Abstract: The application describes methods for making a deuterated dextromethorphan of Formula (I), deuterated dextromethorphan produced by these methods, and pharmaceutically acceptable salts thereof.

Abstract: This disclosure describes a payload pipeline system that, as part of an inter-network facilitation system, can facilitate digital payload throughput between network components using a staggered payload relayer. For example, the disclosed systems utilize custom tooling to implement a staggered payload relayer as an intelligent conduit or pipeline that operates as a publisher-subscriber paradigm system (as opposed to a data stream system). In some cases, the disclosed systems can utilize synchronous or asynchronous communication to receive digital payloads for events from publisher network components and to make the digital payloads available within a payload queue maintained by the staggered payload relayer (for access by subscriber network components).

Abstract: The application describes methods for making a deuterated dextromethorphan of Formula (I), deuterated dextromethorphan produced by these methods, and pharmaceutically acceptable salts thereof.

Abstract: A voltage controlled oscillator (VCO) includes a sensing circuit, where the sensing circuit is configured to generate a plurality of compensation control signals. The VCO further includes a voltage-to-current converter comprising a plurality of current sources which are configured to generate a current signal in response to the plurality of compensation control signals. Additionally, the VCO includes a plurality of switching circuits, each of the plurality of switching circuits being configured to selectively enable or disable a corresponding one of the plurality of current sources in response to a corresponding one of the plurality of compensation control signals. Furthermore, the VCO includes a current controlled oscillator configured to generate an oscillating signal in response to the current signal.

Abstract: The present disclosure relates to a clock generation system. The system includes a clock source, a tuning buffer, an output buffer, a duty cycle measurement circuit and an automatic calibration component. The clock source generates a clock signal. The tuning buffer is configured to generate a corrected clock signal from the clock signal according to adjustment values. The output buffer is configured to generate an output clock signal from the corrected clock signal. The duty cycle measurement circuit is configured measure a duty cycle of the output clock signal. The automatic calibration component is configured to generate the adjustment values according to the duty cycle measurement and the specification values.

Abstract: A voltage controlled oscillator (VCO) includes a sensing circuit, where the sensing circuit is configured to generate a plurality of compensation control signals. The VCO further includes a voltage-to-current converter comprising a plurality of current sources which are configured to generate a current signal in response to the plurality of compensation control signals. Additionally, the VCO includes a plurality of switching circuits, each of the plurality of switching circuits being configured to selectively enable or disable a corresponding one of the plurality of current sources in response to a corresponding one of the plurality of compensation control signals. Furthermore, the VCO includes a current controlled oscillator configured to generate an oscillating signal in response to the current signal.

Abstract: A voltage controlled oscillator (VCO) includes a current controlled oscillator, a voltage-to-current converter, and a sensing circuit. The sensing circuit includes a delay unit, and the sensing circuit is configured to generate a plurality of compensation control signals in response to a time delay of the delay unit. The voltage-to-current converter is configured to generate a current signal in response to a VCO control signal and the plurality of compensation control signals. The current controlled oscillator is configured to generate an oscillating signal in response to the current signal.

Abstract: The present disclosure relates to a clock generation system. The system includes a clock source, a tuning buffer, an output buffer, a duty cycle measurement circuit and an automatic calibration component. The clock source generates a clock signal. The tuning buffer is configured to generate a corrected clock signal from the clock signal according to adjustment values. The output buffer is configured to generate an output clock signal from the corrected clock signal. The duty cycle measurement circuit is configured measure a duty cycle of the output clock signal. The automatic calibration component is configured to generate the adjustment values according to the duty cycle measurement and the specification values.