Patents by Inventor Matthew Allen Schiffler

Matthew Allen Schiffler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1
    Publication number: 20180250282
    Abstract: The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salt thereof, where R, R1, and G are as described herein; methods of preparing the compounds; and use of the compounds to treat pain and/or inflammation associated with arthritis or osteoarthritis.
    Type: Application
    Filed: May 7, 2018
    Publication date: September 6, 2018
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Peter Rudolph Manninen, Katherine Marie Partridge, Matthew Allen Schiffler, Alan M. Warshawsky, Jeremy Schulenburg York
  • Dimethylbenzoic acid compounds
    Patent number: 10005721
    Abstract: The present invention provides a compound of the Formula I: wherein A is: and W, Y, X, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof, for use as an inhibitor of the EP4 receptor.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: June 26, 2018
    Assignee: Eli Lilly and Company
    Inventors: Maria Jesus Blanco-Pillado, Peter Rudolph Manninen, Matthew Allen Schiffler, Tatiana Natali Vetman, Alan M Warshawsky, Jeremy Schulenburg York
  • Methyl-piperidine compounds useful for inhibiting microsomal prostaglandin Esynthase-1
    Patent number: 9962375
    Abstract: The present invention provides compounds of Formula (1), or a pharmaceutically acceptable salt thereof, formula (1), where R, R1, and G are as described herein; methods of preparing the compounds; and use of the compounds to treat pain and/or inflammation associated with arthritis or osteoarthritis.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: May 8, 2018
    Assignee: Eli Lilly and Company
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Peter Rudolph Manninen, Katherine Marie Partridge, Matthew Allen Schiffler, Alan M. Warshawsky, Jeremy Schulenburg York
  • Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1
    Publication number: 20170326128
    Abstract: The present invention provides compounds of Formula (1), or a pharmaceutically acceptable salt thereof, formula (1), where R, R1, and G are as described herein; methods of preparing the compounds; and use of the compounds to treat pain and/or inflammation associated with arthritis or osteoarthritis.
    Type: Application
    Filed: October 22, 2015
    Publication date: November 16, 2017
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Peter Rudolph Manninen, Katherine Marie Partridge, Matthew Allen Schiffler, Alan M. Warshawsky, Jeremy Schulenburg York
  • Phenoxyethyl cyclic amine derivatives and their activity as EP4 receptor modulators
    Patent number: 9776964
    Abstract: The present invention provides a compound of the Formula (I): wherein X, R, R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: October 3, 2017
    Assignee: Eli Lilly and Company
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Peter Rudolph Manninen, Matthew Allen Schiffler, Alan M Warshawsky, Jeremy Schulenburg York
  • Phenoxyethyl Cyclic Amine Derivatives and Their Activity as EP4 Receptor Modulators
    Publication number: 20160272585
    Abstract: The present invention provides a compound of the Formula (I): wherein X, R, R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 11, 2014
    Publication date: September 22, 2016
    Applicant: ELI LILLY AND COMPANY
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Peter Rudolph Manninen, Matthew Allen Schiffler, Alan M Warshawsky, Jeremy Schulenburg York
  • DIMETHYLBENZOIC ACID COMPOUNDS
    Publication number: 20160251306
    Abstract: The present invention provides a compound of the Formula I: wherein A is: and W, Y, X, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof, for use as an inhibitor of the EP4 receptor.
    Type: Application
    Filed: December 11, 2014
    Publication date: September 1, 2016
    Inventors: Maria Jesus Blanco-Pillado, Peter Rudolph Manninen, Matthew Allen Schiffler, Tatiana Natali Vetman, Alan M Warshawsky, Jeremy Schulenburg York
  • Phenoxyethyl piperidine compounds
    Patent number: 9402838
    Abstract: The present invention provides a compound of the Formula II: wherein X is: R1 is H, —CN, or F; R2 is H or methyl; R3 is H; and R4 is H, methyl, or ethyl; or R3 and R4 joined together form a cyclopropyl ring; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: August 2, 2016
    Assignee: Eli Lilly and Company
    Inventors: Matthew Allen Schiffler, Jeremy Schulenburg York
  • PHENOXYETHYL PIPERIDINE COMPOUNDS
    Publication number: 20150126555
    Abstract: The present invention provides a compound of the Formula II: wherein X is: R1 is H, —CN, or F; R2 is H or methyl; R3 is H; and R4 is H, methyl, or ethyl; or R3 and R4 joined together form a cyclopropyl ring; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 13, 2015
    Publication date: May 7, 2015
    Inventors: Matthew Allen SCHIFFLER, Jeremy Schulenburg YORK
  • Phenoxyethyl piperidine compounds
    Patent number: 8962659
    Abstract: The present invention provides a compound of the Formula II: wherein X is: R1 is H, —CN, or F; R2 is H or methyl; R3 is H; and R4 is H, methyl, or ethyl; or R3 and R4 joined together form a cyclopropyl ring; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: February 24, 2015
    Assignee: Eli Lilly and Company
    Inventors: Matthew Allen Schiffler, Jeremy Schulenburg York
  • PHENOXYETHYL PIPERIDINE COMPOUNDS
    Publication number: 20140005226
    Abstract: The present invention provides a compound of the Formula II: wherein X is: R1 is H, —CN, or F; R2 is H or methyl; R3 is H; and R4 is H, methyl, or ethyl; or R3 and R4 joined together form a cyclopropyl ring; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 20, 2013
    Publication date: January 2, 2014
    Inventors: Matthew Allen SCHIFFLER, Jeremy Schulenburg YORK
  • Imidazole-2-benzamide compounds useful for the treatment of osteoarthritis
    Patent number: 8252831
    Abstract: The present invention provides compounds of the formula below or pharmaceutical salts thereof, wherein R1, R2 and R3 are as described herein; methods of treating osteoarthritis using the compounds; and a process for preparing the compounds.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: August 28, 2012
    Assignee: Eli Lilly and Company
    Inventors: Steven Lee Kuklish, Matthew Allen Schiffler, Jeremy Schulenburg York
  • Cathepsin S inhibitor compounds
    Patent number: 8227468
    Abstract: The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof. Also, the present invention provides a pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable diluent or carrier. The present invention further provides methods for treating abdominal aortic aneurysm, plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: July 24, 2012
    Assignee: Eli Lilly and Company
    Inventors: Gary G. Deng, Konstantinos Gavardinas, Prabhakar Kondaji Jadhav, Euibong Jemes Kim, Matthew Allen Schiffler
  • Novel Imidazole-2-Benzamide Compounds Useful for the Treatment of Osteoarthritis
    Publication number: 20120157506
    Abstract: The present invention provides compounds of the formula below or pharmaceutical salts thereof, wherein R1, R2 and R3 are as described herein; methods of treating osteoarthritis using the compounds; and a process for preparing the compounds.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Applicant: ELI LILLY AND COMPANY
    Inventors: Steven Lee Kuklish, Matthew Allen Schiffler, Jeremy Schulenburg York
  • Cathepsin S Inhibitor Compounds
    Publication number: 20120095020
    Abstract: The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof. Also, the present invention provides a pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable diluent or carrier. The present invention further provides methods for treating abdominal aortic aneurysm, plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.
    Type: Application
    Filed: October 14, 2011
    Publication date: April 19, 2012
    Applicant: Eli Lilly and Company
    Inventors: Gary G. DENG, Konstantinos GAVARDINAS, Prabhakar Kondaji JADHAV, Euibong Jemes KIM, Matthew Allen SCHIFFLER