Abstract: Systems and methods for imaging and analyzing a patient heart are described. Imaging can be performed with a variety or combination of methods, including single photon emission computed tomography, to provide a comprehensive, three-dimensional image or model of the heart including high-resolution details relating to scar tissue and other abnormalities. Data, including information related to the heart developed through the imaging process, can be analyzed to determine if a patient is a desirable candidate for cardiac resynchronization therapy. Specific details relating to a cardiac resynchronization therapy device and a procedure for implantation can be developed through analysis of available information. A heart model and “virtual roadmap” can be generated to guide a medical practitioner through patient-individualized procedures related to the specific details gleaned through analysis.