Abstract: An aspiration catheter may include a tubular body having a proximal end, a distal end, and a lumen extending therethrough. The distal end of the tubular body can be configured to provide aspiration in a first aspiration mode to apply a tension force to a clot positioned near the distal end along a longitudinal axis of the tubular body. The aspiration catheter can be configured to provide aspiration in a second aspiration mode at least when the clot is positioned within the distal end of the tubular body to apply a second force to the clot along a second axis different from the longitudinal axis. The catheter can include a stent-like backbone positioned along a sidewall of the catheter. The stent-like backbone can include a metallic support having a continuous gap extending longitudinally along a length of the backbone.

Abstract: An insert catheter having an elongate flexible body. The elongate flexible body has a proximal end, a distal end, a length of at least about 160 cm, a lumen extending from the proximal end to the distal end, and a side port in fluid communication with the lumen. The side port is positioned between about 30 cm to about 105 cm from the distal end of the elongate flexible body. A guidewire can extend through the lumen and the side port. The side port is configured to be positioned within a second interventional device during a neurovascular procedure. The insert catheter can have a pre-shaped tip on a distal portion of the elongate flexible body. The insert catheter can have a rail extending from the side port to the proximal end of the elongate flexible body. The rial can be configured to receive the guidewire.

Abstract: Described herein are various embodiments of valve systems that comprise a compressible region that is configured to reduce vacuum at a first port of the valve while substantially maintaining vacuum at a second port of the valve. Further described herein is an improved aspiration canister configured to maintain vacuum at a second vacuum line while a first vacuum line is disconnected from the canister.