Abstract: Next generation therapeutics for treatment of microorganisms (especially bacterium, fungus or certain virus) and cancer and for fluorescence diagnosis are provided. Association complex(es) effective as bactericides are formed in situ by loose interactions of molecular entities. Adjustable variable associations reduce chance bacteria develops adaptive resistance versus a single bactericide structure or method. Multifunctional variations simultaneously or sequentially attack target cells and adjust level of reactive oxygen species produced such as singlet oxygen. Claimed systems are effective bactericides in aerobic and anaerobic conditions and in absence of or presence of visible light. In presence of visible light in aerobic conditions, such are cancer treatments. Preferred are water soluble, nontoxic association complex(es).

Abstract: Multifunctional compositions and methods are provided for therapeutic treatment of bacteria and cancers and for fluorescence diagnosis. Systems generate in situ reactive oxygen species such as singlet oxygen (1O2), hydroxyl radical (OH) and Juglone, and other chemotherapeutic agents. Methods provided selectively produce greater amounts of one reactive oxygen species over others. Variations are effective in aerobic, anaerobic or H2O2 rich environments and in presence of, or absence of, light. In H2O2 rich environment in absence of light, variations decompose H2O2 into O2 gas to remove excess H2O2 for elimination of hypoxic environment. Variations are formed of porphyrins, naphthalene derivatives, and metal ions, for illustration, free base tetrakis Ar substituted porphyrine core without metal or halide substitution but having hydroxyphenyl and alkyl pyridyl substituents at meso positions combined with dihydroxynaphthalene and +3 hydrated metal ions.

Abstract: Next generation therapeutics for treatment of microorganisms (especially bacterium, fungus or certain virus) and cancer and for fluorescence diagnosis are provided. Association complex(es) effective as bactericides are formed in situ by loose interactions of molecular entities. Adjustable variable associations reduce chance bacteria develops adaptive resistance versus a single bactericide structure or method. Multifunctional variations simultaneously or sequentially attack target cells and adjust level of reactive oxygen species produced such as singlet oxygen. Claimed systems are effective bactericides in aerobic and anaerobic conditions and in absence of or presence of visible light. In presence of visible light in aerobic conditions, such are cancer treatments. Preferred are water soluble, nontoxic association complex(es).

Abstract: Multifunctional compositions and methods are provided for therapeutic treatment of bacteria and cancers and for fluorescence diagnosis. Systems generate in situ reactive oxygen species such as singlet oxygen (1O2), hydroxyl radical (OH) and Juglone, and other chemotherapeutic agents. Methods provided selectively produce greater amounts of one reactive oxygen species over others. Variations are effective in aerobic, anaerobic or H2O2 rich environments and in presence of, or absence of, light. In H2O2 rich environment in absence of light, variations decompose H2O2 into O2 gas to remove excess H2O2 for elimination of hypoxic environment. Variations are formed of porphyrins, naphthalene derivatives, and metal ions, for illustration, free base tetrakis Ar substituted porphyrine core without metal or halide substitution but having hydroxyphenyl and alkyl pyridyl substituents at meso positions combined with dihydroxynaphthalene and +3 hydrated metal ions.