Patents by Inventor Mathieu Desclaux

Mathieu Desclaux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODELS OF TAUOPATHY
    Publication number: 20240076613
    Abstract: BANF1, PPP2CA, and ANKLE2 were identified as genes that promote tau aggregation when disrupted. Improved tauopathy models such as cells, tissues, or animals having mutations in or inhibition of expression of BANF1 and/or PPP2CA and/or ANKLE2 are provided. Methods of using such improved tauopathy models for assessing therapeutic candidates for the treatment of a tauopathy, methods of making the improved tauopathy models, and methods of accelerating or exacerbating tau aggregation in a tauopathy model are also provided.
    Type: Application
    Filed: November 6, 2023
    Publication date: March 7, 2024
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Marine Prissette, Matthew Koss, Mathieu Desclaux, John McWhirter, Arijit Bhowmick, David Frendewey, Brian Zambrowicz, Claudia Racioppi
  • Models of tauopathy
    Patent number: 11845957
    Abstract: BANF1, PPP2CA, and ANKLE2 were identified as genes that promote tau aggregation when disrupted. Improved tauopathy models such as cells, tissues, or animals having mutations in or inhibition of expression of BANF1 and/or PPP2CA and/or ANKLE2 are provided. Methods of using such improved tauopathy models for assessing therapeutic candidates for the treatment of a tauopathy, methods of making the improved tauopathy models, and methods of accelerating or exacerbating tau aggregation in a tauopathy model are also provided.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: December 19, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Marine Prissette, Matthew Koss, Mathieu Desclaux, John McWhirter, Arijit Bhowmick, David Frendewey, Brian Zambrowicz, Claudia Racioppi
  • MODELS OF TAUOPATHY
    Publication number: 20210009949
    Abstract: BANF1, PPP2CA, and ANKLE2 were identified as genes that promote tau aggregation when disrupted. Improved tauopathy models such as cells, tissues, or animals having mutations in or inhibition of expression of BANF1 and/or PPP2CA and/or ANKLE2 are provided. Methods of using such improved tauopathy models for assessing therapeutic candidates for the treatment of a tauopathy, methods of making the improved tauopathy models, and methods of accelerating or exacerbating tau aggregation in a tauopathy model are also provided.
    Type: Application
    Filed: June 12, 2020
    Publication date: January 14, 2021
    Inventors: Marine Prissette, Matthew Koss, Mathieu Desclaux, John McWhirter, Arijit Bhowmick, David Frendewey, Brian Zambrowicz