Patents by Inventor Matthew A. Holden
Matthew A. Holden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240070599Abstract: A network system provides delivery of items using unmanned aerial vehicles (UAV) or drones. The network system uses an infrastructure of nodes that include landing pads to dock drones, as well as interfaces to provide and receive items from docked drones. Nodes may be stationary (e.g., fixed at a building rooftop or public transit station) or mobile (e.g., mounted to a vehicle). The network system may determine a route for delivery of an item, where a drone transports the item for at least a portion of the route. For example, the route may include multiple waypoints associated with nodes between which drones travel. For other portions of the route, the network system may request a provider to transport the item using a ground-based vehicle.Type: ApplicationFiled: June 22, 2023Publication date: February 29, 2024Inventors: Matthew Sweeney, Nikhil Goel, Mark Moore, Jeffrey A. Holden
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Publication number: 20240027437Abstract: Droplet-interface bilayer and lipid bilayer membrane compositions stabilized with an amphiphilic polymer are disclosed. Methods of making and using the compositions are also disclosed.Type: ApplicationFiled: May 1, 2023Publication date: January 25, 2024Inventors: Matthew A. Holden, Max J. Lein, Arash Manafirad, Dan Ezra Aurian-Blajeni
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Publication number: 20230363459Abstract: An aerosol provision device is described. One such device comprises a first chassis and an aerosol generating assembly. The aerosol generating assembly includes a heater assembly for receiving an aerosol generating material. The heater assembly comprises a susceptor which is heatable by penetration with a varying magnetic field. The aerosol generating assembly also has a second chassis extending around the susceptor; and an inductor coil extending around the second chassis, wherein the inductor coil is configured to generate the varying magnetic field. The second chassis comprises a locating arrangement configured to locate the aerosol generating assembly on the first chassis.Type: ApplicationFiled: September 15, 2021Publication date: November 16, 2023Inventors: Jai TAANK, Michael THOMAS, Matthew HOLDEN, Conor MCGRATH
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Publication number: 20230354900Abstract: An aerosol provision device is described. The device comprises an aerosol generating assembly, an electrical component, which may be a printed circuit board (PCB) and a chassis holding the electrical component and the aerosol generating assembly. The aerosol generating assembly has: a heater assembly to receive aerosol generating material. The heater assembly has a susceptor which is heatable by penetration with a varying magnetic field; and an inductor coil extending around the heater assembly. The inductor coil generates the varying magnetic field. The inductor coil has a coil wire end engaged with the electrical component. The chassis has a coil end positioning arrangement to hold and align the coil wire end with the electrical component. The chassis itself is also described herein.Type: ApplicationFiled: September 15, 2021Publication date: November 9, 2023Inventors: Michael THOMAS, Matthew HOLDEN, Conor MCGRATH, Jonathan BURGESS
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Publication number: 20230309623Abstract: An aerosol provision device is described. One such device includes a heater assembly arranged to receive aerosol generating material. The heater assembly has a susceptor which is heatable by penetration with a varying magnetic field. A fluidly sealed enclosure extends around at least part of the heater assembly defining a fluidly sealed cavity between the enclosure and the susceptor. An inductor coil extends around the enclosure. The inductor coil generates the varying magnetic field.Type: ApplicationFiled: September 15, 2021Publication date: October 5, 2023Inventors: Michael THOMAS, Conor MCGRATH, Luke WARREN, David BUREAU, Jonathan BURGESS, Matthew HOLDEN, Jorge GOMEZ
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Patent number: 11756689Abstract: A method for simulating a deep-brain stimulation in a computer-assisted platform that includes providing to a neurosurgeon, through a man-machine interface, visual information of a pre-operative situation, including a representation of a brain. The method also includes monitoring inputs of said neurosurgeon on the man-machine interface, until a trajectory is determined between an entry point and a target for the placement of an electrode. The method further includes comparing said trajectory to a set of previously-established trajectories for the pre-operative situation, so as to determine an overall measurement representative of a quality of the trajectory compared to the previously-established trajectories.Type: GrantFiled: October 9, 2018Date of Patent: September 12, 2023Assignees: UNIVERSITÉ DE RENNES 1, INSERM—INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, CENTRE HOSPITALIER UNIVERSITAIRE PONTCHAILLOU, QUEEN'S UNIVERSITYInventors: Gabor Fichtinger, Matthew Holden, Pierre Jannin, Claire Haegelen, Yulong Zhao
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Publication number: 20230264164Abstract: Nucleic acid memory strands encoding digital data using a sequence of a homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.Type: ApplicationFiled: March 27, 2023Publication date: August 24, 2023Inventors: J. William Efcavitch, Sanjay Agarwalla, Kim Albizati, Alan Grubbs, Matthew Holden, Patrycja Hopkins, Jay Singh
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Patent number: 11674955Abstract: Droplet-interface bilayer and lipid bilayer membrane compositions stabilized with an amphiphilic polymer are disclosed. Methods of making and using the compositions are also disclosed.Type: GrantFiled: April 20, 2022Date of Patent: June 13, 2023Assignee: THE UNIVERSITY OF MASSACHUSETTSInventors: Matthew A. Holden, Max J. Lein, Arash Manafirad, Dan Ezra Aurian-Blajeni
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Publication number: 20230158503Abstract: Droplet interfaces are formed between droplets in an electro-wetting device comprising an array of actuation electrodes. Actuation signals are applied to selected actuation electrodes to place the droplets into an energised state in which the shape of the droplets is modified compared to a shape of the droplets in a lower energy state and to bring the two droplets into proximity. The actuation signals are then changed to lower the energy of the droplets into the lower energy state so that the droplets relax into the gap and the two droplets contact each other thereby forming a droplet interface. The use of sensing electrodes in the device permit electrical current measurements across the droplet interface. The sensing electrodes can be used for either (i) applying a reference signal during droplet actuation or (ii) recording electrical current measurements.Type: ApplicationFiled: November 18, 2022Publication date: May 25, 2023Applicants: Oxford Nanopore Technologies PLC, Sharp Life Science EU (Ltd)Inventors: Matthew Holden, James White, Andrew John Heron, James Anthony Clarke, Jason Robert Hyde, Benjamin James Hadwen, Sally Anderson
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Patent number: 11534763Abstract: Droplet interfaces are formed between droplets in an electro-wetting device comprising an array of actuation electrodes. Actuation signals are applied to selected actuation electrodes to place the droplets into an energised state in which the shape of the droplets is modified compared to a shape of the droplets in a lower energy state and to bring the two droplets into proximity. The actuation signals are then changed to lower the energy of the droplets into the lower energy state so that the droplets relax into the gap and the two droplets contact each other thereby forming a droplet interface. The use of sensing electrodes in the device permit electrical current measurements across the droplet interface. The sensing electrodes can be used for either (i) applying a reference signal during droplet actuation or (ii) recording electrical current measurements.Type: GrantFiled: December 21, 2018Date of Patent: December 27, 2022Assignees: Oxford Nanopore Technologies PLC, Sharp Life Science EU (Ltd)Inventors: Matthew Holden, James White, Andrew John Heron, James Anthony Clarke, Jason Robert Hyde, Benjamin James Hadwen, Sally Anderson
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Publication number: 20220390440Abstract: Droplet-interface bilayer and lipid bilayer membrane compositions stabilized with an amphiphilic polymer are disclosed. Methods of making and using the compositions are also disclosed.Type: ApplicationFiled: April 20, 2022Publication date: December 8, 2022Inventors: Matthew A. Holden, Max J. Lein, Arash Manafirad, Dan Ezra Aurian-Blajeni
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Patent number: 11340220Abstract: Droplet-interface bilayer and lipid bilayer membrane compositions stabilized with an amphiphilic polymer are disclosed. Methods of making and using the compositions are also disclosed.Type: GrantFiled: April 2, 2020Date of Patent: May 24, 2022Assignee: THE UNIVERSITY OF MASSACHUSETTSInventors: Matthew A. Holden, Max J. Lein, Arash Manafirad, Dan Ezra Aurian-Blajeni
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Publication number: 20220001386Abstract: The invention relates to a sensing system comprising an electrowetting device, which electrowetting device comprises an array of actuation electrodes, and a control system configures to perform droplet operations on a system of droplets present in the sensing system. The invention also relates to a method of operating the sensing system of the invention. The invention also provides novel droplet constructs which can be made and manipulated in the sensing system of the invention.Type: ApplicationFiled: November 28, 2019Publication date: January 6, 2022Applicant: Oxford Nanopore Technologies LimitedInventors: Matthew Holden, Andrew John Heron
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Publication number: 20210205814Abstract: Droplet interfaces are formed between droplets in an electro-wetting device comprising an array of actuation electrodes. Actuation signals are applied to selected actuation electrodes to place the droplets into an energised state in which the shape of the droplets is modified compared to a shape of the droplets in a lower energy state and to bring the two droplets into proximity. The actuation signals are then changed to lower the energy of the droplets into the lower energy state so that the droplets relax into the gap and the two droplets contact each other thereby forming a droplet interface. The use of sensing electrodes in the device permit electrical current measurements across the droplet interface. The sensing electrodes can be used for either (i) applying a reference signal during droplet actuation or (ii) recording electrical current measurements. Two or more electrodes are configurable to lyse cells within a droplet positioned over said electrodes.Type: ApplicationFiled: May 24, 2019Publication date: July 8, 2021Inventors: Matthew Holden, Ken Healy
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Publication number: 20210008557Abstract: Droplet interfaces are formed between droplets in an electro-wetting device comprising an array of actuation electrodes. Actuation signals are applied to selected actuation electrodes to place the droplets into an energised state in which the shape of the droplets is modified compared to a shape of the droplets in a lower energy state and to bring the two droplets into proximity. The actuation signals are then changed to lower the energy of the droplets into the lower energy state so that the droplets relax into the gap and the two droplets contact each other thereby forming a droplet interface. The use of sensing electrodes in the device permit electrical current measurements across the droplet interface. The sensing electrodes can be used for either (i) applying a reference signal during droplet actuation or (ii) recording electrical current measurements.Type: ApplicationFiled: December 21, 2018Publication date: January 14, 2021Applicants: Oxford Nanopore Technologies Ltd., Sharp Life Science (EU) LtdInventors: Matthew HOLDEN, James WHITE, Andrew John HERON, James Anthony CLARKE, Jason Robert HYDE, Benjamin James HADWEN, Sally ANDERSON
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Publication number: 20200335221Abstract: This invention relates to a method for simulating a deep-brain stimulation in a computer-assisted platform, comprising steps of: providing to a neurosurgeon, through a man-machine interface, visual information of a pre-operative situation, including a representation of a brain; monitoring inputs of said neurosurgeon on the man-machine interface, until a trajectory is determined between an entry point and a target for the placement of an electrode; comparing said trajectory to a set of previously-established trajectories for the pre-operative situation, so as to determine an overall measurement representative of a quality of the trajectory compared to the previously-established trajectories.Type: ApplicationFiled: October 9, 2018Publication date: October 22, 2020Inventors: Gabor FICHTINGER, Matthew HOLDEN, Pierre JANNIN, Claire HAEGELEN, Yulong ZHAO
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Publication number: 20200232980Abstract: Droplet-interface bilayer and lipid bilayer membrane compositions stabilized with an amphiphilic polymer are disclosed. Methods of making and using the compositions are also disclosed.Type: ApplicationFiled: April 2, 2020Publication date: July 23, 2020Inventors: Matthew A. Holden, Max J. Lein, Arash Manafirad, Dan Ezra Aurian-Blajeni
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Patent number: 10641764Abstract: Droplet-interface bilayer and lipid bilayer membrane compositions stabilized with an amphiphilic polymer are disclosed. Methods of making and using the compositions are also disclosed.Type: GrantFiled: July 1, 2016Date of Patent: May 5, 2020Assignee: THE UNIVERSITY OF MASSACHUSETTSInventors: Matthew A. Holden, Max J. Lein, Arash Manafirad, Dan Ezra Aurian-Blajeni
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Patent number: 10217650Abstract: A substrate cleaning apparatus may include a substrate support having a support surface to support a substrate to be cleaned, wherein the substrate support is rotatable about a central axis normal to the support surface; a first nozzle to provide a first cleaning gas to a region of the inner volume corresponding to the position of an edge of the substrate when the substrate is supported by the support surface of the substrate support; a first annular body disposed opposite and spaced apart from the support surface of the substrate support by a gap, the first annular body having a central opening defined by an inner wall shaped to provide a reducing size of the gap between the first annular body and the support surface in a radially outward direction; and a first gas inlet to provide a first gas to the central opening of the first annular body.Type: GrantFiled: September 13, 2016Date of Patent: February 26, 2019Assignee: APPLIED MATERIALS, INC.Inventors: James Matthew Holden, Song-Moon Suh, Todd Egan, Kalyanjit Ghosh, Leon Volfovski, Michael R. Rice, Richard Giljum
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Publication number: 20180196040Abstract: Droplet-interface bilayer and lipid bilayer membrane compositions stabilized with an amphiphilic polymer are disclosed. Methods of making and using the compositions are also disclosed.Type: ApplicationFiled: July 1, 2016Publication date: July 12, 2018Inventors: Matthew A. Holden, Max J. Lein, Arash Manafirad, Dan Ezra Aurian-Blajeni