Abstract: Improved nucleic acid nanostructures provide a platform for stable and effective intra-cellular delivery of nucleic acids, suitably coding nucleic acids such as mRNA or ssDNA. A nucleic acid nanostructure is provided that comprises a first single stranded nucleic acid sequence that defines a scaffold sequence, wherein the scaffold sequence comprises at least one open reading frame that encodes a first gene product; and a plurality of single stranded nucleic acid sequences that define a plurality of staple sequences, wherein the plurality of staple sequences are capable of hybridising with one or more regions of the scaffold sequence in order to induce the formation of a geometrically defined higher order structure. The nanostructure may further comprise at least one membrane binding moiety, wherein the membrane binding moiety is configured to associate with a cell membrane.

Abstract: A cervical dilator is positioned in the cervix of a subject, as an outpatient procedure. Then, the cervical dilator is inflated by adding water to begin expansion of an expandable material located within the patient’s cervix. The expandable material expands the cervical dilator balloon at a rate of 1-3 mm/hr until a cervical dilation to 3 cm is obtained, typically at the subject’s home overnight prior to starting induction of labor or other procedures where cervical dilation in needed.

Abstract: A server has a processor and a memory connected to the processor. The memory stores instructions executed by the processor to receive broadcast reports from a network, where each broadcast report includes an account identifier, a group identifier, a data stream identifier and a value. Each broadcast report is stored in a database as raw data. A request for information in the database is received. In response to the request, the raw data is altered in accordance with a pre-defined data transformation to produce transformed data. A first visualization of the transformed data associated with a first data stream identifier of a first group identifier is rendered. A second visualization of the transformed data associated with a second data stream identifier of the first group identifier is rendered. The first visualization is supplied in conjunction with the second visualization in response to the request.

Abstract: Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.

Abstract: A liquid cooled coldplate has a tub with an inlet port and an outlet port and a plurality of pockets recessed within a top surface of the tub. Each pocket has a peripheral opening and a ledge, the ledge disposed inwardly and downwardly from the peripheral opening. The inlet port and outlet port are in fluid communication with the pocket via an inlet slot and an outlet slot. A plurality of cooling plates are each received by a pocket and recessed within the pocket. Each cooling plate comprises an electronics side for receiving electronics and enhanced side for cooling the cooling plate. The enhanced side of the cooling plate comprises a plurality of pins formed by micro deformation technology. The tub may be formed by extrusion.

Abstract: Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.

Abstract: Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.

Abstract: A liquid cooled coldplate has a tub with an inlet port and an outlet port and a plurality of pockets recessed within a top surface of the tub. Each pocket has a peripheral opening and a ledge, the ledge disposed inwardly and downwardly from the peripheral opening. The inlet port and outlet port are in fluid communication with the pocket via an inlet slot and an outlet slot. A plurality of cooling plates are each received by a pocket and recessed within the pocket. Each cooling plate comprises an electronics side for receiving electronics and enhanced side for cooling the cooling plate. The enhanced side of the cooling plate comprises a plurality of pins formed by micro deformation technology. The tub may be formed by extrusion.

Abstract: A liquid cooled coldplate has a tub with an inlet port and an outlet port and a plurality of pockets recessed within a top surface of the tub. Each pocket has a peripheral opening and a ledge, the ledge disposed inwardly and downwardly from the peripheral opening. The inlet port and outlet port are in fluid communication with the pocket via an inlet slot and an outlet slot. A plurality of cooling plates are each received by a pocket and recessed within the pocket. Each cooling plate comprises an electronics side for receiving electronics and enhanced side for cooling the cooling plate. The enhanced side of the cooling plate comprises a plurality of pins formed by micro deformation technology. The tub may be formed by extrusion.

Abstract: A liquid cooled coldplate has a tub with an inlet port and an outlet port and a plurality of pockets recessed within a top surface of the tub. Each pocket has a peripheral opening and a ledge, the ledge disposed inwardly and downwardly from the peripheral opening. The inlet port and outlet port are in fluid communication with the pocket via an inlet slot and an outlet slot. A plurality of cooling plates are each received by a pocket and recessed within the pocket. Each cooling plate comprises an electronics side for receiving electronics and enhanced side for cooling the cooling plate. The enhanced side of the cooling plate comprises a plurality of pins formed by micro deformation technology. The tub may be formed by extrusion.

Abstract: Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.

Abstract: A method implemented by a computer includes receiving a log file with log file data characterizing the operation of a system. A normalized format for the log file data is proposed. User input on the normalized format is solicited. The normalized format is set. The log file data is converted to the normalized format. A visualization application operative with the normalized format is selected. The visualization application supplies visualizations of the log file data.

Abstract: A computer implemented method includes receiving a data stream from a client device. The data stream includes a textual description of the operation of a system. The textual description includes at least one textual instruction. The textual description is converted to event waveforms where each event waveform has a time axis and event indicia. The textual instruction is rendered as an ideogram associated with the event waveforms. A representation of the event waveforms and the ideogram is supplied.

Abstract: A cold plate is manufactured by obtaining a base plate with a top surface, a bottom surface, and an edge. An inlet trough and an outlet trough are machined in the top surface. Fins are cut into the base plate with a tool that contacts the base plate in either the inlet trough and the outlet trough and then exits the base plate in the other of the inlet trough and the outlet trough. An inlet nozzle indent is machined from the inlet trough to the edge of the base plate, and an outlet nozzle indent is machined from the outlet trough to the edge of the base plate. A cover covers the inlet and outlet nozzle indents, and an inlet nozzle and outlet nozzle are secured to the inlet and outlet nozzle indents.

Abstract: A cold plate has a base plate connected to a cover to form an enclosure, with an inlet and outlet nozzle penetrating the enclosure for coolant flow. The base plate includes a top surface opposite a bottom surface, Where the top surface includes enhancements positioned within the enclosure under the cover. The base plate has an inlet trough and an outlet trough that serve as headers, so the inlet nozzle connects to the inlet trough, and coolant from the inlet trough can flow through the enhanced surface, collect in the outlet trough, and then exit the cold plate through the outlet nozzle. The enhanced surface includes enhancements that begin at a point in between the bottom surface and the top surface, and the enhancements extend to a point above the top surface. In another embodiment, electronic components can be soldered on a cold plate. The electronic component can be positioned in contact with the cold plate, and solid solder can be positioned at a contact point on the electronic component.

Abstract: This invention relates to a non-coding RNA (ncRNA) sequence from Human cytomegalovirus (HCMV) (termed “TRL4”) that specifically protects neuronal cells from cell death and may therefore be useful in the treatment of neurodegenerative disorders, such as Parkinson's disease.

Abstract: The apparatus in one example may have: aggregation groups of network ports; a respective aggregation group having a formation that is one of statically formed, dynamically formed, unknown, or empty; a respective aggregation group having a state that is one of a working state, a degraded state or a failed state; and graphical representation of the formations and states of the aggregation groups, the graphical representation depicting a current status of the aggregation groups of network ports.

Abstract: An implementation of an apparatus in one example may have: a network component, coupled with a communication network, having a plurality of network ports and a plurality of visual indicators that correspond respectively to the plurality of network ports; and a message received over the communication network by the network component, wherein the network component triggers a respective visual indicator, of the plurality of visual indicators, that corresponds to a selected port, of the plurality of network ports, based on the message received over the communication network.