Abstract: A squeeze detection system includes an elongated body extending along a longitudinal direction. The elongated body has a handle. A sensor assembly is positioned within the elongated body proximate the handle. The sensor assembly includes conductive target mounted to the elongated body. An inductive sensor is also mounted to the elongated body. A gap is defined between a coil of the inductive sensor and a target surface of the conductive target. The conductive target and the inductive sensor are mounted to the elongated body such that a size of the gap is changeable in order to detect a squeeze in either a first direction or a second direction within a plane that is perpendicular to the longitudinal direction at the handle of the elongated body. The first and second directions are perpendicular.

Abstract: A computer-implemented method includes receiving a series of measurements of distances generated, from a plurality of different positions each time, by a detection system operating by: transmitting a wave; receiving waves reflected by the environment; determining the distances by calculating differences between the wave transmission time and the time of reception of the reflected waves; generating, based on the series of distance measurements, a synthetic image representing the distances from the environment relative to a reference position; for each focal distance of a plurality of focal distances: generating, from the series of distance measurements or the synthetic image, a synthetic image that is focused at the focal distance, by applying compensation for penumbra effects; and detecting the presence of an object in the focused synthetic image.

Abstract: The present invention provides composition kits and methods for treating cancer in a human by immunotherapy using successive doses of CAR-T cells with no or reduced anamnestic immune reaction in one individual (P).

Abstract: The present invention pertains to engineered immune cells, method for their preparation and their use as medicament, particularly for immunotherapy. The engineered immune cells of the present invention are characterized in that at least one gene selected from a gene encoding GCN2 and a gene encoding PRDM1 is inactivated or repressed. Such modified Immune cells are resistant to an arginine and/or tryptophan depleted microenvironment caused by, e.g., tumor cells, which makes the immune cells of the invention particularly suitable for immunotherapy. The invention opens the way to standard and affordable adoptive immunotherapy strategies using immune cells for treating different types of malignancies.

Abstract: The present invention provides composition kits and methods for treating cancer in a human by immunotherapy using successive doses of CAR-T cells with no or reduced anamnestic immune reaction in one individual (P).

Abstract: An aeronautical thruster having a longitudinal axis and having a hub and at least two annular rows of unducted blades including an upstream annular row and a downstream annular row which are spaced apart from one another along the longitudinal axis, the upstream annular row being rotatable around the longitudinal axis, and the downstream annular row comprising a series of blades including a first blade and a second blade each extending in a radial direction from the hub to define a radial dimension between the hub and a radially outer end of the corresponding blade, wherein the radial dimension of the first blade is greater than the radial dimension of the second blade.

Abstract: An airflow profile structure having a leading and/or trailing edge profiled with a serrated profile having a succession of teeth and depressions. Along the leading and/or trailing edge, from a first location to a second location, the teeth of the serrated profile are individually inclined towards the second location.

Abstract: Systems and methods are provided in which physical objects in the ambient environment can function as user interface implements in an augmented reality environment. A physical object detected within a field of view of a camera of a computing device may be designated as a user interface implement in response to a user command. User interfaces may be attached to the designated physical object, to provide a tangible user interface implement for user interaction with the augmented reality environment.

Abstract: An airflow profiled structure having a profiled leading edge. The profiled leading edge having, along a leading edge line, a serrated profile line with a succession of teeth and depressions. The airflow profiled structure also includes a porous acoustically absorbent region located towards the bottom of the depressions.

Abstract: A variable pitch bladed disc including a plurality of blades, each being of variable pitch about a blade axis of rotation and having a root, the plurality of blades including at least one first blade and at least one second blade, a plurality of rotor connecting shafts, each shaft having a root and a tip, the root of each blade being mounted on the tip of a corresponding rotor connecting shaft via a pivot so as to allow each blade to be rotated about the blade axis of rotation, the first blade having a first rotation axis inclination such that the rotation axis thereof is inclined in a fixed manner with respect to a radial axis passing through the root of the corresponding shaft, and the second blade has a second rotation axis inclination different from the first rotation axis inclination.

Abstract: Systems and methods are provided in which physical objects in the ambient environment can function as user interface implements in an augmented reality environment. A physical object detected within a field of view of a camera of a computing device may be designated as a user interface implement in response to a user command. User interfaces may be attached to the designated physical object, to provide a tangible user interface implement for user interaction with the augmented reality environment.

Abstract: A turbomachine includes a rotor and a stator, the stator having a plurality of profiled structures, each profiled structure being elongated in a direction of elongation in which the profiled structure has a length exposed to an airflow, and having a leading edge and/or a trailing edge, at least one of which is profiled and has, in said direction of elongation, serrations defined by a succession of peaks and troughs and having a geometric pattern transformed, over at least a part of said length exposed to the airflow, by successive scaling, via multiplicative factors, in the direction of elongation and/or transverse to the direction of elongation. The geometric pattern, as defined with reference to a radial distribution of the integral scale of the turbulence, evolves in a non-periodic manner.

Abstract: An airflow profile structure having a leading and/or trailing edge profiled with a serrated profile having a succession of teeth and depressions. Along the leading and/or trailing edge, from a first location to a second location, the teeth of the serrated profile are individually inclined towards the second location.

Abstract: A profiled structure for an aircraft or turbomachine is elongated in a direction in which the structure has a length exposed to an airflow and includes serrations defined by successive teeth and depressions. The serrations may be transverse to a leading edge and/or a trailing edge of the profiled structure and in the direction of elongation. Along the profiled leading edge and/or profiled trailing edge, the successive teeth and depressions may extend only over a part of the length exposed to the flow. The amplitude and/or spacing of the teeth may vary monotonically except for the few teeth nearest each end of the part, with a remaining part of the length being smooth.

Abstract: A turbomachine includes a rotor and a stator, the stator having a plurality of profiled structures, each profiled structure being elongated in a direction of elongation in which the profiled structure has a length exposed to an airflow, and having a leading edge and/or a trailing edge, at least one of which is profiled and has, in said direction of elongation, serrations defined by a succession of peaks and troughs and having a geometric pattern transformed, over at least a part of said length exposed to the airflow, by successive scaling, via multiplicative factors, in the direction of elongation and/or transverse to the direction of elongation. The geometric pattern, as defined with reference to a radial distribution of the integral scale of the turbulence, evolves in a non-periodic manner.

Abstract: An airflow profile structure having a leading and/or trailing edge profiled with a serrated profile. The serrated profile has a succession of teeth and depressions, characterized in that, along the leading and/or trailing edge, from a first location to a second location, the teeth of the serrated profile are individually inclined towards the second location.

Abstract: A variable-pitch bladed disc including a plurality of blades, each at a variable pitch in relation to a rotation axis of the blade and each having a root, the plurality of blades including at least one first blade and at least one second blade, a plurality of rotor connecting shafts, each having a root and a tip, each root being mounted at the tip of a corresponding rotor connecting shaft by way of a pivot so as to allow each blade to rotate about the blade rotation axis, the first blade having a first blade inclination, such that the first blade is inclined in a fixed manner with respect to the blade rotation axis of the first blade, and the second blade having a second blade inclination different from the first blade inclination.

Abstract: The invention relates to a profiled structure elongated in a direction in which the structure has a length exposed to an airflow and transversely to which the structure has a leading edge and/or a trailing edge, at least one of which is profiled and has, along said direction of elongation, geometric serration patterns defined by a succession of peaks and troughs. Along the profiled leading edge and/or trailing edge, the serration patterns have a geometric pattern that is repeated in the direction of elongation, the shape of which is stretched and/or contracted transversely to the direction of elongation and/or in the direction of elongation.

Abstract: A front fan turbomachine includes an annular separating wall having a slat for separating an air flow between a primary flow and a secondary flow, the slat having a leading edge; inlet guide vanes (IGV) for guiding the primary flow and outlet guide vanes (OGV) blades for guiding the secondary flow. The leading edge of the slat has a serrated profile having a succession of teeth and depressions.

Abstract: The present invention provides composition kits and methods for treating cancer in a human by immunotherapy using successive doses of CAR-T cells with no or reduced anamnestic immune reaction in one individual (P).