Abstract: A quick disconnect coupling for an access valve is disclosed which includes a housing having an independently displaced depressor mounted within the housing, a sliding sleeve mounted on one end of the housing, ball bearings retained in the housing between ball bearing cavities and the sliding sleeve, and locking means preventing the removal of the quick disconnect coupling from the access valve unless the depressor is withdrawn to seal off flow from both the valve and the quick disconnect coupling. The quick disconnect coupling can thus be attached to a valve without establishing communication therethrough or through the quick disconnect coupling until the depressor mounted within the housing is independently moved into contact with the core of the access valve.