Patents by Inventor Mathilde Lerche

Mathilde Lerche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intra-Operative Cancer Diagnosis Based on a Hyperpolarized Marker
    Publication number: 20150133341
    Abstract: The present invention is concerned with an in vitro method of diagnosing cancer in a tissue sample, wherein said tissue sample is obtained from a patient undergoing cancer surgery. The method described herein is based on a hyperpolarized marker, which is contacted with the tissue sample, and an NMR spectrum and/or an MR image obtained of the tissue sample after having been contacted with the hyperpolarized marker.
    Type: Application
    Filed: May 7, 2013
    Publication date: May 14, 2015
    Inventors: Mathilde Lerche, Magnus Karlsson, Pernille Rose Jensen
  • Method of cardiac imaging
    Patent number: 8980224
    Abstract: The invention relates to a method of cardiac imaging using hyperpolarised 13C-pyruvate as MR imaging agent, which allows determination of the viability of cells in the myocardium.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: March 17, 2015
    Assignee: GE Healthcare AS
    Inventors: Mathilde Lerche, Rene Zandt, Klaes Golman, Mikkel Thaning, Jan-Henrik Ardenkjaer-Larsen, Stefan Petersson
  • Method of Cardiac Imaging
    Publication number: 20090162287
    Abstract: The invention relates to a method of cardiac imaging using hyperpolarised 13C-pyruvate as MR imaging agent, which allows determination of the viability of cells in the myocardium.
    Type: Application
    Filed: November 18, 2005
    Publication date: June 25, 2009
    Inventors: Mathilde Lerche, Rene Zandt, Klaes Golman, Mikkel Thaning, Jan-Henrik Ardenkjaer-Larsen, Stefan Petersson
  • Nmr-based methods for detecting ligands, where the ligand or target are hyperpolarized and the nmr-spectrum is compared with a reference spectrum of the ligand or target
    Publication number: 20060171891
    Abstract: The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.
    Type: Application
    Filed: November 27, 2003
    Publication date: August 3, 2006
    Inventors: Jan-Henrik Ardenkjaer-Larsen, Herbert Baumann, Graham Cotton, Klaes Golman, Mark Howard, Mathilde Lerche, Rolf Servin, Mikkel Thaning, Jan Wolber
  • Method for phenotyping using nmr spectroscopy
    Publication number: 20050232864
    Abstract: The invention relates to methods for phenotyping by determining protein activity in vivo using at least one probe compound and enhancing the nuclear polarisation of NMR active nuclei present in the probe compound (hereinafter termed “hyperpolarisation”) prior to NMR analysis.
    Type: Application
    Filed: April 15, 2003
    Publication date: October 20, 2005
    Inventors: Bill Clark, Klaes Golman, Mathilde Lerche, Mike Looker, Mike O'Sullivan, Albie Santos, Rolf Servin, Mikkel Thaning, Jan-Henrik Ardenkjaer-Larsen
  • Methods and compound mixtures for determining protein activity using nmr spectroscopy
    Publication number: 20050233470
    Abstract: The invention relates to methods for determining protein activity using NMR spectroscopy. The present invention provides a method for determining protein activity in vivo using probe compounds and enhancing the nuclear polarisation of NMR active nuclei present in the probe compounds (hereinafter termed “hyperpolarisation”) prior to NMR analysis. The invention also provides mixtures of probe compounds for the above-mentioned method.
    Type: Application
    Filed: April 15, 2003
    Publication date: October 20, 2005
    Inventors: Bill Clark, Klaes Golman, Mathilde Lerche, Mike Looker, Mike O'Sullivan, Albie Santos, Rolf Servin, Mikkel Thaning, Jan-Henrik Ardenkjaer-Larsen
  • Method for characterizing metabolic stability of a drug
    Publication number: 20050170331
    Abstract: An NMR based method for characterising the metabolic stability of a drug candidate comprising the steps of enhancing the nuclear polarisation of NMR active nuclei present in the drug candidate (hereinafter termed “hyperpolarisation”), contacting the drug candidate with liver cells or cell organelles, and carrying out NMR analysis.
    Type: Application
    Filed: December 17, 2004
    Publication date: August 4, 2005
    Inventors: Mathilde Lerche, Klaes Golman