Patents by Inventor Mathieu GALIBERT

Mathieu GALIBERT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KISS1R receptor agonist compounds and use thereof for inducing ovulation in mammals
    Patent number: 9884891
    Abstract: A KISS1R agonist peptide compound capable of inducing ovulation in a female mammal is provided. The compound is a pseudopeptide having the C-terminal sequence: -Xaa?[Tz]Xaa2-Xaa3-Xaa4-NH2 (SEQ ID NO: 3), where ?[Tz] represents a 1,4-disubstituted 1,2,3-triazole group replacing the peptide bond between the Xaa1 residue and the Xaa2 residue, Xaa1 is Gly or Ala, Xaa2 is Leu or an aliphatic ?-aminoacyl analog residue, Xaa3 is Arg, Arg(Me) or a positively charged ?-aminoacyl analog residue, and Xaa4 is Tyr, Phe, Trp or an ?-aminoacyl analog residue such as aryl alanine; or an analog of the pseudopeptide in which the amide peptide bond between Xaa2 and Xaa3 and/or between Xaa3 and Xaa4 is replaced with an isosteric bond, or a salt thereof.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: February 6, 2018
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Massimiliano Beltramo, Vincent Aucagne, Alain Caraty, Agnes Delmas, Mathieu Galibert
  • KISS1R RECEPTOR AGONIST COMPOUNDS AND USE THEREOF FOR INDUCING OVULATION IN MAMMALS
    Publication number: 20150361138
    Abstract: A KISS1R agonist peptide compound capable of inducing ovulation in a female mammal is provided. The compound is a pseudopeptide having the C-terminal sequence: -Xaa?[Tz]Xaa2-Xaa3-Xaa4-NH2 (SEQ ID NO: 3), where ?[Tz] represents a 1,4-disubstituted 1,2,3-triazole group replacing the peptide bond between the Xaa1 residue and the Xaa2 residue, Xaa1 is Gly or Ala, Xaa2 is Leu or an aliphatic ?-aminoacyl analogue residue, Xaa3 is Arg, Arg(Me) or a positively charged ?-aminoacyl analogue residue, and Xaa4 is Tyr, Phe, Trp or an ?-aminoacyl analogue residue such as aryl alanine; or an analogue of the pseudopeptide in which the amide peptide bond between Xaa2 and Xaa3 and/or between Xaa3 and Xaa4 is replaced with an isosteric bond, or a salt thereof.
    Type: Application
    Filed: January 31, 2014
    Publication date: December 17, 2015
    Inventors: Massimiliano BELTRAMO, Vincent AUCAGNE, Alain CARATY, Agnes DELMAS, Mathieu GALIBERT