Patents by Inventor Mathilde H. Lerche

Mathilde H. Lerche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hyperpolarized 1-13C-1,1-bis(acetoxy(methyl))-2,2?-cyclopropane as metabolic marker for MR
    Patent number: 10583209
    Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: March 10, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Mathilde H. Lerche, Pernille Rose Jensen, Magnus Karlsson, Roberta Napolitano, Claudia Cabella, Luigi Miragoli, Sonia Colombo Serra, Fabio Tedoldi
  • HYPERPOLARIZED 1-13C-1,1-BIS(ACETOXY(METHYL))-2,2'-CYCLOPROPANE AS METABOLIC MARKER FOR MR
    Publication number: 20190275180
    Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.
    Type: Application
    Filed: March 25, 2019
    Publication date: September 12, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Mathilde H. LERCHE, Pernille Rose JENSEN, Magnus KARLSSON, Roberta NAPOLITANO, Claudia CABELLA, Luigi MIRAGOLI, Sonia COLOMBO SERRA, Fabio TEDOLDI
  • Hyperpolarized amino acids
    Patent number: 9925280
    Abstract: Method for manufacturing a hyperpolarized amino acid, in particular glutamine, which substantially limits the formation of by-products, with respect to conventional aqueous preparations of sodium hydroxide with amino acids. The amino acid is in particular admixed with the hydroxide in the substantial absence of water and the dry mixture is dissolved in an anhydrous solvent in the presence of a polarizing agent. The obtained mixture is then subjected to a DNP process and can be used in metabolic MR imaging.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: March 27, 2018
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche
  • Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
    Patent number: 9693828
    Abstract: The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: July 4, 2017
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi, Massimo Visigalli
  • Process for preparing hyperpolarized substrates and method for MRI
    Patent number: 9694090
    Abstract: The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: July 4, 2017
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Giovanni Battista Giovenzana, Fabio Tedoldi, Alessandro Maiocchi, Fulvio Uggeri, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Massimo Visigalli, Marco Crosetti, Luisa Poggi
  • Process for the preparation of hyperpolarized derivatives for use in MRI analysis
    Patent number: 9511154
    Abstract: The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: December 6, 2016
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Giovanni Battista Giovenzana, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi
  • HYPERPOLARIZED 1-13C-1,1-BIS(ACETOXY(METHYL))-2,2'-CYCLOPROPANE AS METABOLIC MARKER FOR MR
    Publication number: 20160296645
    Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.
    Type: Application
    Filed: June 30, 2014
    Publication date: October 13, 2016
    Applicant: BRACCO IMAGING S.P.A
    Inventors: Mathilde H. Lerche, Pernille Rose JENSEN, Magnus KARLSSON, Roberta NAPOLITANO, Claudia CABELLA, Luigi MIRAGOLI, Sonia COLOMBO SERRA, Fabio TEDOLDI
  • Triarylmethyl radicals
    Patent number: 9381257
    Abstract: New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl (“trityl”) radicals which can be used as polarizing agents for polarizing a molecule in the DNP process.
    Type: Grant
    Filed: July 4, 2013
    Date of Patent: July 5, 2016
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Roberta Napolitano, Fabio Tedoldi, Massimo Visigalli
  • HYPERPOLARIZED 2-OXOGLUTARATE AS METABOLIC AGENT IN MR
    Publication number: 20150273086
    Abstract: Hyperpolarized 1-13C-2-oxoglutarate as contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said 1-13C-2-oxoglutarate, signals of 1-13C-glutamate are detected. More in particular, different MR signals from 13C nuclei are detected and compared, said comparison being useful to determine a difference between tumor and non-tumor tissues, to determine the aggressiveness of a tumor or the efficacy of an anti-tumor therapy.
    Type: Application
    Filed: October 24, 2013
    Publication date: October 1, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Claudia Cabella, Lara Caminiti, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Luigi Miragoli, Luisa Poggi, Fabio Tedoldi, Luca Venturi
  • TRIARYLMETHYL RADICALS
    Publication number: 20150151009
    Abstract: New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl (“trityl”) radicals which can be used as polarizing agents for polarizing a molecule in the DNP process.
    Type: Application
    Filed: July 4, 2013
    Publication date: June 4, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Roberta Napolitano, Fabio Tedoldi, Massimo Visigalli
  • HYPERPOLARIZED AMINO ACIDS
    Publication number: 20150118159
    Abstract: Method for manufacturing a hyperpolarized amino acid, in particular glutamine, which substantially limits the formation of by-products, with respect to conventional aqueous preparations of sodium hydroxide with amino acids. The amino acid is in particular admixed with the hydroxide in the substantial absence of water and the dry mixture is dissolved in an anhydrous solvent in the presence of a polarizing agent. The obtained mixture is then subjected to a DNP process and can be used in metabolic MR imaging.
    Type: Application
    Filed: March 28, 2013
    Publication date: April 30, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche
  • Composition Comprising Acetic Anhydride And A Gadolinium Complex, And Method For The Use In Hyperpolarisation In MRI Analysis
    Publication number: 20140343402
    Abstract: The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.
    Type: Application
    Filed: December 3, 2012
    Publication date: November 20, 2014
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi, Massimo Visigalli
  • COMPOSITION AND METHOD FOR GENERATING A METABOLIC PROFILE USING 13C-MR DETECTION
    Publication number: 20140328766
    Abstract: The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fumarate and imaging media comprising hyperpolarised 13C-fumarate for use in said method.
    Type: Application
    Filed: July 16, 2014
    Publication date: November 6, 2014
    Inventors: Anna Gisselsson, Georg Hansson, Sven Mansson, Rene In't Zandt, Magnus Karlsson, Pernille R. Jensen, Mathilde H. Lerche
  • Process For The Preparation Of Hyperpolarized Derivatives For Use In MRI Analysis
    Publication number: 20140257085
    Abstract: The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.
    Type: Application
    Filed: October 11, 2012
    Publication date: September 11, 2014
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Sonia Colombo Serra, Giovanni Battista Giovenzana, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi
  • Process For Preparing Hyperpolarized Substrates And Method For MRI
    Publication number: 20130096420
    Abstract: The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.
    Type: Application
    Filed: April 8, 2011
    Publication date: April 18, 2013
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvio Aime, Giovanni Battista Giovenzana, Fabio Tedoldi, Alessandro Maiocchi, Fulvio Uggeri, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Massimo Visigalli, Marco Crosetti, Luisa Poggi
  • METHOD AND IMAGING MEDIUM FOR USE IN THE METHOD
    Publication number: 20110243855
    Abstract: The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C acetate and to an imaging medium comprising hyperpolarised 13C-acetate.
    Type: Application
    Filed: August 26, 2008
    Publication date: October 6, 2011
    Inventors: Anna Gisselsson, Georg Hansson, Sven Mansson, Rene In't Zandt, Magnus Karlsson, Pernille R. Jensen, Mathilde H. Lerche
  • MR IMAGING AGENT, IMAGING MEDIUM AND METHODS OF IMAGING WHEREIN SUCH AN IMAGING MEDIUM IS USED
    Publication number: 20110038804
    Abstract: The invention relates to hyperpolarised 13C-?-ketoisocaproate, its use as imaging agent, an imaging medium comprising hyperpolarised 13C-?-ketoisocaproate and methods of 13C-MR detection wherein such an imaging medium is used. Further, the invention relates to methods of producing hyperpolarised 13C-?-ketoisocaproate.
    Type: Application
    Filed: December 19, 2008
    Publication date: February 17, 2011
    Inventors: Anna Gisselsson, George Hansson, Sven Mansson, Rene In't Zandt, Magnus Karlsson, Pernille R. Jensen, Mathilde H. Lerche
  • MR IMAGING AGENT OR MEDIUM COMPRESSING HYPERPOLARISED 13C ALANINE AND METHODS OF IMAGING WHEREIN SUCH AN IMAGING MEDIUM IS USED
    Publication number: 20110033390
    Abstract: The invention relates to hyperpolarised 13C-alanine, its use as imaging agent, an imaging medium comprising hyperpolarised 13C-alanine and methods of 13C-MR detection wherein such an imaging medium is used. Further, the invention relates to methods of producing hyperpolarised 13C-alanine.
    Type: Application
    Filed: February 3, 2009
    Publication date: February 10, 2011
    Inventors: Anna Gisselsson, Georg Hansson, Sven Mansson, Rene In't Zandt, Magnus Karlsson, Pernille R. Jensen, Mathilde H. Lerche
  • METHOD TO PRODUCE HYPERPOLARISED AMINO ACIDS AND AMINOSULPHONIC ACIDS
    Publication number: 20110008261
    Abstract: The invention relates to a dynamic nuclear polarisation (DNP) method for producing hyperpolarised amino acids and amino sulphonic acids and compositions for use in the method. As a sample, an ammonium salt of an amino acid, an ammonium salt of an aminosulphonic acid, a carboxylate salt of an amino acid, a sulphonate salt of an aminosulphonic acid or mixtures thereof is used.
    Type: Application
    Filed: February 3, 2009
    Publication date: January 13, 2011
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Mathilde H. Lerche, Magnus Karlsson, Pernille R. Jensen
  • COMPOSITION AND METHOD FOR GENERATING A METABOLIC PROFILE USING 13C-MR DETECTION
    Publication number: 20100310467
    Abstract: The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fumarate and imaging media comprising hyperpolarised 13C-fumarate for use in said method.
    Type: Application
    Filed: December 18, 2008
    Publication date: December 9, 2010
    Inventors: Anna Gisselsson, Georg Hansson, Sven Mansson, Rene In't Zandt, Magnus Karlsson, Pernille R. Jensen, Mathilde H. Lerche