Abstract: A computer-based method for determining an effect of operational readiness for a vehicle in a fleet of vehicles based on a component replacement simulation is described. The method includes querying, using a fleet performance optimization tool, a maintenance data database. The method also includes analyzing the data set using a power law process to predict a next component removal for each vehicle based on hours of operation for each vehicle. The method also includes determining an effect of operational readiness for the selected vehicle based on the simulation. The method further includes ranking each vehicle in the fleet of vehicles based on the operational readiness of each vehicle. The method also includes displaying, based on the ranking, the operational readiness of each vehicle on the user interface to facilitate actual replacement of at least one component on at least one of the vehicles.

Abstract: A surgical instrument for implanting a semi-rigid medical implant. The surgical instrument includes a shaft, an accessory shaft, an actuation mechanism and an implant engagement mechanism. The shaft has a channel formed therein. The shaft has a proximal end and a distal end. The accessory shaft is slidably mounted in the channel. The accessory shaft has a proximal end and a distal end. The actuation mechanism is mounted to the shaft proximate the proximal end thereof. The actuation mechanism is capable of causing the accessory shaft to slide with respect to the shaft. The implant engagement mechanism is attached to the distal end of the accessory shaft. The implant engagement mechanism is capable of engaging a semi-rigid surgical implant.

Abstract: A method for performing Photon Counting Computed Tomography (PCCT) using a combination of contrast agents includes configuring a PCCT device with a plurality of threshold values corresponding to a plurality of contrast agents. These contrast agents comprise a long-acting blood pool contrast agent and a nanoparticle contrast agent. The PCCT device is used to perform an imaging scan on an anatomical subject in the presence of the plurality of contrast agents to acquire image data. Next, the imaging data is processed into a plurality of datasets based on the plurality of threshold values. The datasets comprise a first dataset corresponding to the long-acting blood pool contrast agent, and a second dataset corresponding to the nanoparticle contrast agent.

Abstract: A Dye Sensitized Photoelectrosynthesis Cell (DSPEC) splits water with visible light using a derivatized, core/shell nanostructured photoanode with the core having a high surface area conductive metal oxide film—such as nanoITO (indium tin oxide) or nanoATO (antimony tin oxide)—coated with a thin outer shell of, for example, TiO2 formed by Atomic Layer Deposition (ALD). A “chromophore-catalyst assembly” 1, [(PO3H2)2bpy)2Ru(4-Mebpy-4-bimpy)Ru(tpy)(OH2)]4+, which combines both light absorber and water oxidation catalyst in a single molecule, is attached to the TiO2 shell. Visible photolysis of the resulting core/shell/assembly structure with a Pt cathode results in water splitting into hydrogen and oxygen.

Abstract: Disclosed herein are analogues of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors. The compounds are expected to be useful in the treatment of cancer, particularly cancers that are dependent upon the hedgehog signaling pathway such as basal cell carcinoma and medulloblastoma.

Abstract: Disclosed herein are analogues of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors. The compounds are expected to be useful in the treatment of cancer, particularly cancers that are dependent upon the hedgehog signaling pathway such as basal cell carcinoma and medulloblastoma.

Abstract: Disclosed herein are analogs of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors. The compounds are expected to be useful in the treatment of cancer, particularly cancers that are dependent upon the hedgehog signaling pathway such as basal cell carcinoma and medulloblastoma.

Abstract: A method for performing Photon Counting Computed Tomography (PCCT) using a combination of contrast agents includes configuring a PCCT device with a plurality of threshold values corresponding to a plurality of contrast agents. These contrast agents comprise a long-acting blood pool contrast agent and a nanoparticle contrast agent. The PCCT device is used to perform an imaging scan on an anatomical subject in the presence of the plurality of contrast agents to acquire image data. Next, the imaging data is processed into a plurality of datasets based on the plurality of threshold values. The datasets comprise a first dataset corresponding to the long-acting blood pool contrast agent, and a second dataset corresponding to the nanoparticle contrast agent.

Abstract: Disclosed herein are analogues of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors. The compounds are expected to be useful in the treatment of cancer, particularly cancers that are dependent upon the hedgehog signaling pathway such as basal cell carcinoma and medulloblastoma.

Abstract: A bottom hole assembly comprises a milling tool and associated drive motor with a shifting tool that is capable on deployment to selectively grab, shift and release from sliding sleeves when the bottom hole assembly is removed from the subterranean location. The shifting tool is preferably protected from the returning flow of cuttings to avoid erosion or clogging from the cuttings being circulated to the surface. The shifter tool can be of a known design to enable the milling of ball seats or entire plugs in the same trip as the operation of the sliding sleeve valves associated with the treatment operation so that the well can then be in position to commence production or injection once a suitable string and service packer are set in position. Typically the sleeves are open for the treatment and then closed after milling as the bottom hole assembly is removed.

Abstract: A wagering game includes a display assembly having a touch-sensitive display adjacent to or overlaying a display area operable to present a wagering game presentation. The touch-sensitive display is operable to display a residual graphic effect such as a trailing particle effect following the path of a player's finger or other contactor in contact with the touch-sensitive display. The residual graphic effect may include repeated discrete graphic elements such as a star or sparkle, or a game theme-associated element such as a butterfly or butterflies corresponding to a butterfly themed game. The residual graphic effect may also or alternatively include an effect such as a wave or ripple visual effect or a shockwave visual effect which does not necessarily include any discrete graphic element.

Abstract: A Dye Sensitized Photoelectrosynthesis Cell (DSPEC) splits water with visible light using a derivatized, core/shell nanostructured photoanode with the core having a high surface area conductive metal oxide film—such as nanoITO (indium tin oxide) or nanoATO (antimony tin oxide)—coated with a thin outer shell of, for example, TiO2 formed by Atomic Layer Deposition (ALD). A “chromophore-catalyst assembly” 1, [(PO3H2)2bpy)2Ru(4-Mebpy-4-bimpy)Ru(tpy)(OH2)]4+, which combines both light absorber and water oxidation catalyst in a single molecule, is attached to the TiO2 shell. Visible photolysis of the resulting core/shell/assembly structure with a Pt cathode results in water splitting into hydrogen and oxygen.

Abstract: Implantable biomedical device leads comprising liquid conductors. In an exemplary embodiment of a lead for use in a biomedical application of the present disclosure, the lead comprises a lead body having a distal end and a proximal end, the lead body defining a first interior lumen therethrough, and an electrically conductive composition positioned within the first interior lumen, the electrically conductive composition comprising a metal in a liquid state at or below about 98° F. In another embodiment, the electrically conductive composition is selected from the group consisting of gallium, a gallium-indium alloy, Galinstan, its/their alloys, and combinations thereof. In various embodiments, the metallic electrically conductive composition is used along with a second non-metallic electrically conductive composition such as a conductive polymer, an electrically conductive liquid, an electrically conductive gel, or combinations thereof.

Abstract: A wagering game includes a display assembly having a touch-sensitive display adjacent to or overlaying a display area operable to present a wagering game presentation. The touch-sensitive display is operable to display a residual graphic effect such as a trailing particle effect following the path of a player's finger or other contactor in contact with the touch-sensitive display. The residual graphic effect may include repeated discrete graphic elements such as a star or sparkle, or a game theme-associated element such as a butterfly or butterflies corresponding to a butterfly themed game. The residual graphic effect may also or alternatively include an effect such as a wave or ripple visual effect or a shockwave visual effect which does not necessarily include any discrete graphic element.

Abstract: A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.

Abstract: A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.

Abstract: A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.

Abstract: A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.