Abstract: A circular saw plunge pipe cutter includes a main housing, a drive mechanism at least partially disposed within the main housing, a saw blade operably coupled with the drive mechanism, and a shoe slidably coupled to the main housing. The shoe includes a pipe receptacle in which a pipe is receivable. The circular saw plunge pipe cutter is adjustable between a plunge state, in which the main housing moves toward the shoe and the saw blade extends into the pipe receptacle, and a retracted state in which the main housing moves away from the shoe and the saw blade does not extend into the pipe receptacle.

Abstract: Systems and methods for generating dynamic quick actions for an application in a web browser. The dynamic quick actions correspond to various functions of an application accessible via a web browser sidebar interface. When a hover event is detected in association with an icon of the application, a quick-actions card is generated that includes quick actions of the application from which the user can select. For instance, a selection of a quick action triggers the web browser to execute an action that causes the application function to be performed. Thus, application functions are able to be surfaced and controlled via a single input device selection (e.g., a mouse click).

Abstract: A connector apparatus includes a housing and a locking mechanism. The locking mechanism includes a rotatable disc that cooperates with the housing to selectively secure a connector therewith. The locking mechanism also includes a first pawl and a second pawl configured to engage with the disc and at least one lock lever configured to engage with the disc. A first connector is secured to the housing via the disc engaging the pawls and the lock lever thereby rotationally locking the disc. A second connector actuates the pawls to disengage the disc and the lock lever is manually actuated to disengage the disc so that the first connector can be released while simultaneously securing the second connector to the housing.

Abstract: Certain aspects of the present disclosure include compounds having Formula (X). Disclosed embodiments also include compositions comprising at least one compound according to the present disclosure, such as from 5% to 70% of at least one compound according to the present disclosure, at a dosage of from 0.1 mg to about 10,000 mg, and further comprising an excipient, an adjuvant, a carrier, and/or at least one additional biologically active compound other than a compound according to the present disclosure. Disclosed compounds and/or can be administered to a subject multiple times per day, such as 1 to 3 times per day, and/or periodically, such as every 2 to 7 days, for a variety of reasons, such as to increase neuronal plasticity, to treat a neurological disease, to treat a neuropsychiatric disease, to elicit a biological response, such as by activating a 5-HT2A receptor, or to increase at least one of translation, transcription, or secretion of neurotrophic factors.

Abstract: Systems and methods for automated path-based recommendation for risk mitigation are provided. An entity assessment server, responsive to a request for a recommendation for modifying a current risk assessment score of an entity to a target risk assessment score, accesses an input attribute vector for the entity and clusters of entities defined by historical attribute vectors. The entity assessment server assigns the input attribute vector to a particular cluster and determines a requirement on movement from a first point to a second point in a multi-dimensional space based on the statistics computed from the particular cluster. The first point corresponds to the current risk assessment score and the second point corresponds to the target risk assessment score. The entity assessment server computes an attribute-change vector so that a path defined by the attribute-change vector complies with the requirement and generates the recommendation from the attribute-change vector.

Abstract: A droplet delivery device includes a droplets outlet coupled to a one-piece and removable container assembly, wherein the container assembly includes a mesh and a membrane, and wherein the mesh includes a plurality of openings formed through the mesh's thickness, a reservoir in fluid communication with the container assembly and configured to supply a volume of fluid, and a vibrating member coupled to a power source and positioned to cooperate with the membrane and mesh to generate an ejected stream of droplets through the mesh.

Abstract: A computer accesses a first symbolic expression for an output matrix as a function of an input matrix at a computing device comprising processing circuitry and memory. The computer computes a first Jacobian of the input matrix with respect to an input tangent space. The computer computes a second Jacobian of the output matrix with respect to the input matrix. The computer computes a third Jacobian of an output tangent space with respect to the input matrix. The computer applies symbolic matrix multiplication to the first Jacobian, the second Jacobian, and the third Jacobian to obtain a second symbolic expression for the output tangent space with respect to the input tangent space. The computer provides a representation of the second symbolic expression, the second symbolic expression representing a computed tangent-space Jacobian.

Abstract: Information characterizing a security event is received from an agent executing on an endpoint computing device. The received information identifies a plurality of files encrypted as part of a ransomware attack and key material used when encrypting each of the files. Based on the received information, a surveyor package is generated which includes decryptor logic to decrypt at least a portion of the files. The surveyor package is deployed to the agent so that it can be unpacked and executed to decrypt at least a portion of the files. Once these files are decrypted, then can be transported to a safe computing environment Related apparatus, systems, techniques and articles are also described.

Abstract: Methods and compositions for treating cholangiocarcinoma.

Abstract: The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 may optionally be substituted; and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: Methods, systems, and computer storage media for providing observation stream data of security incidents using an observation stream engine in a security management system. An observation stream framework supports continuously generating and presenting observation stream data that facilitates developing a working hypothesis of an active security incident. The observation stream framework can also include observation stream query-types that can be selected for running queries against a plurality of security data sources. In operation, an observation stream query is accessed. The observation stream query is a user-generated observation stream query associated with an observation stream query-type. The observation stream query-type comprises parameters for querying a plurality of security data sources and dynamic tracking of a security incident. The observation stream query is executed and observation stream data is generated.

Abstract: The subject technology receives, by one or more hardware processors implementing a local wireless network, a request from a client device to mirror media content displayed on a screen of the client device on a wearable device. In response to the request, the subject technology causes a display of the media content in a mirroring lens of the wearable device. While the media content is being displayed in the mirroring lens of the wearable device, the subject technology tracks hand gestures of a user wearing the wearable device and viewing the media content displayed in the mirroring lens of the wearable device. The subject technology processes navigational or manipulation data based on the tracked hand gestures and sends a navigation or manipulation instruction to the client device or a mirroring lens processor of the wearable device based on the tracked hand gestures.

Abstract: According to an aspect of the present invention, there is provided a pickleball paddle, comprising: carbon fiber, wherein the carbon fiber forms a single body head and handle; and a foam piece covering the carbon fiber handle, wherein: the carbon fiber runs to the edges of the head; and rubberized paint is applied to the edges of the carbon fiber head to define the boundaries of the paddle.

Abstract: The Use Determination Risk Coverage Datastructure for On-Demand and Increased Efficiency Coverage Detection and Rebalancing Apparatuses, Processes and Systems (“UDRCD”) transforms coverage enrollment request, event signal, ACGG request, search request, props ratios calculation request, encounters build request, episodes build request, price calculation request, price range generation request, price range lookup request inputs via UDRCD components into coverage enrollment response, add-in recommendation, ACGG response, search response, props ratios calculation response, encounters build response, episodes build response, price calculation response, price range generation resp., price range lookup resp. outputs. An episodes build request datastructure identifying an encounter type is obtained. An anchor encounter datastructure is selected. A set of other encounter datastructures for the anchor encounter datastructure is determined.

Abstract: Provided are systems and methods for capturing outcome information associated with various cancer treatments. The system facilitates capture and analysis of cancer treatment information and associated outcome information. The treatment and outcome information can include genomic analysis and information on treatment of different cancers. The system can store and analyze any one or more of: tumor type, genomic alterations (e.g., genes and associated alterations, gene sequence mutations, alterations, amplifications, deletions, etc.), and treatment data (including, for example, treatments targeted to specific genes and/or genomic alterations). Users of the outcome system can supply and use the treatment and outcome information to facilitate diagnosis and therapy decisions. User interfaces within the system can be configured to allow users to easily locate outcome information associated with particular treatments of tumors having certain genomic alterations.

Abstract: Systems and methods for managing multi-objective alignments in imprinting (e.g., single-sided or double-sided) are provided. An example system includes rollers for moving a template roll, a stage for holding a substrate, a dispenser for dispensing resist on the substrate, a light source for curing the resist to form an imprint on the substrate when a template of the template roll is pressed into the resist on the substrate, a first inspection system for registering a fiducial mark of the template to determine a template offset, a second inspection system for registering the imprint on the substrate to determine a wafer registration offset between a target location and an actual location of the imprint, and a controller for controlling to move the substrate with the resist below the template based on the template offset, and determine an overlay bias of the imprint on the substrate based on the wafer registration offset.

Abstract: This disclosure relates to a method of identifying or producing an aptamer capable of binding to at least two target analyte variants, the method comprises generating a mixture of systematic evolution of ligands by exponential enrichment (SELEX)-selected aptamers by at least one-round of SELEX with a SELEX-compatible aptamer pool against the at least two target analyte variants in parallel or sequentially, sequencing the mixture of SELEX-selected aptamers that form complexes with each of the at least two target analyte variants by high-throughput sequencing, aligning the mixture of SELEX-selected aptamers that form complexes with each of the at least two target analyte variants by sequence alignment analysis, and identifying or producing the aptamer capable of binding to the at least two target analyte variants. Aptamers thereof and uses of the aptamers thereof are also disclosed.

Abstract: A focal plane array includes a mosaic integrated circuit device having a plurality of discrete integrated circuit tiles mounted on a motherboard. The focal plane array includes an optically continuous detector array electrically connected to the mosaic integrated circuit device with an interposer disposed therebetween. The interposer is configured to adjust a pitch of the continuous detector array to match a pitch of each of the plurality of discrete integrated circuit tiles so that the optical gaps between each of the plurality of integrated circuit tiles on the motherboard are minimized and the detector array is optically continuous, having high yield over the large format focal plane array.