Abstract: Analysis system for the quantitative chemical analysis of samples includes a detection equipment to detect the quantity of target analytes in the samples to be analyzed, which includes a chromatography system, an ion source and a mass spectrometer; a data processing system to process quantitative data of the target analytes in the samples analyzed, as detected by the detection equipment; and an innovative database containing corrective and control data and coefficients to calibrate and correct the instrumental response of the detection equipment, wherein the corrective and control data and coefficients are determined and acquired by the database before the actual analysis of the samples, the sample being prepared with a universal dilution solution to minimize the corresponding matrix effect, the data processing system determining the quantitative data of the target analytes by processing the quantitative data taking account of the corrective and control data and coefficients contained in the database.