Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: A grinder is provided that grinds materials such as tobacco, herb, spices, or food into smaller pieces for subsequent use. In some embodiments, relative motion between two components grinds the material into smaller pieces. In some embodiments, a cord is used to induce rotational motion between components. In various embodiments, a gear system having a driver is used to induce rotational motion where the driver is moved against a surface to drive the gear system. In some embodiments, a user moves a collar, a handle, or other component to induce rotational motion or longitudinal motion to grind the material.

Abstract: A high voltage power management module for supplying power to one or more motors for driving a fuel cell electric vehicle. The high voltage power management module comprises an E-Machine interface subsystem for exchanging DC power with an inverter configured to provide AC power to one or more motors for driving a drivetrain of the vehicle. The high voltage power management module further comprises a storage interface subsystem to exchange DC power with an electrical energy store for providing transient power to drive the fuel cell electric vehicle. The high voltage power management module further comprises a fuel cell interface subsystem for receiving DC power from a fuel cell stack of the vehicle configured to directly drive the one or more motors through the E-Machine interface subsystem of the high voltage power management module.

Abstract: A suturing instrument is provided. The suturing instrument comprises: a flexible shaft comprising an articulatable bending section; and a needle end effector located at a distal end of the bending section. The needle end effector comprises a toggle-based rotation mechanism to switch an orientation of a needle to engage and disengage the needle with a ferrule.

Abstract: A system for determining an ambient concentration of compositions for bathroom cleaning comprises a processor operable to receive a concentration measurement from a sensor over a network within a first period of time. The processor is operable to compare the received concentration measurement to a first threshold and to a second threshold greater than the first threshold. The processor is operable to instruct a memory communicatively coupled to the processor to store an indication that a bathroom was cleaned in response to a determination that the received concentration measurement is greater than the first threshold and less than the second threshold. The processor is operable to send an alert for display on a user device indicating either that the sensor has been tampered or that a spill event has occurred in response to a determination that the received concentration measurement is greater than the second threshold.

Abstract: A matching computer system for electronically generating, matching, and providing online user profiles, and determining a trust score for a user based upon at least social media data and insurance data is provided. The matching computer system may be configured to register users within the matching computer system, receive consent from the users to capture the social media data, and collect the social media data and the insurance data from each registered user. The matching computer system may also be configured to retrieve the social media data and the insurance data associated with each registered user. The matching computer system may be further configured to determine a trust score for each registered user based upon each respective social media data and each respective insurance data. Each trust score represents a level of trustworthiness of the user.

Abstract: In some examples, a system maintains, for a base storage structure and a collection of snapshots associated with the base storage structure, statistics relating to usage of storage space based on data of the base storage structure and the collection of snapshots. The system checks metadata of a first snapshot to determine validity of references in the metadata and a presence of any child of the first snapshot or a grandparent of the first snapshot. The system associates, based on the validity of the references in the metadata and the presence of any child or grandparent of the first snapshot, a hint with a metadata entry of a parent of the first snapshot to indicate that a metadata entry of the child or the grandparent is to be checked. The system updates, using the hint, the statistics relating to usage of storage space.

Abstract: A surgical system includes a drive unit on a support. The drive unit includes motors or other actuators and a plurality of output elements arranged such that operation of each drive unit linearly translates a corresponding one of the output elements. A surgical device has actuation elements extending through an elongate shaft to a distal articulation section, and an input subsystem carried at the proximal end of the shaft. Linear translatable input elements or pistons of the input subsystem are each associated with a corresponding one of the actuation elements. The input and output elements are positioned such that operation of an actuator linearly translates an output element, causing linear translation of a corresponding input element and engagement of an actuation element. A sterile drape is positionable between the input elements and the output elements.

Abstract: A system and method of order fulfilment is described. The system comprises a storage and retrieval system, a transfer system and at least one pick station. The transfer system further comprises conveyance means disposed between the storage and retrieval system and the pick station such that items delivered to the transfer system from the storage and retrieval system may be conveyed to the pick stations independently of the normal operation of the pick station.

Abstract: A method for controlling a dual fuel engine system includes estimating a total indicated engine load, where the total indicated engine load is based on a sum of a measured engine power and a power loss estimate. The method further includes determining a total fueling amount based on an engine speed and the total indicated engine load, where the total fueling amount includes a gas fueling amount and a diesel fueling amount. The method also includes controlling the dual fuel engine system using the total fueling amount.

Abstract: An item return for an item is identified and a workflow is determined based on first factors defined in customized rules. Resources associated with the workflow may be staged on devices associated with the item return and the workflow is initiated. When the item is detected as being present at a drop-off location for the item, item and customer information are gathered in accordance with the customized rules associated with the workflow. Security checks are processed using second factors defined in the customized rules. A decision is made based on the security checks as to whether the item return can continue processing with the workflow or as to whether an item return exception is to be raised for evaluation and/or inspection of the item and item return information collected before the item return exception was raised.

Abstract: The use of a compound as a corrosion inhibitor for metallic equipment, where the compound includes (i) a salt of an optionally substituted polycarboxylic acid or an anhydride thereof; and/or (ii) the reaction product of reactants comprising an optionally substituted polycarboxylic acid or an anhydride thereof and an alcohol and/or an amine, or a salt of the reaction product.

Abstract: A processor that includes a memory tagging extension (MTE) provides default tag bits employed when external devices, which are not compliant with MTE, access the memory circuit (e.g., employing direct memory access (DMA)). The default tag bits are stored as first tag bits with the data in memory. The processing circuit can include a mode indicator indicating whether default tag bits are employed. In a first mode, in which the default tag bits are not employed, an exception signal may be immediately generated in response to a mismatch between the first tag bits and second tag bits in the memory instruction. In a second mode, in response to a mismatch, the first tag bits are 10 further compared to the default tag bits and an error may be generated in response to a mismatch between the first tag bits and the default tag bits.

Abstract: A method includes receiving, from a subscriber device, a request including virtual region characteristics and an occupancy threshold, and determining, using image data captured by a camera and the virtual region characteristics, a virtual region corresponding to a portion of a physical region within a field of view of the camera. The virtual region is smaller than the physical region. The method also includes determining, using the image data, an occupancy of the virtual region and determining that the occupancy of the virtual region satisfies the occupancy threshold. In response to determining that the occupancy of the virtual region satisfies the occupancy threshold, the method also includes generating a notification to the subscriber device.

Abstract: The present disclosure provides rolling release launching system that is operative to receive and retain a drone or other payload in a protected launcher. The launcher helps to reduce the drag of the payload and to protect the payload from environmental factors. The payload is launched when a rotating door opens to expose the payload in a bay area. The rotating door may be parallel or concentric to a longitudinal axis of the body portion of the device. The payload may be launched using a biasing and fastening mechanism, which may include detachably coupling bracket, to induce an angular moment and releasing force on the payload during launch.

Abstract: The invention relates to compounds of Formula I? wherein R, R1, R2, R3, p, q and q? are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID-19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS-CoV-2 with the compounds.

Abstract: Apparatuses, systems, and methods for prosthetic valves. The prosthetic valves disclosed herein may be utilized for improved deployment, sealing, and anchoring to an implantation site. An implantation site may comprise a native heart valve or another implantation site in examples. Examples of prosthetic valves may include a proximal tensioning body positioned at a proximal portion of the prosthetic valve and a distal tensioning body positioned at a distal portion of the prosthetic valve. A sealing skirt may have a proximal end portion coupled to the proximal tensioning body and a distal end portion coupled to the distal tensioning body. The sealing skirt may be tensioned by the proximal tensioning body and the distal tensioning body and deflectable to conform to a shape of the native valve.