Patents by Inventor Matteo Valli

Matteo Valli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF A KEY INTERMEDIATE OF SIPONIMOD
    Publication number: 20230322658
    Abstract: The present invention relates to a process for the preparation of a key intermediate and other intermediates useful for the synthesis of Siponimod, a drug used for the treatment of multiple sclerosis. Object of the invention are also said novel intermediates.
    Type: Application
    Filed: July 30, 2021
    Publication date: October 12, 2023
    Applicant: OLON S.P.A.
    Inventors: Matteo VALLI, Mara SADA, Lazzaro FELICIANI, Giorgio BERTOLINI
  • Process for the preparation of lifitegrast
    Patent number: 11498917
    Abstract: The invention relates to a process for the preparation of Lifitegrast of formula (I), which comprises: a) condensation of the compound of formula (II) with the compound of formula (III) to give the compound of formula (IV) wherein R1, R2 and R3 are independently selected from straight or branched C1-C6 alkyl groups; b) chlorination of compound (IV) in the presence of a chlorinating agent (IV), (V), c) condensation of compound (V) with amino acid (VI) to give compound (I), c) condensation of compound (V) with amino acid (VI) to give compound (I), d) optional purification of the crude Lifitegrast in mixtures of polar aprotic solvents and water.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: November 15, 2022
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Lazzaro Feliciani, Davide Longoni, Mara Sada, Matteo Valli
  • PROCESS FOR THE PREPARATION OF LIFITEGRAST
    Publication number: 20210246123
    Abstract: The invention relates to a process for the preparation of Lifitegrast of formula (I), which comprises: a) condensation of the compound of formula (II) with the compound of formula (III) to give the compound of formula (IV) wherein R1, R2 and R3 are independently selected from straight or branched C1-C6 alkyl groups; b) chlorination of compound (IV) in the presence of a chlorinating agent (IV), (V), c) condensation of compound (V) with amino acid (VI) to give compound (I), c) condensation of compound (V) with amino acid (VI) to give compound (I), d) optional purification of the crude Lifitegrast in mixtures of polar aprotic solvents and water.
    Type: Application
    Filed: June 13, 2019
    Publication date: August 12, 2021
    Applicant: OLON S.P.A.
    Inventors: Giorgio Bertolini, Lazzaro Feliciani, Davide Longoni, Mara Sada, Matteo Valli