Abstract: Some embodiments include an x-ray detector, comprising: a plastic housing; a two-dimensional sensor array disposed in a within the plastic housing and configured to generate image data in response to incident x-rays; a front plate connected to the plastic housing, the front plate and the plastic housing forming an enclosure surrounding the two-dimensional sensor array; and a printed circuit board mounted to the plastic housing at a plurality of mount points. wherein a centroid of the printed circuit board is closer to a center of the plastic housing than a centroid of the mount points.

Abstract: The invention relates to therapeutic compositions for disorders associated with haploinsufficiency. The invention provides antisense oligonucleotides useful for treating neurodevelopmental disorders associated with mutations in the SYNGAP gene. The invention provides compositions that include synthetic antisense oligonucleotides (ASOs) that promote expression of the SynGAP protein by one or any combination of (i) preventing one or more miRNAs from interfering with production of the SynGAP protein; (ii) binding to the 5?-UTR of the SYNGAP1 transcript and augmenting translation of the Syngap protein; and (iii) promoting RNAseH cleavage of antisense long non-coding RNAs that are anticorrelated with SYNGAP expression. When the composition is delivered to a patient with SYNGAP haploinsufficiency, the ASOs promote expression of the SynGAP protein.

Abstract: The invention relates to therapeutic compositions for disorders associated with haploinsufficiency. The invention provides antisense oligonucleotides useful for treating early-onset epileptic encephalopathy by promoting expression of Syntaxin-binding protein 1 (STXBP1). The invention provides compositions that include synthetic antisense oligonucleotides (ASOs) that prevent certain miRNAs from interfering with production of the STXBP1 protein or bind to the 5?-UTR of the STXBP1 transcript and augment translation of the STXBP1 protein. When the composition is delivered to a patient with STXBP1 haploinsufficiency, the ASOs prevent miRNA from downregulating synthesis of STXBP1 protein.

Abstract: Some embodiments include a radiographic imaging system, comprising: a radiographic imager, including: an imaging array; imager control logic configured to control the imaging array; a power system configured to supply power to at least the imaging array and the imager control logic; a wireless power receiver configured to receive energy wirelessly and provide at least part of that energy to the power system; and a wireless communication transmitter; and a charging mat, including: a wired power input; a wireless power transmitter configured to transmit energy wirelessly; and a wireless communication receiver; wherein the wireless power receiver, the wireless power transmitter, the wireless communication receiver, and the wireless communication transmitter are positioned such that the radiographic imager can be placed on the charging mat where, simultaneously, the wireless power receiver is aligned with the wireless power transmitter and the wireless communication receiver is aligned with the wireless communica

Abstract: Some embodiments include an x-ray system, comprising: an x-ray detector comprising: a housing; a sensor array configured to generate an image in response to incident x-ray radiation and disposed in the housing; a control circuit coupled to the sensor array, configured to control the sensor array, and disposed in the housing; and a first connector interface disposed on an exterior of the housing and electrically connected to the control circuit; an adapter comprising: a second connector interface configured to physically and electrically mate with the first connector interface; a third connector interface having at least one of a physical configuration and an electrical configuration different from the first connector interface; and a plurality of electrical connections between the second connector interface and the third connector interface.

Abstract: Some embodiments include an x-ray detector, comprising: a plastic housing including a conductive coating; a two-dimensional sensor array disposed in a within the plastic housing and configured to generate image data in response to incident x-rays; a front plate connected to the plastic housing, the front plate and the plastic housing forming an enclosure surrounding the two-dimensional sensor array; wherein the conductive coating and the front plate form at least part of an electromagnetic interference shield around the two-dimensional sensor array.

Abstract: Some embodiments include a radiographic imaging system, comprising: a radiographic imager, including: an imaging array; imager control logic configured to control the imaging array; a power system configured to supply power to at least the imaging array and the imager control logic; a wireless power receiver configured to receive energy wirelessly and provide at least part of that energy to the power system; and a wireless communication transmitter; and a charging mat, including: a wired power input; a wireless power transmitter configured to transmit energy wirelessly; and a wireless communication receiver; wherein the wireless power receiver, the wireless power transmitter, the wireless communication receiver, and the wireless communication transmitter are positioned such that the radiographic imager can be placed on the charging mat where, simultaneously, the wireless power receiver is aligned with the wireless power transmitter and the wireless communication receiver is aligned with the wireless communica