Patents by Inventor Matjaž Vogelsang

Matjaž Vogelsang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUPER-ENCHANCERS FOR RECOMBINANT GENE EXPRESSION IN CHO CELLS
    Publication number: 20230295666
    Abstract: Abstract: The present invention belongs to the field of biotechnology, and specifically relates to recombinant gene expression. The invention concerns a method of recombinant gene expression from a Chinese Hamster Ovary (CHO) cell, by using super-enhancer sequences for increased gene expression. Thus, the invention provides a method for producing an engineered CHO cell by introducing into the cell an exogenous nucleic acid molecule into or within 500 kb upstream or downstream of a super-enhancer as expression-enhancing sequence. The invention further provides an engineered CHO cell produced by the method. The invention further provides a method of producing a recombinant polypeptide. The invention is further directed to the use of a super-enhancer for transgene expression.
    Type: Application
    Filed: April 21, 2021
    Publication date: September 21, 2023
    Applicant: LEK Pharmaceuticals d.d.
    Inventors: Matjaž Vogelsang, Nika Tuta, Dominik Gaser