Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: A dampening system for a tire-bead loosener may have a lever in communication with an operation valve, the operation valve configured to channel a supply flow having a supply flow pressure through a first line into a first port of a cylinder and an exhaust flow having an exhaust flow pressure through a second line out of a second port of the cylinder. A pressure line connecting the first line to the second line may include a preset pressure relief valve, a pressure regulator, and a check valve. A bypass flow of the supply flow may move through the pressure line and achieve a damped pressure, thereby channeling through the second line and into the second port of the cylinder. The supply flow pressure in the first port of the cylinder may be cushioned against the exhaust flow pressure and the damped pressure in the second port of the cylinder.