Patents by Inventor Mats Lake
Mats Lake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050070502Abstract: Dysglucaemia is treated and/or prevented by the administration of granulated starch, enzymatically degraded and releasing reducing sugars at a rate, adjusted to the metabolism of the patient, suffering from dysglucaemia. For example nocturnal hypoglycaemia in diabetic patients is prevented by administering to said patients a granulate or tablets comprising granulated cornstarch, and preferably also heat treated cornstarch and a low calorie sweetener. The inventive granulation minimises the available surface area and retards the enzymatic degradation of the cornstarch and ensures a controlled, e.g. a substantially linear release of reducing sugars, such as glucose, and a stable blood glucose level during several hours. The granulate or tablets are low in calories and contain no free sugar.Type: ApplicationFiled: September 30, 2004Publication date: March 31, 2005Applicant: METCON MEDICINE ABInventors: Henri Hansson, Mats Lake, Kerstin Hansson
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Publication number: 20050054611Abstract: The nutritional deficiencies which constitute a serious side-effect of intestinal cleansing procedures can be alleviated or entirely avoided by a composition and method according to the present invention, wherein a complex carbohydrate is administered to the patient in a form and an amount which gives a blood glucose response similar to that following a normal meal, and stabilizes the blood glucose level above 3.5 mmol/l, preferably above about 4 mmol/l, thus preventing hypoglycaemia. The composition and method is suitable for all patients, but in particular for weakened, elderly or diabetic patients. The composition and method significantly improves the well-being of the patients, and does not reduce the cleansing effect achieved by conventional intestinal cleansing preparations or procedures, and has no known side effects. The preferred complex carbohydrate is native corn starch, and the composition may also include a simple carbohydrate, e.g. sucrose.Type: ApplicationFiled: September 12, 2003Publication date: March 10, 2005Inventors: Mats Lake, Ulf Smith, Mette Axelsen, Eva Olausson
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Patent number: 6815436Abstract: Dysglucaemia is treated and/or prevented by the administration of granulated starch, enzymatically degraded and releasing reducing sugars at a rate, adjusted to the metabolism of the patient, suffering from dysglucaemia. For example nocturnal hypoglycaemia in diabetic patients is prevented by administering to said patients a granulate or tablets comprising granulated cornstarch, and preferably also heat treated cornstarch and a low calorie sweetener. The inventive granulation minimises the available surface area and retards the enzymatic degradation of the cornstarch and ensures a controlled, e.g. a substantially linear release of reducing sugars, such as glucose, and a stable blood glucose level during several hours. The granulate or tablets are low in calories and contain no free sugar.Type: GrantFiled: July 26, 2002Date of Patent: November 9, 2004Assignee: Metcon Medicin ABInventors: Henri Hansson, Mats Lake, Kerstin Hansson
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Patent number: 6815433Abstract: Dysglucaemia is treated and/or prevented by the administration of granulated starch, enzymatically degraded and releasing reducing sugars at a rate, adjusted to the metabolism of the patient, suffering from dysglucaemia. For example nocturnal hypoglycaemia in diabetic patients is prevented by administering to said patients a granulate or tablets comprising granulated cornstarch, and preferably also heat treated cornstarch and a low calorie sweetener. The inventive granulation minimizes the available surface area and retards the enzymatic degradation of the cornstarch and ensures a controlled, e.g. a substantially linear release of reducing sugars, such as glucose, and a stable blood glucose level during several hours. The granulate or tablets are low in calories and contain no free sugar.Type: GrantFiled: October 25, 2001Date of Patent: November 9, 2004Assignee: Metcon Medicin ABInventors: Henri Hansson, Mats Lake, Kerstin Hansson
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Publication number: 20040198699Abstract: Dysglucaemia is treated and/or prevented by the administration of granulated starch, enzymatically degraded and releasing reducing sugars at a rate, adjusted to the metabolism of the patient, suffering from dysglucaemia. For example nocturnal hypoglycaemia in diabetic patients is prevented by administering to said patients a granulate or tablets comprising granulated cornstarch, and preferably also heat treated cornstarch and a low calorie sweetener. The inventive granulation minimises the available surface area and retards the enzymatic degradation of the cornstarch and ensures a controlled, e.g. a substantially linear release of reducing sugars, such as glucose, and a stable blood glucose level during several hours. The granulate or tablets are low in calories and contain no free sugar.Type: ApplicationFiled: March 23, 2004Publication date: October 7, 2004Applicant: METCON MEDICIN ABInventors: Henri Hansson, Mats Lake, Kerstin Hansson
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Patent number: 6617134Abstract: Substantially pure dimers of Apolipoprotein AI-Milano (APO-AI-M/APO AI-M) were isolated from plasma and characterized. Apolipoprotein AI-M dimer can also be produced in a recombinant Escherichia coli system. Pharmaceutical compositions comprising the ApoAI-AI-M/ApoAI-M are described. Patients with atherosclerosis or cardiovascular diseases can be treated with the dimer. Medicaments containing the dimer can also be used to prevent thrombosis in different clinical circumstances, both at the arterial and at the venous level. The dimer can also act as a prodrug for the monomer.Type: GrantFiled: March 1, 1999Date of Patent: September 9, 2003Assignee: Esperion Therapeutics, Inc.Inventors: Cesare Sirtori, Guido Franceschini, Lars Abrahmsén, Erik Holmgren, Mats Lake, Björn Nilsson, Joanna Chmielewska, Peter Lind
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Publication number: 20030004135Abstract: Dysglucaemia is treated and/or prevented by the administration of granulated starch, enzymatically degraded and releasing reducing sugars at a rate, adjusted to the metabolism of the patient, suffering from dysglucaemia. For example nocturnal hypoglycaemia in diabetic patients is prevented by administering to said patients a granulate or tablets comprising granulated cornstarch, and preferably also heat treated cornstarch and a low calorie sweetener. The inventive granulation minimises the available surface area and retards the enzymatic degradation of the cornstarch and ensures a controlled, e.g. a substantially linear release of reducing sugars, such as glucose, and a stable blood glucose level during several hours. The granulate or tablets are low in calories and contain no free sugar.Type: ApplicationFiled: July 26, 2002Publication date: January 2, 2003Applicant: METCON MEDICIN ABInventors: Henri Hansson, Mats Lake, Kerstin Hansson
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Publication number: 20020094971Abstract: Dysglucaemia is treated and/or prevented by the administration of granulated starch, enzymatically degraded and releasing reducing sugars at a rate, adjusted to the metabolism of the patient, suffering from dysglucaemia. For example nocturnal hypoglycaemia in diabetic patients is prevented by administering to said patients a granulate or tablets comprising granulated cornstarch, and preferably also heat treated cornstarch and a low calorie sweetener. The inventive granulation minimises the available surface area and retards the enzymatic degradation of the cornstarch and ensures a controlled, e.g. a substantially linear release of reducing sugars, such as glucose, and a stable blood glucose level during several hours. The granulate or tablets are low in calories and contain no free sugar.Type: ApplicationFiled: October 25, 2001Publication date: July 18, 2002Applicant: Metcon Medicin ABInventors: Henri Hansson, Mats Lake, Kerstin Hansson
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Patent number: 5876968Abstract: Substantially pure dimers of Apolipoprotein Al-Milano (Al-M/APO Al-M) isolated and characterized from plasma are provided. Pharmaceutical compositions comprising the Apo Al-M/Apo Al-M are also provided. Apolipoprotein Al-M dimer can be produced in a recombinant Escherichia coli system or collected from plasma from Apolipoprotein Al-Milano carriers. Atherosclerosis and cardiovascular diseases can be treated with the dimer. Medicaments containing the dimer can also be used for preventing thrombosis in different clinical circumstances, both at the arterial and at the venous level. The dimer can also act as a prodrug for the monomer.Type: GrantFiled: November 4, 1993Date of Patent: March 2, 1999Assignee: Pharmacia & Upjohn AktiebolagInventors: Cesare Sirtori, Guido Franceschini, Lars Abrahmsen, Erik Holmgren, Mats Lake, Bjorn Nilsson, Joanna Chmielewska, Peter Lind
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Patent number: 5721114Abstract: The invention relates to an expression system giving high extracellular production of apolipoprotein AI-M (Milano) using E. coli and comprises a plasmid carrying an origin of replication, an inducible promoter sequence, a DNA sequence coding for a signal peptide, a DNA sequence coding for apolipoprotein AI-M, and a transcription terminator. The invention also relates to a method of producing apolipoprotein AI-M using the expression system.Type: GrantFiled: August 25, 1995Date of Patent: February 24, 1998Assignee: Pharmacia & Upjohn AktiebolagInventors: Lars Abrahamsen, Erik Holmgren, Christina Kalderen, Mats Lake, .ANG.sa Mikaelsson, Torsten Sejlitz
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Patent number: 5525593Abstract: The use of IGF-II for preparing a medicament for the regeneration of muscle tissue; and methods for medical treatment for the purpose of regenerating muscle tissue, for minimizing scar formation during healing of a wound or for preventing undesired tissue adhesion after injury, such as after surgery.Type: GrantFiled: January 26, 1994Date of Patent: June 11, 1996Assignee: Pharmacia ABInventors: Mats Lake, Eva Jennische