Abstract: A method is provided for reducing the severity and/or frequency of symptoms or clinical manifestations resulting from gluten ingestion by administering to a seropositive patient with symptomatic celiac disease, gluten intolerance, or gluten sensitivity latiglutenase (ALV003) in an amount from about 100 mg to about 1200 mg per day.

Abstract: A packaged pharmaceutical product having extended shelf life includes a pharmaceutical preparation comprising chlorobutanol and a dispensing container. The container has a hollow body, having an open end therein and is formed from a blend of low density polyethylene, having high chlorobutanol permeability, and a polypropylene, having low chlorobutanol permeability. A body wall thickness, enables both drop-by-drop dispensing of the pharmaceutical preparation by manual squeezing of the body, and, in combination with the blend of polymers, preventing significant loss of chlorobutanol through the body wall upon storage of the container with the body filled with the pharmaceutical preparation. A dropper tip fixed to the body open end is provided for forming droplets of pharmaceutical preparation upon manual squeezing of the body.