Abstract: Provided herein are compositions and methods for enhancing the activity of Stimulator of Interferon Genes (STING) with one or more agents for inhibiting the activity of one or more negative regulators of STING, including DNAJC13 and ESCRT.

Abstract: A method and a system perform dynamic exposition of data from a data repository. The method includes the steps of: providing one or more data model entities relevant to the data to be exposed; creating a controller for the or each data model entity; compiling the or each controller thereby creating a respective artifact; and processing the artifact(s) to obtain the data exposition at a data exposition host. The step of providing at least one data model entity includes creating a logical, human-readable representation of the data model (e.g. a metamodel), and the steps of creating and compiling the or each controller and creating and processing the artifact(s) are automatically performed starting from the metamodel(s) when a user modifies the latter and requests data exposition.

Abstract: A system and a method for controlling the operations of a manufacturing facility with production resources that execute a production process and a manufacturing execution system with a production modeler and a production scheduler. A man-machine interface and/or graphical user interface enable the user to enter production orders and production scheduling data into the execution system. A production scheduler database stores production orders and production scheduling data. A data server process updates sensitive data that are required for real-time scheduling when a user modifies sensitive data. The data server process executes an event list queue with the data modification events launched by the database, periodically checks the event list queue for data modification events, reads from the database only the modified data of the sensitive data and/or sensitive class of data, and merges the modified data with the existing data. The updated data are then accessible to all users.

Abstract: A system and a method for controlling the operations of a manufacturing facility with production resources that execute a production process and a manufacturing execution system with a production modeler and a production scheduler. A man-machine interface and/or graphical user interface enable the user to enter production orders and production scheduling data into the execution system. A production scheduler database stores production orders and production scheduling data. A data server process updates sensitive data that are required for real-time scheduling when a user modifies sensitive data. The data server process executes an event list queue with the data modification events launched by the database, periodically checks the event list queue for data modification events, reads from the database only the modified data of the sensitive data and/or sensitive class of data, and merges the modified data with the existing data. The updated data are then accessible to all users.