Abstract: The continuous monitoring of electroencephalogram (EEG) and electrocardiogram (ECG) is crucial for detecting the degree of inflammation in a patient in a hospital setting, especially in the intensive care unit. In particular, the heart rate variability is known to correlate with the degree of inflammation. When the inflammation accelerates, this can lead to septic shock of the patient and subsequently multi-organ failure. Therefore, there is a need for a device that monitors the degree of sepsis of the patient. The present invention discloses a method and apparatus for monitoring the EEG and the ECG, and a method combining information from the EEG and the ECG which together with features extracted from the EEG and the ECG are the inputs to a prediction model such as an adaptive neuro fuzzy inference system the output of which is an index of sepsis.

Abstract: The present invention disclosed a device and method for assessing in real time the hypnotic and analgesic effect in a subject during wakefulness, sedation and general anaesthesia via drug interactions and physiological signals. In a preferred embodiment of the present invention, the analgesic and hypnotic effect of drug(s) infused in a subject could be accurately assessed in real time through the device and method disclosed in the present invention, comprising steps of receiving data from electroencephalography (EEG) device, receiving data from brain impedance tomography device, obtaining pharmacodynamic and pharmacokinetic parameters of drug(s) infused in the subject, defining initial indices of consciousness and nociception as a function of said EEG and brain impedance tomography data, and generating output of final indices of consciousness and nociception in real time from processing input of EEG, brain tomography and drug interaction data using established mathematical manipulation.

Abstract: The present invention disclosed a device and method for assessing in real time the hypnotic and analgesic effect in a subject during wakefulness, sedation and general anaesthesia via drug interactions and physiological signals. In a preferred embodiment of the present invention, the analgesic and hypnotic effect of drug(s) infused in a subject could be accurately assessed in real time through the device and method disclosed in the present invention, comprising steps of receiving data from electroencephalography (EEG) device, receiving data from brain impedance tomography device, obtaining pharmacodynamic and pharmacokinetic parameters of drug(s) infused in the subject, defining initial indices of consciousness and nociception as a function of said EEG and brain impedance tomography data, and generating output of final indices of consciousness and nociception in real time from processing input of EEG, brain tomography and drug interaction data using established mathematical manipulation.