Patents by Inventor Matteo Righi

Matteo Righi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Blower
    Patent number: 11963486
    Abstract: The invention describes a blower (1) comprising: a volute (10) for conveying air, a first tube (15) connected to the conveying volute (10), a second tube (50) adapted for being at least partially inserted in the first tube (15) and for sliding inside it along a sliding direction (A), and a fixing system of the second tube (50) to the first tube (15) in at least two positions, one of which is extracted and one is retracted.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: April 23, 2024
    Assignee: Emak S.P.A.
    Inventor: Matteo Righi
  • CELL
    Publication number: 20240075066
    Abstract: The present invention relates to a cell comprising a chimeric antigen receptor (CAR) and a constitutively active or inducible Signal Transducer and Activator of Transcription (STAT) molecule.
    Type: Application
    Filed: May 24, 2023
    Publication date: March 7, 2024
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Matteo Righi
  • METHOD
    Publication number: 20230256093
    Abstract: The present invention provides a method for treating a solid cancer which comprises the step of administering a cell to a subject, wherein the cell comprises a nucleic acid sequence encoding interleukin 12 (IL-12) downstream of a frame-slip motif (FSM) or a translational readthrough motif (TRM).
    Type: Application
    Filed: May 12, 2021
    Publication date: August 17, 2023
    Inventors: Marco Della Peruta, Matteo Righi, Giulia Agliardi, Martin Pulé, Shaun Cordoba, James Sillibourne
  • Cell
    Patent number: 11701386
    Abstract: The present invention relates to a cell comprising a chimeric antigen receptor (CAR) and a constitutively active or inducible Signal Transducer and Activator of Transcription (STAT) molecule.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: July 18, 2023
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Matteo Righi
  • Polypeptide
    Patent number: 11648274
    Abstract: The present invention provides a chimeric polypeptide comprising: an antigen-binding domain which constitutively binds to an ectodomain of a first chain of a cytokine receptor; a transmembrane domain; and an endodomain from a second chain of the cytokine receptor which chimeric polypeptide, when expressed in a cell, binds to the endogenous first chain of the cytokine receptor causing constitutive cytokine signalling.
    Type: Grant
    Filed: November 23, 2018
    Date of Patent: May 16, 2023
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Matteo Righi, Simon Thomas, Shimobi Onuoha, Shaun Cordoba
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20230133682
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokinc and a cell-surface antigen; and (ii) a cytokine receptor cndodomain.
    Type: Application
    Filed: July 26, 2022
    Publication date: May 4, 2023
    Inventors: Martin PULÉ, Shaun CORDOBA, Matteo RIGHI, James SILLIBOURNE, Shimobi ONUOHA, Simon THOMAS
  • Methods for treating cancer or modulating T cells or NK cells in a subject with cancer by administering cells comprising chimeric cytokine receptors
    Patent number: 11479614
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: October 25, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • Methods for treating cancer or modulating T cells or NK cells in a subject by administering cells comprising chimeric transmembrane proteins
    Patent number: 11479613
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: October 25, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20220289820
    Abstract: The present invention provides a chimeric cytokine receptor comprising a cytokine receptor endodomain which comprises a first chain and a second chain, wherein the first and/or second chain of the cytokine-receptor endodomain is/are truncated. The invention also provides cells comprising such a chimeric cytokine receptor, optionally in combination with a chimeric antigen receptor (CAR) and their use in the treatment of diseases such as cancer.
    Type: Application
    Filed: August 4, 2020
    Publication date: September 15, 2022
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onouha, Matteo Righi
  • RECEPTOR
    Publication number: 20220275052
    Abstract: The present invention provides a chimeric receptor which comprises: a ligand-binding exodomain; and an endodomain which comprises: (i) a cytokine receptor endodomain; and (ii) an intracellular T cell signalling domain.
    Type: Application
    Filed: December 22, 2021
    Publication date: September 1, 2022
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi
  • Cell
    Patent number: 11365262
    Abstract: The present invention provides a cell which comprises a first chimeric antigen receptor (CAR) and a second CAR, wherein the first and second CARs bind different epitopes on the same ligand. The cell may be used in a method for treating a disease, such as cancer.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: June 21, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne
  • Chimeric receptor with ligand binding exodomain and cytokine and T cell signalling endodomains
    Patent number: 11242377
    Abstract: The present invention provides a chimeric receptor which comprises: a ligand-binding exodomain; and an endodomain which comprises: (i) a cytokine receptor endodomain; and (ii) an intracellular T cell signalling domain.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: February 8, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20210040228
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Application
    Filed: August 20, 2020
    Publication date: February 11, 2021
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20210040227
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Application
    Filed: August 20, 2020
    Publication date: February 11, 2021
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • BLOWER
    Publication number: 20210007294
    Abstract: The invention describes a blower (1) comprising: a volute (10) for conveying air, a first tube (15) connected to the conveying volute (10), a second tube (50) adapted for being at least partially inserted in the first tube (15) and for sliding inside it along a sliding direction (A), and a fixing system of the second tube (50) to the first tube (15) in at least two positions, one of which is extracted and one is retracted.
    Type: Application
    Filed: April 1, 2019
    Publication date: January 14, 2021
    Applicant: EMAK S.P.A.
    Inventor: Matteo RIGHI
  • POLYPEPTIDE
    Publication number: 20200360432
    Abstract: The present invention provides a chimeric polypeptide comprising: an antigen-binding domain which constitutively binds to an ectodomain of a first chain of a cytokine receptor; a transmembrane domain; and an endodomain from a second chain of the cytokine receptor which chimeric polypeptide, when expressed in a cell, binds to the endogenous first chain of the cytokine receptor causing constitutive cytokine signalling.
    Type: Application
    Filed: November 23, 2018
    Publication date: November 19, 2020
    Inventors: Martin Pulé, Matteo Righi, Simon Thomas, Shimobi Onuoha, Shaun Cordoba
  • Chimeric cytokine receptors and encoding nucleic acids
    Patent number: 10800854
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: October 13, 2020
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • Chimeric cytokine receptors and encoding nucleic acids
    Patent number: 10800855
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: October 13, 2020
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • CELL
    Publication number: 20200297766
    Abstract: The present invention relates to a cell comprising a chimeric antigen receptor (CAR) and a constitutively active or inducible Signal Transducer and Activator of Transcription (STAT) molecule.
    Type: Application
    Filed: September 12, 2018
    Publication date: September 24, 2020
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Matteo Righi
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20190016820
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Application
    Filed: August 27, 2018
    Publication date: January 17, 2019
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas