Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: An electronic access control system and method that enables conditional access to electronic locking systems according to user-based and situation-based safety parameters. Aspects of the present disclosure provide for a mobile access interface whereby the network operations center can assess a safety risk for a service site based on a combination of user-generated inputs, sensor inputs and/or external data inputs. The system may comprise a dynamic rules engine configured to dynamically determine safety and compliance associated with an access-restricted area. If the access-restricted area is safe, the system may enable access according to one or more access protocols. If the access-restricted area is unsafe, or the user requesting access is not in compliance with one or more static or dynamic safety parameters, the system may disable standard access protocols and deny access to the requesting party.

Abstract: A method for forming a multi-layered structure includes forming a resin-infused fibrous material (70) by applying a liquid resin component (60) onto the fibrous material (32) being pulled through an injection box (110) such that the fibrous material is partially impregnated and surrounded by the liquid resin component to form a resin-infused fibrous material. The resin-infused fibrous material is then introduced to a first die (130) and partially cured to form a partially-cured fiber-reinforced core material (80). The core material exits the first die to an intermediate region, where a polymer layer (40) is then applied onto at least a portion of the outer profile surface of the core material. The material then enters a second die (140), where the liquid resin component is fully cured to form a fiber-reinforced thermoset core material (30) having the polymer layer adhered thereon within the second die, thus forming the multi-layered structure (20).

Abstract: An aircraft emergency control system comprises at least one sensor configured to output an electronic signal relating to detection of incapacitation of at least one aircraft crew member. A processor is configured to receive and process the electronic signal to determine whether emergency action is to be taken. A control unit is configured to communicate, in use, a control signal to an avionics system of the aircraft in relation to the emergency action if the processor determines that emergency action is to be taken.

Abstract: There is a method for treating a psoriasis. A compound is administered in a therapeutically effective amount to a subject suffering therefrom. The compound has the structure or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof.

Abstract: An owner-tenant wireless shared omnibus access control system configured to enable owners and tenant users of an electronic access control system to seamlessly access a lock that is shared between remote site owners and one or more tenants, while maintaining access control and audit trail with minimal administrative overhead. An owner-tenant wireless shared omnibus access control system may be operably configured to enable expanded or limited access and audit trail information based on different user roles and permissions comprising an owner user and a tenant user.

Abstract: A smart sensor early warning notification system. Certain aspects of the present disclosure provide for a smart sensor early warning notification system comprising a smart sensor coupled to a door and configured to detect one or more unauthorized access events, including sawing, blunt force and other atypical vibrations to the door. A smart sensor may be communicably engaged with a local alarm to communicate sensor data received at the smart sensor. The local alarm may be configured to process the sensor data received from the smart sensor and trigger an alarm event and/or notification or pre-event detection alert in response to the sensor data. A door controller may be configured to send different pulses or messages to indicate the type of alarm event to an alarm management server and/or access control servers via public/private cloud.

Abstract: An integrated electronic locking system and electronic locking device configured to enable electronic access control of an integrated electronic locking device via multiple electronic access modalities across multiple user types/roles. An object of the present disclosure is an integrated electronic locking system configured to enable a system administrator to configure different access control parameters for two or more different access control modalities/types across two or more different users and/or use cases. In accordance with certain embodiments, an integrated electronic locking system comprises an integrated electronic locking device communicably engaged with a remote server over a wireless or wireline communications interface to enable one or more operations of an integrated electronic access control method.

Abstract: A facilities access breach detection and data protection system and method. A facilities access breach detection and data protection system and method may be configured to monitor an unauthorized access event at a secured data center facility via one or more breach detection sensors. A sensor input indicating a breach event may be communicated to an electronic access controller configured to process the sensor input. If the controller determines the sensor input indicates a breach event, the controller may be configured to communicate a command to a security server comprising erasure software stored thereon. The security server may be communicably engaged with a plurality of data servers housed at the data center facility. The security server may launch an instance of the erasure software to permanently erase all or part of the data residing on the plurality of data servers being housed at the data center facility.

Abstract: An integrated arc flash safety system and methods for remote access control and safety compliance. An electronic access control system may comprise an enclosure having a door, a door lock device, an electronic access control unit, and an arc sensor. The access controller comprises electronic hardware and software for sensor/detection operation, door lock device operation, door lock actuation, and wireless remote communication. The door lock device may be controlled by the access controller in combination with the arc sensor. The access controller may facilitate remote access control via a smart mobile computing device (e.g., mobile phone) and telecommunication with a remote cloud server via a communication network (e.g., Internet). Embodiments of the present disclosure enable rapid detection of an arc flash precondition or event within an enclosure and warning generation as well as protection and standard compliance measures to improve technician safety.

Abstract: A pressure monitoring system and method for warning a patient or caregiver that soft tissue pressure has exceeded some predetermined level that over time would necessitate moving the patient to prevent or at least reduce a risk of soft tissue damage. The pressure monitoring system and method utilize a dressing assembly adapted to be applied to or near a surface of the patient's body and generate electrical outputs corresponding to soft tissue pressure sensed at the surface. The dressing assembly includes a pocket formed therein for removable, secured and protected insertion of one or more sensors.

Abstract: A keyless puck lock apparatus with wireless communications and power interfaces. Embodiments of the present disclosure provide a keyless puck lock system enabling a low cost and high security solution that is difficult to tamper with and defeat. In the preferred embodiment of the present invention, the system uses a keyless puck lock assembly that includes a hasp assembly and a keyless lock mechanism that does not require any physical mechanical keys so that it does not have a mechanical cylinder inserted therein to lock or unlock the puck lock. Accordingly, the keyless puck lock system in accordance with one or more embodiments of the present invention does not have a physical keyway which is a security attack point that is included in conventional hockey puck-type locks.

Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Abstract: A multi-device electronic access control application, method and system. Certain aspects of the present disclosure provide for an end user mobile application that inter-operates with various types of electronic locking devices in a simple, repeatable method to enable a user to unlock any make or model of electronic access control device, if they are authorized to do so at that site, time and purpose, from a single mobile application user interface. An end user mobile application may be communicably engaged with a remote application server to integrate with enterprise backend user/site data and alarm systems, such that the end user mobile application is configured to manage user authorization/authentication, site access protocols/permissions and alarm management. An electronic access control method may comprise one or more steps for authorizing a user; suppressing an alarm; and unlocking an electronic locking device with a specified method for the given access point.

Abstract: A manufacturing method uses layered slabs to create a final pattern for a mold or for creating the mold itself. The method includes: preparing a desired number of slabs including a first slab and a second slab; machining the first slab; machining the second slab; and after the second slab is coupled to the first slab, repeating the machining step for each additional slab included in the desired number of slabs to form the final pattern or mold.

Abstract: An electronic straight shackle lock apparatus and system. Aspects of the present disclosure provide for a keyless, electronic straight shackle lock that provides a high level of security at a relatively low cost and without any opening for a physical mechanical key. Certain embodiments provide for an easy-to-use and compact adapter for a keyless, electronic straight shackle lock and the ability to manually override the electronic lock. Certain benefits and advantages of the present disclosure include a compact and flexible locking system that can be installed on many different enclosures and doors that can be locked and unlocked using an electronic device via a wireless signal.

Abstract: An electronic access control system and method that enables conditional access to electronic locking systems according to user-based and situation-based safety parameters. Aspects of the present disclosure provide for a mobile access interface whereby the network operations center can assess a safety risk for a service site based on a combination of user-generated inputs, sensor inputs and/or external data inputs. The system may comprise a dynamic rules engine configured to dynamically determine safety and compliance associated with an access-restricted area. If the access-restricted area is safe, the system may enable access according to one or more access protocols. If the access-restricted area is unsafe, or the user requesting access is not in compliance with one or more static or dynamic safety parameters, the system may disable standard access protocols and deny access to the requesting party.

Abstract: A dressing assembly for providing a warning to a patient or caregiver that the patient needs attention. The dressing assembly is adapted to be applied to or near a surface of the patient's body and generate electrical outputs corresponding to soft tissue pressure and other health characteristics sensed at the surface. The dressing assembly includes a pocket formed therein for removable, secured and protected insertion of a variety of different sensors such as multiple pressure sensors.

Abstract: Systems and methods are provided to re-authenticating an electronic device. The systems and methods (1) receive from an electronic device, a request to access a local access network on-board a vehicle, the request including a device identifier of the electronic device; (2) query, using the device identifier, an access profile assigned to the electronic device to determine that the electronic device has previously been authenticated during a first communication session, wherein the access profile is assigned to the electronic device based upon an indication of a user selection received from the electronic device; (3) monitor network usage associated with the electronic device during a second communication session; and (4) automatically re-authenticate the electronic device based on the monitoring.

Abstract: There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.