 2012
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, University of Georgia Research Foundation, Inc.
    Inventors: Yossef Raviv, Mathias Viard, Robert Blumenthal, Robert J. Hogan, Stephen Mark Tompkins
  • Cellular and viral inactivation
    Patent number: 8268602
    Abstract: The invention provides compositions of inactivated viruses, bacteria, fungi, parasites and tumor cells that can be used as vaccines. Methods for making such inactivated viruses, bacteria, fungi, parasites and tumor cells are also provided.
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: September 18, 2012
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Yossef Raviv, Mathias Viard, Robert Blumenthal
  • Cellular And Viral Inactivation
    Publication number: 20110038890
    Abstract: The invention involves inactivation of viral populations by treating the viral populations with a compound to crosslink proteins in the viral membrane, UV irradiation and further inactivation of the viruses using detergent(s). According to the invention, this method preserves the native structure of viral epitopes so that the inactivated viral preparations can be used in immunological compositions that will inhibit and/or prevent viral infection when administered to an animal.
    Type: Application
    Filed: July 30, 2010
    Publication date: February 17, 2011
    Inventors: Yossef Raviv, Julie M. Belanger, Mathias Viard, Robert Blumenthal, Julian W. Bess, JR.
  • Cellular and viral inactivation
    Publication number: 20100226938
    Abstract: The invention provides compositions of inactivated viruses, bacteria, fungi, parasites and tumor cells that can be used as vaccines. Methods for making such inactivated viruses, bacteria, fungi, parasites and tumor cells are also provided.
    Type: Application
    Filed: September 21, 2006
    Publication date: September 9, 2010
    Inventors: Yossef Raviv, Mathias Viard, Robert Blumenthal
  • Inactivated Influenza Virus Compositions
    Publication number: 20090297558
    Abstract: The invention provides compositions of inactivated influenza virus that can be used as vaccines and immunological compositions useful for inhibiting, preventing and treating influenza.
    Type: Application
    Filed: March 23, 2007
    Publication date: December 3, 2009
    Inventors: Yossef Raviv, Mathias Viard, Robert Blumenthal, Robert J. Hogan, Stephen Mark Tompkins