Abstract: Provided herein are methods for treating uveal melanoma in a subject in need thereof, and methods of detecting high-risk uveal melanoma in a subject, the subject having been selected by a method comprising, or alternatively consisting essentially of, or yet further consisting of detection of high methyl ati on levels at one or more of: BAP-1, CCNG2 and/or FKBP14 and/or measuring the mRNA expression of JARID2 and TMEM173 and determining ratio of mRNA expression JARID2 to TMEM173 in a sample isolated from the subject. Further provided herein are methods of determining prognosis of a subject having uveal melanoma, wherein high methylation levels and/or the ratio of mRNA expression JARID2 to TMEM173 of less than about 1 indicate a decreased probability and/or duration of survival and low methylation levels and/or the ratio of mRNA expression JARID2 to TMEM173 of greater than about 1 indicate an increased probability and/or duration of survival.