Abstract: Disposable cover for a mechanical resection device. At least one example is a surgical system including: a bottom cover and a motor drive unit (MDU). The bottom cover may include: a lower trough defined by an inside surface of the bottom cover; a cover receptacle; a stationary hub rigidly coupled to the cover receptacle, the stationary hub protruding into the lower trough; and a transmission shaft defining proximal coupler, a distal coupler, and a longitudinal central axis, the transmission shaft extends through the stationary hub such that the distal coupler is in operational relationship to the cover receptacle. The MDU, disposed within the lower trough, may define a motor with a drive shaft, a handpiece receptacle on an end of the MDU, and a handpiece coupler in operational relationship to the handpiece receptacle, the handpiece receptacle telescoped over the stationary hub, and the handpiece coupler coupled to the proximal coupler.