Abstract: A perforation system for accessing a location in or near a patient's heart is disclosed. The system includes a puncture device having a proximal portion and a distal portion including a distal tip. The system further includes an elongated introducer defining a lumen adapted to receive and allow longitudinal translation of the puncture device therein, the elongated introducer having an introducer proximal portion and an introducer distal portion, the introducer proximal portion including a locking hub. The locking hub includes a slot and an engaging surface configured so that the proximal portion can be positioned in the slot and against the engaging surface, so as to generate a securing frictional force between the proximal portion and the engaging surface, the securing friction force sufficient to inhibit the longitudinal translation of the puncture device with respect to the elongated introducer.

Abstract: System and method for de-centralized handling of high risk actions across coordinated systems. A monitoring system is used as an action advisor for performing the high risk actions at nodes across coordinated systems. The monitoring system advises performing the actions based on one or more monitoring signals corresponding to the coordinated systems. The process for performing the high risk actions is de-centralized. A metadata substrate system acts as a message broker between the monitoring system and coordinated systems.

Abstract: The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 and R3 are each independently hydrogen or an optionally substituted hydrocarbyl group, or R1 and R3 together with the nitrogen atom to which they are attached may form a 3- to 12-membered optionally substituted cyclic group; and R2 is a cyclic group substituted at the position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: In some implementations, a weather sensing device may include an optical sensor having an optical transmitter and an optical receiver disposed within a housing to sense atmospheric visibility. In addition, the device may include a first plate disposed on the housing in front of the optical transmitter and having a first aperture. The device may include a second plate disposed on the housing in front of the optical receiver and having a second aperture, where the first plate and second plate are arranged such that one of the plates is mounted on the housing above the other one of the plates edgewise in a vertical dimension. Moreover, the device may include a three dimensional corrugated structure disposed between the first and second apertures to reduce or eliminate optical coupling between the optical transmitter and the optical receiver.

Abstract: Systems and methods for generating dynamic quick actions for an application in a web browser. The dynamic quick actions correspond to various functions of an application accessible via a web browser sidebar interface. When a hover event is detected in association with an icon of the application, a quick-actions card is generated that includes quick actions of the application from which the user can select. For instance, a selection of a quick action triggers the web browser to execute an action that causes the application function to be performed. Thus, application functions are able to be surfaced and controlled via a single input device selection (e.g., a mouse click).

Abstract: An embodiment includes a method of real-time, endpoint-specific SLA compliance evaluation in a managed network. The method includes receiving SLA definition input that indicates an SLA definition of the managed network. Responsive to detection of a trigger event, the method includes initiating a scan of endpoints including retrieval of endpoint-level state data. The method includes identifying a portion of the retrieved state data relevant to the SLA definition. The method includes aggregating the portions of the retrieved state data. The method includes determining whether the managed network is SLA compliant at an endpoint-level of granularity based on the aggregated portions. Responsive to the managed network being noncompliant, the method includes identifying a subset of endpoints failing to meet the SLA definition and implementing a product modification process to address a metric of the SLA definition and change a product to bring the first endpoint into compliance.

Abstract: The present invention relates to compounds of formula (I): (I) wherein Q is selected from O or S; R1 is an optionally substituted hydrocarbyl group which may optionally include one or more heteroatoms N, O or S in its carbon skeleton, provided that the hydrocarbyl group includes at least one heteroatom N, O or S in its carbon skeleton or is substituted with a substituent comprising at least one heteroatom N, O or S, and provided that the atom of R1 which is attached to the sulfur atom of the remainder of the molecule is not a ring atom of a cyclic group; R2 is an ?,??-substituted cyclic group which may optionally be further substituted; R3 and R4 are each independently hydrogen, halogen, —OH, —NH2, —CN, —R5, —OR5, —NHRs or —N(R5)2; or R3 and R4 together with the carbon atom to which they are attached may form a 3- to 7-membered saturated or unsaturated, optionally substituted cyclic group; and R5 is independently optionally substituted C1-C4 alkyl.

Abstract: A radiofrequency guidewire is disclosed. The system includes a core wire having a tapered section, a first insulator portion having a first insulator property and a first insulator length, and a second insulator portion having a second insulator property and a second insulator length. The first insulator portion and the second insulator portion are positioned along the core wire so as to form an overlap portion aligned with the tapered section of the core wire.

Abstract: Systems, methods, and apparatuses for aggregating merchant offers include a network interface structured to facilitate data communication via a network, an accounts database structured to store account information associated with accounts held by the provider, including a payment account associated with a customer, and a processing circuit comprising a processor and memory. The processing circuit is structured to receive a pre-filtered offer from an offer vendor, aggregate the pre-filtered offer with other received pre-filtered offers from multiple offer vendors to create an aggregated offer list, filter the aggregated offer list based on the account information for the customer to create a filtered offer list, generate a prioritized offer list based on the account information for the customer, and transmit the prioritized offer list to a customer device of the customer.

Abstract: A radiofrequency perforation device is disclosed. The device includes an elongate member defining a lumen and extending from a proximal portion including a hub to a distal portion including a distal tip electrode having a distal face defining a distal opening and a slot. The device also includes an outer insulation layer covering a portion of an outer surface of the elongate member and leaving the distal tip electrode uncovered. Finally, the device includes an inner insulation layer covering at least the distal portion of the lumen.

Abstract: Hoses include an inner tube, a reinforcement layer disposed outwardly from the inner tube, and a cover layer disposed outwardly from the reinforcement layer, where the cover layer and/or the inner tube include(s) a composition having a sustainable content. The composition includes one or more ethylene based sustainable polymers. The one or more ethylene based sustainable polymers is formed of ethylene monomer derived from one or more renewable sources. The one or more ethylene based sustainable polymers may be one or more of PVC sustainable polymer, EPDM sustainable polymer and EPR sustainable polymer.

Abstract: Some protocols herein implement a first separation between first and second hybrid biochar production runs as a selective and conditional response to a sensor-based event whereby the first hybrid biochar production run is protected from a risk pertaining to the second hybrid biochar production run. Some variants implement synergies featuring biochar pyrolysis in close proximity to calcination or that otherwise facilitate durable “green cement.” Some variants implement a production line that can switch between a first operating protocol calibrated to yield more power and a second operating protocol calibrated to reduce a biochar-blend-type inventory shortage. And in some variants steam from one or more heaters powers a first turbine and a first condenser downstream is positioned adjacent an oxygen-depleted vessel so that some of the thermal energy recaptured during condensation is applied to produce biochar.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: Provided herein is a system for producing a product. The system generally comprises a large-area micro-stereolithography system, an optical imaging system, and a controller in communication with the large-area micro-stereolithography system and the optical imaging system. The large-area micro-stereolithography system is capable of generating the product by optically polymerizing successive layers of a curable resin at a build plane. The controller is capable of analyzing a focus level of the reference target based on the captured image; and based on the analyzing, adjusting a focus property of the projected image beam of the stereolithography system.

Abstract: A sanitation device includes a housing with a channel extending into the housing and a plurality of openings in the channel. A plurality of light emitting diodes emit light through the openings in the channel. A shield is coupled to the housing and a motion sensor emits and detect light through the shield when activated, such that the shield narrows a field of view of the motion sensor. The sanitation device is positioned near a common touch point with the motion sensor determining when an object is near, and has moved away from, the touch point. The plurality of light emitting diodes are activated to clean the touch point after the object moves away. The sanitation device may further include a status indicator light to provide information regarding the current state of operation of the sanitation device.

Abstract: Devices and techniques are generally described for unused identity and access management rights detection. In various examples, a first skill-usage vector associated with a first profile may be determined. A first nearest neighbor algorithm and the first skill-usage vector may be used to determine a second skill-usage vector grouped together with the first skill-usage vector in a feature space, where the second skill-usage vector is associated with a second profile. A first rights vector associated with the first profile may be determined. The first rights vector associated with the first profile may be compared to a second rights vector associated with the second profile. At least one unused right associated with the first profile may be determined based at least in part on the comparing of the first rights vector to the second rights vector.

Abstract: Apparatus and methods for gas distribution assemblies are provided. In one aspect, a gas distribution assembly is provided comprising an annular body comprising an annular ring having an inner annular wall, an outer wall, an upper surface, and a bottom surface, an upper recess formed into the upper surface, and a seat formed into the inner annular wall, an upper plate positioned in the upper recess, comprising a disk-shaped body having a plurality of first apertures formed therethrough, and a bottom plate positioned on the seat, comprising a disk-shaped body having a plurality of second apertures formed therethrough which align with the first apertures, and a plurality of third apertures formed between the second apertures and through the bottom plate, the bottom plate sealingly coupled to the upper plate to fluidly isolate the plurality of first and second apertures from the plurality of third apertures.

Abstract: Aspects of the present disclosure are directed to a collaborative workspace for an artificial reality (XR) environment. Some implementations can take advantage of the capabilities of XR systems when working on collaborative large documents, such as design sheets and spreadsheets. For example, when a user launches a link to a large design sheet in XR, the workspace can show both a large view of the entire collaborative design space, as well as a personal viewport into the area of the design space that the user is working on. The workspace can include a number of collaboration controls, such as being able to follow someone else's viewport, filtering of the large view to include only the area of the sheet where a user's team is working, replaying a user's edits or view while moving around the design sheet, etc.