Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.

Abstract: An electrical receptacle including an outlet and a testing circuit. The outlet is configured to connect to an external load. The outlet includes a phase line and a neutral line. The testing circuit is configured to output a signal to a phase line of the outlet, receive a response signal from a neutral line of the outlet, and determine when the external load is electrically connected to the outlet based on the response signal.

Abstract: Disclosed herein are methods, pharmaceutical compositions for modulating T cell proteins. Also disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response.

Abstract: In a method of facilitating flight operations, a payload is coupled to a spacecraft via a payload interface. The relative alignment of the payload and the spacecraft is dynamically adjusted (e.g., for thrust alignment) while the payload remains coupled to the spacecraft.

Abstract: A breathing assistance apparatus and method of controlling a breathing assistance apparatus is disclosed. Particularly, the breathing assistance apparatus is controlled such that it has a drying cycle to enable drying of the tubing that supplies gases to a user and prevent the harbouring of pathogens within the tube. The drying cycle is preferably operated automatically by internal controllers in the apparatus. However, it may be manually activated by pressing a button on the apparatus. The drying cycle is preferably activated at the end of a user's treatment session.

Abstract: A technique includes providing at least one service blueprint to orchestrate application programming interfaces to manage the lifecycle of at least one cloud service.

Abstract: Various example embodiments described herein relates, to an item manipulation system that can include a control system and an end effector. The end effector can include a tube defining a channel between a first end and a second end. The tube can include, a flexible suction cup that can be disposed within the channel of the tube. In some examples, the flexible suction cup can engage a surface of the item based on suction force generated through the flexible suction cup. The end effector also includes a linear actuator that can be mechanically coupled to the flexible suction cup. The end effector can be configured to: extend, the flexible suction cup towards the second end of the channel to position at least a portion of the flexible suction cup outside the tube and retract, the flexible suction cup within the channel to position the flexible suction cup within the tube.

Abstract: The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.

Abstract: A king pin coupler assembly of a fifth wheel coupling. A coupler plate has a king pin aperture therein. A king pin is positioned to extend axially through the king pin aperture of the coupler plate. The king pin has a first portion with a neck for engaging a fifth wheel of the fifth wheel coupling, the first portion extending to a first side of the coupler plate. The king pin has a second portion on a second side of the coupler plate and welded to the coupler plate. A shielding apparatus is secured to one or both of the king pin and the coupler plate. The shielding apparatus includes a cover sealed to the first side of the coupler plate. The cover extends over the first portion of the king pin to shield the first portion of the king pin during liquid immersion of the king pin coupler assembly.

Abstract: In one aspect, a method includes receiving first content at a content-presentation device and presenting the first content, the first content comprising a first audio-content component. The content-presentation device may receive second content comprising a second audio-content component. The content-presentation device may determine a switch time at which to switch from presenting the first content to presenting the second content. During a first time interval prior to the switch time and ending at the switch time, the volume of the first audio-content component may be decreased to zero. At the switch time, the content-presentation device may switch from presenting the first content to presenting the second content. During a second time interval beginning at the switch time and ending at a second time after the switch time, the volume of the second audio-content component may be increased from zero to a non-zero volume level.

Abstract: Disclosed herein are compositions and methods for detecting RNA binding sites and RNA interacting partners involving the use of a modified capture oligonucleotide having a dual toehold design.

Abstract: In one aspect, a method includes receiving, by a content-management system and from a content-presentation device, a request for supplemental content, such as a replacement advertisement. The content-management system may then determine a technical characteristic of the content-presentation device and select supplemental content based at least in part on at least the determined technical characteristic of the content-presentation device. The content-management system may then cause the selected supplemental content to be transmitted to the content-presentation device to facilitate the content-presentation device performing a content modification operation.

Abstract: In one aspect, a method includes receiving, by a content-management system and from a content-presentation device, a request for supplemental content, such as a replacement advertisement. The content-management system may then determine a technical characteristic of the content-presentation device and select supplemental content based at least in part on at least the determined technical characteristic of the content-presentation device. The content-management system may then cause the selected supplemental content to be transmitted to the content-presentation device to facilitate the content-presentation device performing a content modification operation.

Abstract: In one aspect, a method includes receiving first content at a content-presentation device and presenting the first content, the first content comprising a first audio-content component. The content-presentation device may receive second content comprising a second audio-content component. The content-presentation device may determine a switch time at which to switch from presenting the first content to presenting the second content. During a first time interval prior to the switch time and ending at the switch time, the volume of the first audio-content component may be decreased to zero. At the switch time, the content-presentation device may switch from presenting the first content to presenting the second content. During a second time interval beginning at the switch time and ending at a second time after the switch time, the volume of the second audio-content component may be increased from zero to a non-zero volume level.

Abstract: Described herein is an inkjet ink composition for printing conductive traces. The inkjet ink composition comprises: polymer-capped metal nanoparticles; a first hydroxy compound, which is a monohydroxyl-substituted hydrocarbon comprising 1 to 6 carbon atoms; a second hydroxy compound, which is selected from a polyol, a monohydric ether and mixtures thereof; and water; wherein the weight ratio of water to first hydroxyl compound is in the range of 1:0.5 to 1:1.5; and wherein the weight ratio of water to second hydroxy compound is in the range of 1:0.5 to 1:1.5. Also described herein are a method of producing the inkjet ink composition and a method of printing conductive traces.