Abstract: A barbed suture including a body with barbs on the periphery, a pointed end, and an anchor at one end to resist movement of the suture in the direction of the pointed end is provided. One or more limbs on the anchor may be provided, which may be arcuate, of varying lengths, and of varying distribution about the periphery of the suture body. Other anchor designs are provided. Methods of placing single-directional and bi-directional barbed sutures to approximate the tissue on each side of a wound and to position and support tissue in the absence of a wound, as in cosmetic surgery, are provided, and may include terminal J-stitches or S-stitches. Methods of placement may be made with sharp, pointed ends, which may be needles, or insertion devices. Sinusoidal patterns of sutures that have amplitudes generally perpendicular to the resultant holding force of the suture are provided.

Abstract: Systems and methods are described for integrating one or more machine learning models with a client application using Remote Procedure Calls (RPCs). A server deploys a software container associated with a client application, the container comprising executable code corresponding to a machine learning model, a plurality of inputs to the machine learning model, and a plurality of outputs of the machine learning model. The server generates a protocol buffer profile using the inputs and the outputs, the protocol buffer profile defining RPC functions for integrating the client application and the machine learning model. The server receives, from the client application, a request to access the machine learning model using a first RPC function. The server executes the machine learning model to generate a classification value for input provided in the request. The server transmits the classification value to the client application using a second RPC function.

Abstract: A method and device for anchoring a length of self-retaining suture. The method of anchoring includes providing for an assembly having a length of self-retaining suture and a suture insertion device. The length of suture includes at least a portion of the length having a plurality of retainers thereon extending in a first direction. The insertion device has a length and a recess to receive a portion of the suture length. The method further includes placing a portion of the suture length in the recess and inserting the device into the body of a mammal until the recess reaches a predetermined location thereby forming an insertion pathway. The method further includes retrieving the insertion device from the body by moving the insertion device in a direction substantially opposed to the insertion pathway.

Abstract: A fluid transfer assembly comprises a housing for accommodating a fluid. A bellows member disposed in the housing defines an opening therethrough adapted to be in fluid communication with an applicator assembly. The bellows member is adapted to operatively engage the applicator assembly for extension in a first direction and contraction in a second direction. The bellows member seals against the inner surface of the housing during extension and contraction for defining a variable volume chamber with the housing. Expansion of the bellows member in the first direction reduces the chamber volume for generating positive pressure in the housing and forcing fluid through a valve to the applicator assembly. Contraction of the bellows member in the second direction increases the chamber volume for generating negative pressure within the housing for drawing fluid into the chamber.

Abstract: A method and device for anchoring a length of self-retaining suture. The method of anchoring includes providing for an assembly having a length of self-retaining suture and a suture insertion device. The length of suture includes at least a portion of the length having a plurality of retainers thereon extending in a first direction. The insertion device has a length and a recess to receive a portion of the suture length. The method further includes placing a portion of the suture length in the recess and inserting the device into the body of a mammal until the recess reaches a predetermined location thereby forming an insertion pathway. The method further includes retrieving the insertion device from the body by moving the insertion device in a direction substantially opposed to the insertion pathway.

Abstract: An apparatus for dispensing a fluid from a source of fluid comprises a roller and a tray member. The tray member comprises a pair of spaced walls having a contiguous tapered inner surface for defining an arcuate recess in an outer surface of the tray member, the outer surface tapering to an outer edge of each wall. Roller mounting means includes a pair of resilient spaced arms, each one of the arms spanning between and interconnecting the ends of the spaced wall. The tray member defines a pair ports spaced along a central longitudinal axis of the tray member for providing fluid communication between the source of fluid and the tray member. The roller is rotatably mounted to the spaced arms for receiving fluid from the tray member and applying the fluid onto a surface.

Abstract: A barbed suture including a body with barbs on the periphery, a pointed end, and an anchor at one end to resist movement of the suture in the direction of the pointed end is provided. One or more limbs on the anchor may be provided, which may be arcuate, of varying lengths, and of varying distribution about the periphery of the suture body. Other anchor designs are provided. Methods of placing single-directional and bi-directional barbed sutures to approximate the tissue on each side of a wound and to position and support tissue in the absence of a wound, as in cosmetic surgery, are provided, and may include terminal J-stitches or S-stitches. Methods of placement may be made with sharp, pointed ends, which may be needles, or Insertion devices. Sinusoidal patterns of sutures that have amplitudes generally perpendicular to the resultant holding force of the suture are provided.

Abstract: A barbed suture including a body with barbs on the periphery, a pointed end, and an anchor at one end to resist movement of the suture in the direction of the pointed end is provided. One or more limbs on the anchor may be provided, which may be arcuate, of varying lengths, and of varying distribution about the periphery of the suture body. Other anchor designs are provided. Methods of placing single-directional and bi-directional barbed sutures to approximate the tissue on each side of a wound and to position and support tissue in the absence of a wound, as in cosmetic surgery, are provided, and may include terminal J-stitches or S-stitches. Methods of placement may be made with sharp, pointed ends, which may be needles, or insertion devices. Sinusoidal patterns of sutures that have amplitudes generally perpendicular to the resultant holding force of the suture are provided.

Abstract: A method and device for anchoring a length of self-retaining suture. The method of anchoring includes providing for an assembly having a length of self-retaining suture and a suture insertion device. The length of suture includes at least a portion of the length having a plurality of retainers thereon extending in a first direction. The insertion device has a length and a recess to receive a portion of the suture length. The method further includes placing a portion of the suture length in the recess and inserting the device into the body of a mammal until the recess reaches a predetermined location thereby forming an insertion pathway. The method further includes retrieving the insertion device from the body by moving the insertion device in a direction substantially opposed to the insertion pathway.

Abstract: A barbed suture including a body with barbs on the periphery, a pointed end, and an anchor at one end to resist movement of the suture in the direction of the pointed end is provided. One or more limbs on the anchor may be provided, which may be arcuate, of varying lengths, and of varying distribution about the periphery of the suture body. Other anchor designs are provided. Methods of placing single-directional and bi-directional barbed sutures to approximate the tissue on each side of a wound and to position and support tissue in the absence of a wound, as in cosmetic surgery, are provided, and may include terminal J-stitches or S-stitches. Methods of placement may be made with sharp, pointed ends, which may be needles, or insertion devices. Sinusoidal patterns of sutures that have amplitudes generally perpendicular to the resultant holding force of the suture are provided.

Abstract: A fluid transfer assembly comprises a housing for accommodating a fluid. A bellows member disposed in the housing defines an opening therethrough adapted to be in fluid communication with an applicator assembly. The bellows member is adapted to operatively engage the applicator assembly for extension in a first direction and contraction in a second direction. The bellows member seals against the inner surface of the housing during extension and contraction for defining a variable volume chamber with the housing. Expansion of the bellows member in the first direction reduces the chamber volume for generating positive pressure in the housing and forcing fluid through a valve to the applicator assembly. Contraction of the bellows member in the second direction increases the chamber volume for generating negative pressure within the housing for drawing fluid into the chamber.

Abstract: A method and device for anchoring a length of self-retaining suture. The method of anchoring includes providing for an assembly having a length of self-retaining suture and a suture insertion device. The length of suture includes at least a portion of the length having a plurality of retainers thereon extending in a first direction. The insertion device has a length and a recess to receive a portion of the suture length. The method further includes placing a portion of the suture length in the recess and inserting the device into the body of a mammal until the recess reaches a predetermined location thereby forming an insertion pathway. The method further includes retrieving the insertion device from the body by moving the insertion device in a direction substantially opposed to the insertion pathway.

Abstract: A fluid transfer assembly comprises a housing for accommodating a fluid. A bellows member disposed in the housing defines an opening therethrough adapted to be in fluid communication with an applicator assembly. The bellows member is adapted to operatively engage the applicator assembly for extension in a first direction and contraction in a second direction. The bellows member seals against the inner surface of the housing during extension and contraction for defining a variable volume chamber with the housing. Expansion of the bellows member in the first direction reduces the chamber volume for generating positive pressure in the housing and forcing fluid through a valve to the applicator assembly. Contraction of the bellows member in the second direction increases the chamber volume for generating negative pressure within the housing for drawing fluid into the chamber.

Abstract: An apparatus for dispensing a fluid from a source of fluid comprises a roller and a tray member. The tray member comprises a pair of spaced walls having a contiguous tapered inner surface for defining an arcuate recess in an outer surface of the tray member, the outer surface tapering to an outer edge of each wall. Roller mounting means includes a pair of resilient spaced arms, each one of the arms spanning between and interconnecting the ends of the spaced wall. The tray member defines a pair ports spaced along a central longitudinal axis of the tray member for providing fluid communication between the source of fluid and the tray member. The roller is rotatably mounted to the spaced arms for receiving fluid from the tray member and applying the fluid onto a surface.

Abstract: An apparatus for dispensing a fluid from a source of fluid comprises a roller and a tray member. The tray member comprises a pair of spaced walls having a contiguous tapered inner surface for defining an arcuate recess in an outer surface of the tray member, the outer surface tapering to an outer edge of each wall. Roller mounting means includes a pair of resilient spaced arms, each one of the arms spanning between and interconnecting the ends of the spaced wall. The tray member defines a pair ports spaced along a central longitudinal axis of the tray member for providing fluid communication between the source of fluid and the tray member. The roller is rotatably mounted to the spaced arms for receiving fluid from the tray member and applying the fluid onto a surface.

Abstract: A barbed suture including a body with barbs on the periphery, a pointed end, and an anchor at one end to resist movement of the suture in the direction of the pointed end is provided. One or more limbs on the anchor may be provided, which may be arcuate, of varying lengths, and of varying distribution about the periphery of the suture body. Other anchor designs are provided. Methods of placing single-directional and bi-directional barbed sutures to approximate the tissue on each side of a wound and to position and support tissue in the absence of a wound, as in cosmetic surgery, are provided, and may include terminal J-stitches or S-stitches. Methods of placement may be made with sharp, pointed ends, which may be needles, or insertion devices. Sinusoidal patterns of sutures that have amplitudes generally perpendicular to the resultant holding force of the suture are provided.

Abstract: An apparatus for dispensing a fluid comprises a housing and a resilient liner adapted to hold the fluid disposed in the housing. A fluid transfer mechanism is in fluid communication between the liner and an applicator assembly mounted on the housing for dispensing the fluid on the skin of the user. The applicator assembly includes an actuator movable relative to the housing so as to activate the fluid transfer mechanism when the actuator is reciprocated. A fluid delivery element is held in contact against skin of a user for applying the fluid onto the skin. The fluid delivery element is supported on the actuator to be movable together with the actuator by varying contact pressure with the skin. Each movement of the actuator generates continuous negative pressure within the liner for drawing fluid through the fluid transfer mechanism and collapsing the liner.

Abstract: An apparatus for dispensing a fluid comprises a housing and a resilient liner adapted to hold the fluid disposed in the housing. A fluid transfer mechanism is in fluid communication between the liner and an applicator assembly mounted on the housing for dispensing the fluid on the skin of the user. The applicator assembly includes an actuator movable relative to the housing so as to activate the fluid transfer mechanism when the actuator is reciprocated. A fluid delivery element is held in contact against skin of a user for applying the fluid onto the skin. The fluid delivery element is supported on the actuator to be movable together with the actuator by varying contact pressure with the skin. Each movement of the actuator generates continuous negative pressure within the liner for drawing fluid through the fluid transfer mechanism and collapsing the liner.

Abstract: An apparatus for dispensing a fluid from a source of fluid comprises a roller and a tray member. The tray member comprises a pair of spaced walls having a contiguous tapered inner surface for defining an arcuate recess in an outer surface of the tray member, the outer surface tapering to an outer edge of each wall. Roller mounting means includes a pair of resilient spaced arms, each one of the arms spanning between and interconnecting the ends of the spaced wall. The tray member defines a pair ports spaced along a central longitudinal axis of the tray member for providing fluid communication between the source of fluid and the tray member. The roller is rotatably mounted to the spaced arms for receiving fluid from the tray member and applying the fluid onto a surface.

Abstract: A fluid transfer assembly comprises a housing for accommodating a fluid. A bellows member disposed in the housing defines an opening therethrough adapted to be in fluid communication with an applicator assembly. The bellows member is adapted to operatively engage the applicator assembly for extension in a first direction and contraction in a second direction. The bellows member seals against the inner surface of the housing during extension and contraction for defining a variable volume chamber with the housing. Expansion of the bellows member in the first direction reduces the chamber volume for generating positive pressure in the housing and forcing fluid through a valve to the applicator assembly. Contraction of the bellows member in the second direction increases the chamber volume for generating negative pressure within the housing for drawing fluid into the chamber.