Abstract: Disclosed herein are embodiments of an expandable replacement heart valve prosthesis. The expandable replacement heart valve prosthesis can include a number of different features, such as an hourglass (or generally hourglass) shape in the fully expanded position, anchor stiffening features, and improved retraction/retention configurations. For example, certain struts on the prosthesis can have different thicknesses/widths than other struts to improve compressibility.

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

Abstract: A system for monitoring medical conditions including pressure ulcers, pressure-induced ischemia and related medical conditions comprises at least one sensor adapted to detect one or more patient characteristic including at least position, orientation, temperature, acceleration, moisture, resistance, stress, heart rate, respiration rate, and blood oxygenation, a host for processing the data received from the sensors together with historical patient data to develop an assessment of patient condition and suggested course of treatment, including either suspending or adjusting turn schedule based on various types of patient movement. The sensor can include bi-axial or tri-axial accelerometers, as well as resistive, inductive, capacitive, magnetic and other sensing devices, depending on whether the sensor is located on the patient or the support surface, and for what purpose.

Abstract: A mitral valve prosthesis includes an hourglass shaped inner frame and a bulbous outer frame. A valve body having a plurality of leaflets is positioned within an interior region of the inner frame. The leaflets are shaped to substantially conform to an interior surface of the inner frame when the leaflets are in an open position. As a result, the gap between the leaflets and the inner frame is decreased, thereby reducing the likelihood of thrombus formation. Ventricular anchors are preferably provided along a distal end of the inner frame. The anchors extend proximally for placement behind native mitral valve leaflets. A fabric skirt may extend along an inner or outer surface of the outer frame. In preferred embodiments, the fabric skirt extends distally beyond a distal end of the outer frame and is adapted for forming a seal along the mitral valve annulus.

Abstract: Systems and methods to control data access and usage by storing a permitted use of a set of data items. The permitted use identifies: a set of computer resources to be used to operate on the set of data items; rules for operating on the data items; and a data product to be generated from the set of computer resources operating on the set of data items. A project space provides the set of computer resources to operate on the set of data items according to the permitted use, wherein the data product is to be transferred from the project space to a user device separate from the system; and a usage monitor records operations of the set of computer resources on the set of data items in the project space for compliance with the permitted use. A data air-lock mechanism implements dynamic permissions rules based on actual usages.

Abstract: A method of replacing the function of a native heart valve is achieved by inserting a distal end portion of a delivery apparatus into a patient's body, wherein a prosthetic valve is disposed along the distal end portion of the delivery apparatus. The prosthetic valve includes a collapsible and expandable annular body having a network of struts interconnected at a plurality of nodes to form a plurality of open cells. Atrial and ventricular flanges are coupled to the annular body and extend radially away from the annular body. The annular body includes three commissure support posts of fixed length that extend substantially the entire length of the annular body. A valve member is secured to the commissure support posts. The annular body is radially expanded within the native heart valve and the atrial and ventricular flanges are deployed on opposite sides of the native heart valve.

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: Systems and methods for detecting design redundancies and conflicts of a product or process are disclosed in the present application. A system for detecting redundancies and conflicts may parse a plurality of descriptions of functions to identify objects, verbs, and modifiers corresponding to descriptions of the plurality of descriptions. The system may determine lexical relationships between the identified objects, verbs, and modifiers based on lexical relationships. The system may determine dependencies of hierarchal relationships within the function model, and detect redundancies and conflicts based on the lexical relationships and the hierarchal relationships.

Abstract: Multiple, separately administrated computer systems storing slices of the cipher text of a Personally Identifiable Information (PII) data item that is represented by a token. The token is used as a substitute of the data item. The data item is encrypted using a public key. To recover the data item, a complete set of the slices is retrieved from the separate computer systems and decrypted using the private key corresponding to the public key. Instances and circumstances of the usages of the data item can be recorded under the token in a blockchain ledger in connection with the retrieval and/or decryption of the cipher text. A data item owner may use the data item and the public key to recreate the cipher text, retrieve the token stored with the cipher text in the separate computer systems, and then query the ledger for a usage history of the data item.

Abstract: Provided herein is a novel process for the preparation of an amino-pyrimidine and salts thereof. Also provided herein are novel intermediates used in this process and their preparation.

Abstract: Systems and methods to control data access and usage by storing a permitted use of a set of data items. The permitted use identifies: a set of computer resources to be used to operate on the set of data items; rules for operating on the data items; and a data product to be generated from the set of computer resources operating on the set of data items. A project space provides the set of computer resources to operate on the set of data items according to the permitted use, wherein the data product is to be transferred from the project space to a user device separate from the system; and a usage monitor records operations of the set of computer resources on the set of data items in the project space for compliance with the permitted use. A data air-lock mechanism implements dynamic permissions rules based on actual usages.

Abstract: A method for heart valve replacement comprises forming an incision in a wall of a ventricle of a heart and inserting a delivery apparatus and a prosthetic heart valve through the incision and into the ventricle of the heart. The prosthetic valve comprises a self-expanding frame having an annular main body and a valve member disposed within the annular main body. The prosthetic valve further comprises an atrial sealing member formed by an annular metal ring and a fabric, wherein only the fabric of the atrial sealing member is connected to the main body for enhancing the flexibility and conformability of the atrial sealing member. The method further comprises deploying the prosthetic valve from the delivery apparatus such that the atrial sealing member extends radially outwardly from the main body within an atrium of the heart and the main body self-expands to a deployed state within a native heart valve.

Abstract: Multiple, separately administrated computer systems storing slices of the cipher text of a Personally Identifiable Information (PII) data item that is represented by a token. The token is used as a substitute of the data item. The data item is encrypted using a public key. To recover the data item, a complete set of the slices is retrieved from the separate computer systems and decrypted using the private key corresponding to the public key. Instances and circumstances of the usages of the data item can be recorded under the token in a blockchain ledger in connection with the retrieval and/or decryption of the cipher text. A data item owner may use the data item and the public key to recreate the cipher text, retrieve the token stored with the cipher text in the separate computer systems, and then query the ledger for a usage history of the data item.

Abstract: A method of replacing the function of a native mitral valve is achieved by inserting a distal end portion of a delivery apparatus into a patient's body, wherein a prosthetic mitral valve is disposed along the distal end portion of the delivery apparatus. The prosthetic mitral valve includes a collapsible and expandable annular body having a network of struts interconnected at a plurality of nodes to form a plurality of open cells. Atrial and ventricular flanges are coupled to the annular body and extend radially away from the annular body. Three commissure support posts extend from the ventricular flange toward a ventricular end of the prosthetic valve and a valve member is secured to the commissure support posts. The prosthetic mitral valve is positioned within the native mitral valve of the patient's heart and the native mitral valve is pinched between the atrial and ventricular flanges.

Abstract: Dosing unit for dosing liquids, having a fluid unit for selectively providing an overpressure and a negative pressure on a working gas, which is accommodated in a fluid channel which is connected at a first end region to the fluid unit and which includes a second end region, having a first valve unit and having a second valve unit, which are arranged spaced apart from one another along the fluid channel and are each designed for selectively blocking or releasing the fluid channel in order to form in the fluid channel a fluid reservoir which is delimited by the two valve units and is provided for storing working gas, having a control unit for controlling the valve units, the fluid reservoir being assigned a pressure sensor which is designed to provide a pressure signal as a function of a working gas pressure and is electrically connected to the control unit.

Abstract: An implantable prosthetic valve includes a radially collapsible and radially expandable annular frame. The frame includes an annular main body sized to be implanted within a native mitral valve annulus. The frame also includes an atrial sealing member coupled to and extending radially away from the main body. The atrial sealing member is sized to extend over tissue of the native mitral annulus within a left atrium to reduce paravalvular leakage. The atrial sealing member includes an inner zig-zag portion and an outer zig-zag portion. The inner zig-zag portion and the outer zig-zag portion are connected to the main body portion only via a fabric to enhance flexibility of the atrial sealing member relative to the main body. The prosthetic valve also includes a valve member disposed within an interior of the frame.

Abstract: An implantable prosthetic valve includes a radially collapsible and radially expandable annular frame. The frame includes an annular main body sized to be implanted within a native mitral valve annulus. The frame also includes an atrial sealing member coupled to and extending radially away from the main body. The atrial sealing member is sized to extend over tissue of the native mitral annulus within a left atrium to reduce paravalvular leakage. The atrial sealing member includes an inner zig-zag portion and an outer zig-zag portion. The inner zig-zag portion and the outer zig-zag portion are connected to the main body portion only via a fabric to enhance flexibility of the atrial sealing member relative to the main body. The prosthetic valve also includes a valve member disposed within an interior of the frame.

Abstract: Embodiments of a prosthetic heart valve comprise an annular main body, an atrial cap extending radially outwardly from the atrial end of the main body, and a plurality of ventricular anchors extending outwardly from the ventricular end of the main body. Each ventricular anchor can have a proximal end portion connected to the ventricular end, an intermediate portion extending away from the atrial end and then back toward the atrial so as to define a first bend, and a free distal end portion that extends from the intermediate portion. The distal end portion can comprise a first section, a second section, and a second bend between the first and second sections, the first section extending from the intermediate portion in a direction toward the atrial end and radially away from the main body.

Abstract: A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

Abstract: An actuator assembly for an adjustable fluid-filled lens is provided. In some embodiments, the actuator assembly includes a clamp configured to adjust the optical power of the fluid lens module when the clamp is compressed. In some embodiments, a magnetic element is configured to adjust the optical power of the fluid-filled lens. In some embodiments, a plunger changes the optical power of the fluid lens module. In some embodiments, a reservoir is configured such that deformation of the reservoir changes the optical power of the fluid-filled lens. In some embodiments, a balloon is configured to deform the reservoir. In some embodiments, an adjustable fluid-filled lens includes a septum configured to be pierceable by a needle and automatically and fluidly seal a fluid chamber after withdrawal of the needle. In some embodiments, a thermal element can heat fluid within a fluid chamber to change an optical power of the lens module.