Patents by Inventor Matteo DE POLI

Matteo DE POLI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic process for the preparation of Droxidopa
    Patent number: 11434197
    Abstract: The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear or branched alkyl group and R4 is hydrogen or an amine protecting group.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: September 6, 2022
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Stefano Fogal, Paolo Stabile, Pierluigi Padovan, Matteo De Poli, Angelo Restelli
  • Highly stable crystalline Eltrombopag monoethanolamine salt form D1
    Patent number: 11267791
    Abstract: Object of the present invention is a highly stable crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D1, having the highest thermodynamically stability with excellent non-hygroscopicity, and particularly well suitable for pharmaceutical purposes, with related process.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: March 8, 2022
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Nicolas Tesson, Jordi De Mier Vinue, Paolo Stabile, Pierluigi Padovan, Matteo De Poli, Angelo Restelli
  • Crystalline Eltrombopag monoethanolamine salt form D
    Patent number: 11214547
    Abstract: Object of the present invention is a better crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D, stable, suitable for pharmaceutical purposes, and with the highest solubility in water and excellent non-hygroscopicity, then the related process and intermediates thereof.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: January 4, 2022
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Nicolas Tesson, Jordi De Mier Vinue, Paolo Stabile, Pierluigi Padovan, Matteo De Poli, Angelo Restelli
  • HIGHLY STABLE CRYSTALLINE ELTROMBOPAG MONOETHANOLAMINE SALT FORM D1
    Publication number: 20210284611
    Abstract: Object of the present invention is a highly stable crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D1, having the highest thermodynamically stability with excellent non-hygroscopicity, and particularly well suitable for pharmaceutical purposes, with related process.
    Type: Application
    Filed: July 25, 2019
    Publication date: September 16, 2021
    Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Nicolas TESSON, Jordi DE MIER VINUE, Paolo STABILE, Pierluigi PADOVAN, Matteo DE POLI, Angelo RESTELLI
  • CRYSTALLINE ELTROMBOPAG MONOETHANOLAMINE SALT FORM D
    Publication number: 20210198211
    Abstract: Object of the present invention is a better crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D, stable, suitable for pharmaceutical purposes, and with the highest solubility in water and excellent non-hygroscopicity, then the related process and intermediates thereof.
    Type: Application
    Filed: July 25, 2019
    Publication date: July 1, 2021
    Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Nicolas TESSON, Jordi DE MIER VINUE, Paolo STABILE, Pierluigi PADOVAN, Matteo DE POLI, Angelo RESTELLI
  • ENZYMATIC PROCESS FOR THE PREPARATION OF DROXIDOPA
    Publication number: 20210163401
    Abstract: The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear or branched alkyl group and R4 is hydrogen or an amine protecting group.
    Type: Application
    Filed: June 7, 2019
    Publication date: June 3, 2021
    Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Stefano FOGAL, Paolo STABILE, Pierluigi PADOVAN, Matteo DE POLI, Angelo RESTELLI