Patents by Inventor Mats Reslow
Mats Reslow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150250882Abstract: The present invention relates to growth hormone compositions comprising a fatty acid acylated amino acids (FA-aa's), which may be used in pharmaceutical compositions such as pharmaceutical compositions for oral administration of growth hormone.Type: ApplicationFiled: October 17, 2013Publication date: September 10, 2015Inventors: Mats Reslow, Leif Noerskov-Lauritsen, Heidi Westh Bagger, Christine Bruun Schioedt
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Patent number: 8293708Abstract: Pharmaceutical compositions comprising pegylated growth hormone at pH 7 or below are provided.Type: GrantFiled: August 30, 2006Date of Patent: October 23, 2012Assignee: Novo Nordisk Health Care A/GInventor: Mats Reslow
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Publication number: 20120108512Abstract: The invention relates to stable pharmaceutical compositions comprising a therapeutic peptide derivatized with a property-modifying group, wherein the property-modifying group is conjugated to the peptide by use of a linker comprising an oxime bond.Type: ApplicationFiled: May 7, 2010Publication date: May 3, 2012Applicant: Novo Nordisk Health Care AGInventor: Mats Reslow
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Publication number: 20090325865Abstract: Pharmaceutical compositions comprising pegylated growth hormone at pH 7 or below are provided.Type: ApplicationFiled: August 30, 2006Publication date: December 31, 2009Applicant: Novo Nordisk Health Care AGInventor: Mats Reslow
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Publication number: 20070142325Abstract: Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, subjecting the starch to a molecular weight reduction by acid hydrolysis, and optionally removing residual water-soluble proteins. Purified starch and microparticles based on such starch.Type: ApplicationFiled: February 2, 2007Publication date: June 21, 2007Inventors: Nils Gustavsson, Monica Jonsson, Per Berden, Timo Laakso, Mats Reslow
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Publication number: 20070122484Abstract: A process for producing microparticles containing biologically active substance, in which process an aqueous solution of the said substance is prepared, this solution is mixed with an aqueous solution of PEG such that the substance is concentrated and/or solidified, the substance is optionally washed, the substance is mixed with an aqueous starch solution, the composition obtained is mixed, after the admixture of the starch solution, with a polymer solution, thereby forming an emulsion of starch droplets in the polymer solution, the starch droplets are solidified into microparticles, the microparticles are dried and a release-controlling shell is optionally applied to these. Novel microparticles which are obtainable by means of this process.Type: ApplicationFiled: December 22, 2006Publication date: May 31, 2007Inventors: Monica Jonsson, Timo Laakso, Mats Reslow
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Publication number: 20060257479Abstract: Sustained release formulations comprising molecules modified so as to have a reduced clearance is provided.Type: ApplicationFiled: March 31, 2006Publication date: November 16, 2006Applicant: Novo Nordisk A/SInventors: Simon Jensen, Lars Iversen, Christian Rischel, Mats Reslow
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Patent number: 7105181Abstract: A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 ?g and have no covalent chemical cross-linking.Type: GrantFiled: November 10, 2003Date of Patent: September 12, 2006Assignee: Jagotec, AGInventors: Nils Ove Gustavsson, Monica Jönsson, Timo Laakso, Mats Reslow
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Patent number: 7033609Abstract: A parenterally administrable, biodegradable microparticle preparation containing a biologically active substance which, during the first 24 hours after injection, exhibits a release of the active substance that is less than 25% of the total release, determined from a concentration-time curve in the form of the ratio between the area under the curve during the said first 24 hours and the total area under the curve in questionType: GrantFiled: January 10, 2002Date of Patent: April 25, 2006Assignee: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jönsson, Timo Laakso, Mats Reslow, Sören Björn, Jörn Drustrup
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Patent number: 6936278Abstract: A process for producing microparticles, in which an aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, the gelled starch particles are dried, and a release-controlling shell is optionally applied to the particles, wherein at least one buffer substance having the ability of keeping the pH of the produced microparticles above 3 if exposing the microparticles to an aqueous evironment is added at any stage during the process. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 ?g and have no covalent chemical cross-linking and which have the aktivity of keeping the pH above 3 if exposed to a aqueous environment.Type: GrantFiled: June 6, 2002Date of Patent: August 30, 2005Assignee: Jagotec AGInventors: Mats Reslow, Monica Jönsson, Karin Larsson, Timo Laakso
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Patent number: 6861064Abstract: A novel method of encapsulating an active substance in a biodegradable polymer, which comprises: a) dissolving said biodegradable polymer in an organic solvent therefor; b1) dispersing said active substance in the organic solution obtained in step a) to provide a dispersion with the active substance as the inner phase thereof; or alternatively b2) emulsifying said active substance, dissolved in water or other aqueous solvent therefor, in the organic solution obtained in step a) to provide an emulsion with the active substance as the inner aqueous phase thereof; and c) subjecting the dispersion obtained in step b1), or alternatively the emulsion obtained in step b2), to an encapsulation operation with an aqueous polyethylene glycol solution as a continuous phase to provide micro- or nanoparticles having the active substance encapsulated therein. Sustained release particles obtainable thereby.Type: GrantFiled: September 24, 1998Date of Patent: March 1, 2005Assignee: Jagotec AGInventors: Timo Laakso, Mats Reslow
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Publication number: 20040115281Abstract: A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles.Type: ApplicationFiled: November 10, 2003Publication date: June 17, 2004Inventors: Nils Ove Gustavsson, Monica Jonsson, Timo Laakso, Mats Reslow
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Patent number: 6706288Abstract: A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 &mgr;g and have no covalent chemical cross-linking.Type: GrantFiled: October 5, 2001Date of Patent: March 16, 2004Assignee: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jönsson, Timo Laakso, Mats Reslow
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Patent number: 6692770Abstract: A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are med to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 &mgr;g and have no covalent chemical cross-linking.Type: GrantFiled: June 16, 2003Date of Patent: February 17, 2004Assignee: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jönsson, Timo Laakso, Mats Reslow
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Patent number: 6689389Abstract: Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, dissolving the starch in aqueous medium, molecular weight reduction by shearing, and optionally removal of residual water-soluble proteins, preferably by anion exchange chromatography. Purified starch and microparticles based on such starch.Type: GrantFiled: October 5, 2001Date of Patent: February 10, 2004Assignee: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jönsson, Per Berdén, Timo Laakso, Mats Reslow
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Publication number: 20030211167Abstract: A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles.Type: ApplicationFiled: June 16, 2003Publication date: November 13, 2003Applicant: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jonsson, Timo Laakso, Mats Reslow
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Publication number: 20030206961Abstract: Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, subjecting the starch to a molecular weight reduction by acid hydrolysis, and optionally removing residual water-soluble proteins.Type: ApplicationFiled: June 16, 2003Publication date: November 6, 2003Applicant: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jonsson, Per Berdeh, Timo Laakso, Mats Reslow
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Publication number: 20030180371Abstract: A process for producing microparticles, in which an aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, the gelled starch particles are dried, and a release-controlling shell is optionally applied to the particles, wherein at least one buffer substance having the ability of keeping the pH of the produced microparticles above 3 if exposing the microparticles to an aqueous evironment is added at any stage during the process.Type: ApplicationFiled: June 6, 2002Publication date: September 25, 2003Inventors: Mats Reslow, Monica Jonsson, Karin Larsson, Timo Laakso
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Patent number: 6616948Abstract: Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, subjecting the starch to a molecular weight reduction by acid hydrolysis, and optionally removing residual water-soluble proteins. Purified starch and microparticles based on such starch.Type: GrantFiled: October 5, 2001Date of Patent: September 9, 2003Assignee: Jagotec AGInventors: Nils Ove Gustavsson, Monica Jönsson, Per Berdén, Timo Laakso, Mats Reslow
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Patent number: 6616949Abstract: A process for producing microparticles containing biologically active substance, in which process an aqueous solution of the said substance is prepared, this solution is mixed with an aqueous solution of PEG such that the substance is concentrated and/or solidified, the substance is optionally washed, the substance is mixed with an organic polymer solution, the composition obtained is mixed, after the admixture of said polymer solution, with an aqueous polymer solution, thereby forming an emulsion of droplets of first mentioned polymer as the internal phase, said droplets are solidified into microparticles, the microparticles are dried and a release-controlling shell is optionally applied to these.Type: GrantFiled: October 5, 2001Date of Patent: September 9, 2003Assignee: Jagotec AGInventors: Monica Jönsson, Timo Laakso, Mats Reslow